Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew Esparza"'
Autor:
Prasanna Bhat, Vasilisa Aksenova, Matthew Gazzara, Emily A. Rex, Sadaf Aslam, Christina Haddad, Shengyan Gao, Matthew Esparza, Tolga Cagatay, Kimberly Batten, Sara S. El Zahed, Alexei Arnaoutov, Hualin Zhong, Jerry W. Shay, Blanton S. Tolbert, Mary Dasso, Kristen W. Lynch, Adolfo García-Sastre, Beatriz M. A. Fontoura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins localized at the nucleoplasmic side o
Externí odkaz:
https://doaj.org/article/ef526c85c77e4e78867cbdc75323343a
Autor:
Matthew Esparza, Amir Mor, Hanspeter Niederstrasser, Kris White, Alexander White, Ke Zhang, Shengyan Gao, Juan Wang, Jue Liang, Sei Sho, Ramanavelan Sakthivel, Adwait A Sathe, Chao Xing, Raquel Muñoz-Moreno, Jerry W Shay, Adolfo García-Sastre, Joseph Ready, Bruce Posner, Beatriz M A Fontoura
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008407 (2020)
Influenza A viruses are human pathogens with limited therapeutic options. Therefore, it is crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted of 8 RNA segments. Two
Externí odkaz:
https://doaj.org/article/773ab3005ec64c18aba2b674724f2b62
Autor:
Jerry W. Shay, Jue Liang, Prasanna Bhat, Joseph M. Ready, Beatriz M. A. Fontoura, Matthew Esparza, Bruce A. Posner, Jacinth Naidoo, Busola R. Alabi, Kris M. White, Adolfo García-Sastre, Briana L. McGovern, Michael A. P. Williams, Hanspeter Niederstrasser
Publikováno v:
J Med Chem
Influenza viruses cause approximately half a million deaths every year worldwide. Vaccines are available but partially effective, and the number of antiviral medications is limited. Thus, it is crucial to develop therapeutic strategies to counteract
Autor:
Shengyan Gao, Matthew Esparza, Ishmael Dehghan, Vasilisa Aksenova, Ke Zhang, Kimberly Batten, Max B. Ferretti, Bridget E. Begg, Tolga Cagatay, Jerry W. Shay, Adolfo García-Sastre, Elizabeth J. Goldsmith, Zhijian J. Chen, Mary Dasso, Kristen W. Lynch, Melanie H. Cobb, Beatriz M. A. Fontoura
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Nuclear speckles are non–membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing factors. More recently, nuclear speckles have also been implicated in splicing and export of a subset of mRNAs, including the
Autor:
Yihu Xie, Beatriz M. A. Fontoura, Ke Zhang, Juan Wang, Adolfo García-Sastre, Yi Ren, Raquel Muñoz-Moreno, Matthew Esparza, Liang Zhang
Publikováno v:
Nature microbiology
Influenza viruses antagonize key immune defence mechanisms via the virulence factor non-structural protein 1 (NS1). A key mechanism of virulence by NS1 is blocking nuclear export of host messenger RNAs, including those encoding immune factors1–3; h
Autor:
Anil Kumar, Christopher Ptak, Ke Zhang, Tadashi Makio, Beatriz M. A. Fontoura, Matthew Esparza, Tom C. Hobman, Hualin Zhong, Zhijian J. Chen, Thomas Kehrer, Yi Ren, Adolfo García-Sastre, Richard W. Wozniak, Yihu Xie, Shengyan Gao, Boning Gao, John D. Minna, Ishmael Dehghan, Lisa Miorin
Publikováno v:
Science Advances
SARS-CoV-2 Nsp1 protein binds the mRNA export receptor NXF1-NXT1 to inhibit nuclear export of mRNAs and promote infection.
The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted th
The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted th
Autor:
Hanspeter Niederstrasser, Chao Xing, Ramanavelan Sakthivel, Juan Wang, Alexander D. White, Joseph M. Ready, Sei Sho, Matthew Esparza, Amir Mor, Jerry W. Shay, Kris M. White, Adolfo García-Sastre, Adwait Amod Sathe, Jue Liang, Ke Zhang, Beatriz M. A. Fontoura, Bruce A. Posner, Shengyan Gao, Raquel Muñoz-Moreno
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008407 (2020)
PLoS Pathogens
PLoS Pathogens
Influenza A viruses are human pathogens with limited therapeutic options. Therefore, it is crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted of 8 RNA segments. Two
Autor:
Yi Ren, Kevin L. Schey, Beatriz M. A. Fontoura, Raquel Muñoz-Moreno, Liang Zhang, Juan Wang, Andrew K. Morris, Zhen Wang, Yihu Xie, Adolfo García-Sastre, Matthew Esparza, Ke Zhang
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Yang Xie, Tuyen T. Dang, Matthew Esparza, Yunyun Zhou, Amanda M. Prechtl, Han Sun, Gray W. Pearson, Jill M. Westcott, Erin A. Maine
Publikováno v:
Journal of Clinical Investigation. 125:1927-1943
Tumor cells can engage in a process called collective invasion, in which cohesive groups of cells invade through interstitial tissue. Here, we identified an epigenetically distinct subpopulation of breast tumor cells that have an enhanced capacity to
Autor:
Alexander D. White, Beatriz M. A. Fontoura, Kazunori Koide, Amir Mor, Matthew G. Thompson, Kristen W. Lynch, Ke Zhang, Matthew Esparza, Raquel Muñoz-Moreno, Adolfo García-Sastre
Publikováno v:
Nature Microbiology. 2
Nature Microbiology 1, 16069 (2016); published online 27 May 2016; corrected 9 January 2017 In the version of this Article originally published, an additional National Institute of Health grant (NIH R21 AI119304) should have been acknowledged for the