Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Matthew F, Brown"'
Autor:
James Schiemer, Andrew Maxwell, Reto Horst, Shenping Liu, Daniel P. Uccello, Kris Borzilleri, Nisha Rajamohan, Matthew F. Brown, Matthew F. Calabrese
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Bridging covalent ligand discovery with chimeric degrader design has emerged as a mechanism to target proteins that lack enzymatic activity or are intractable. Here, the authors use biochemical and cellular tools to deconvolute the role of covalent m
Externí odkaz:
https://doaj.org/article/8332ec11fd3e488aa9daf64205146e29
Publikováno v:
Nature Reviews Drug Discovery. 22:410-427
Autor:
C. Norman Coleman, Mansoor M. Ahmed, Jayne M. Stommel, Matthew F. Brown, Emanuel F. Petricoin, Mariaelena Pierobon, Lance Liotta, Barbara H. Rath, Sanjeewani T. Palayoor, Veit Sandfort, Molykutty J. Aryankalayil, Adeola Y. Makinde, Iris Eke
Gene expression of mTOR/AKT related genes after single dose and multifractionated radiation. DU145 human prostate carcinoma cells were irradiated with 10 Gy single dose (SD) or 5 fractions of 2 Gy or 10 fractions of 1 Gy (2 Gy a day) as multifraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bab3e78585e86f30e666071c3d4121c
https://doi.org/10.1158/1535-7163.22505059.v1
https://doi.org/10.1158/1535-7163.22505059.v1
Autor:
C. Norman Coleman, Mansoor M. Ahmed, Jayne M. Stommel, Matthew F. Brown, Emanuel F. Petricoin, Mariaelena Pierobon, Lance Liotta, Barbara H. Rath, Sanjeewani T. Palayoor, Veit Sandfort, Molykutty J. Aryankalayil, Adeola Y. Makinde, Iris Eke
Radiation schedule for the cell culture and xenograft experiments. Human prostate cancer cells were either plated or injected subcutaneously into the flanks of the right hind legs of athymic nude mice. After 24 h (in vitro) or tumors reached a tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0066ad74fda971b50a77140ebccdba85
https://doi.org/10.1158/1535-7163.22505062
https://doi.org/10.1158/1535-7163.22505062
Autor:
C. Norman Coleman, Mansoor M. Ahmed, Jayne M. Stommel, Matthew F. Brown, Emanuel F. Petricoin, Mariaelena Pierobon, Lance Liotta, Barbara H. Rath, Sanjeewani T. Palayoor, Veit Sandfort, Molykutty J. Aryankalayil, Adeola Y. Makinde, Iris Eke
Densitometric analysis of basal protein expression and phosphorylation in DU145 and PC3 cells. Western blots of 3D-grown prostate cancer cell lines were evaluated with ImageJ. Phospho-protein expression was normalized to total protein expression. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f8f1290a69799a99acfb5addf34259
https://doi.org/10.1158/1535-7163.22505056
https://doi.org/10.1158/1535-7163.22505056
Autor:
C. Norman Coleman, Mansoor M. Ahmed, Jayne M. Stommel, Matthew F. Brown, Emanuel F. Petricoin, Mariaelena Pierobon, Lance Liotta, Barbara H. Rath, Sanjeewani T. Palayoor, Veit Sandfort, Molykutty J. Aryankalayil, Adeola Y. Makinde, Iris Eke
Subcellular localization of AKT and mTOR after radiation. Immunofluorescence staining of AKT and mTOR in irradiated and unirradiated DU145 and PC3 cells. Nuclear staining was performed with DAPI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cbbd5b4504d65aaab670ed986d81a8
https://doi.org/10.1158/1535-7163.22505053
https://doi.org/10.1158/1535-7163.22505053
Autor:
C. Norman Coleman, Mansoor M. Ahmed, Jayne M. Stommel, Matthew F. Brown, Emanuel F. Petricoin, Mariaelena Pierobon, Lance Liotta, Barbara H. Rath, Sanjeewani T. Palayoor, Veit Sandfort, Molykutty J. Aryankalayil, Adeola Y. Makinde, Iris Eke
Implementing targeted drug therapy in radio-oncologic treatment regimens has greatly improved the outcome of cancer patients. However, the efficacy of molecular targeted drugs such as inhibitory antibodies or small molecule inhibitors essentially dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7efe221a3c82180957e5bfee7093de10
https://doi.org/10.1158/1535-7163.c.6537934.v1
https://doi.org/10.1158/1535-7163.c.6537934.v1
Autor:
C. Norman Coleman, Mansoor M. Ahmed, Jayne M. Stommel, Matthew F. Brown, Emanuel F. Petricoin, Mariaelena Pierobon, Lance Liotta, Barbara H. Rath, Sanjeewani T. Palayoor, Veit Sandfort, Molykutty J. Aryankalayil, Adeola Y. Makinde, Iris Eke
Oligonucleotides used for CRISPR/Cas9 gene editing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4c74d3adc11aa7e9b213150d6eb5ba
https://doi.org/10.1158/1535-7163.22505047.v1
https://doi.org/10.1158/1535-7163.22505047.v1
Autor:
Chantelle S. Lloyd, Ruth A. Lanius, Matthew F. Brown, Richard J. Neufeld, Paul A. Frewen, Margaret C. McKinnon
Publikováno v:
Chronic Stress, Vol 3 (2019)
Background Peri-traumatic tonic immobility has been associated with the development and course of post-traumatic stress disorder. Despite serving as an adaptive late-stage defense response, tonic immobility that continues in response to post-traumati
Externí odkaz:
https://doaj.org/article/fd1a8525e1d548b283c06fcf37f73c87
Autor:
Anette Duensing, Stefan Duensing, Jonathan A. Fletcher, Shih-Fan Kuan, Brian P. Rubin, Anna Chin, Payel Chatterjee, Danushka Seneviratne, Matthew F. Brown, Thomas Mühlenberg, Joshua A. Parry, Sebastian Bauer
Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although >85% of GIST patients treated with the small-molecule inhibitor imatinib mesylate (Gleevec) achieve disease stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59762687bb37d43513648e687d49fe5c
https://doi.org/10.1158/0008-5472.c.6499614.v1
https://doi.org/10.1158/0008-5472.c.6499614.v1