Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Matthew Edelstein"'
Autor:
Joe Media, Frederick A. Valeriote, Ben Chen, Halina Pietraszkiewicz, Jayshree Mishra, Peter R. Andreana, Matthew Edelstein, Jiajiu Shaw, Hao Jiang, Jean P. Bourgault, Narendra Kumar, Kevin R. Bobbitt
Publikováno v:
American Journal of Biomedical Sciences. :14-25
A new series of isoxazole derivatives, N-phenyl-5-carboxamidyl isoxazoles, was investigated for their anticancer activity with solid tumor selectivity. Six N-phenyl-5-carboxamidylisoxazoles were chemically synthesized and evaluated by the in vitro di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7c3baf6fdc4e2719aa31557f52a13f
https://doi.org/10.5099/aj120100014
https://doi.org/10.5099/aj120100014
Autor:
Juiwanna Kushner, Chiab Simpson, Matthew Edelstein, Thomas H. Corbett, Susan Pugh, Jennifer Paluch, Jerome P. Horwitz, Lisa Polin, Kathryn White, Stuart T. Hazeldine, Joseph A. Fontana, Patricia LoRusso
Publikováno v:
Investigational New Drugs. 20:13-22
XK-469 is advancing to Phase I clinical trials. Preclinical studies were carried out to assist in clinical applications. DOSE-SCHEDULE ROUTE TESTING: Single dose i.v. treatment with XK-469 produced lethality (LD20 to LD100) above 142 mg/kg. Optimum t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227beaf76a7dbbb85c03daba14068274
https://doi.org/10.1023/a:1014469828729
https://doi.org/10.1023/a:1014469828729
Autor:
Frederick A, Valeriote, Karen, Tenney, Joseph, Media, Halina, Pietraszkiewicz, Matthew, Edelstein, Tyler A, Johnson, Taro, Amagata, Phillip, Crews
Publikováno v:
Journal of experimental therapeuticsoncology. 10(2)
A collaborative program was initiated in 1990 between the natural product chemistry laboratory of Dr. Phillip Crews at the University of California Santa Cruz and the experimental therapeutics laboratory of Dr. Fred Valeriote at the Henry Ford Hospit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbd591b071a88d3ff37e2c8ccc7078d0
https://pubmed.ncbi.nlm.nih.gov/23350352
https://pubmed.ncbi.nlm.nih.gov/23350352
Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity
Autor:
Subhash C. Sinha, Halina Pietraszkiewicz, Matthew Edelstein, Frederick Valeriote, Zheng Zheng Huang, Zhiyong Chen, Eiko Nakamaru-Ogiso
Publikováno v:
Journal of medicinal chemistry. 51(22)
A systematic analysis using ten synthetic asimicin stereoisomers revealed that the stereochemistry of the bis-tetrahydrofuran core, including the tetrahydrofuran rings and the adjacent hydroxy functions, had significant effect on its cytotoxicity. Ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c24a3d2e4556eb34afb4b91af956ca3
https://pubmed.ncbi.nlm.nih.gov/18975929
https://pubmed.ncbi.nlm.nih.gov/18975929
Autor:
Matthew Edelstein, Joseph Media, Karen Tenney, Robert H. Cichewicz, Taro Amagata, Susan L. Mooberry, Phillip Crews, Frederick A. Valeriote, Tyler A. Johnson
Publikováno v:
Journal of medicinal chemistry. 51(22)
This study involved a campaign to isolate and study additional latrunculin analogues from two taxonomically unrelated sponges, Cacospongia mycofijiensis and Negombata magnifica. A total of 13 latrunculin analogues were obtained by four different ways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732fe17948d90c7ebaa749982f456764
https://pubmed.ncbi.nlm.nih.gov/18942825
https://pubmed.ncbi.nlm.nih.gov/18942825
Autor:
Stuart T. Hazeldine, Juiwanna Kushner, Jerome P. Horwitz, Kathryn White, Eduardo Palomino, Lisa Polin, Jennifer Paluch, Matthew Edelstein, Thomas H. Corbett
Publikováno v:
Journal of medicinal chemistry. 44(11)
2-(4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cd019780552d04f17d1715fd6fd0c7
https://pubmed.ncbi.nlm.nih.gov/11356111
https://pubmed.ncbi.nlm.nih.gov/11356111
Autor:
Lisa Polin, Jennifer A. Meyer, Jerome P. Horwitz, Juiwanna Kushner, Robert Perni, Charles Grieshaber, Nancy Lowichik, Matthew Edelstein, Thomas H. Corbett, Richard Philion, Steven A. Elenbaas, Lance K. Heilbrun, Patricia LoRusso, Susan Coughlin, Salina Chinnukroh, Mark P. Wentland, James B. Rake, Kathryn White, Susan Pugh, Chiab Panchapor, Jennifer Czarnecki
Publikováno v:
Investigational new drugs. 17(1)
A highly active and broadly active thioxanthone has been identified: N-[[1-[[2-(Diethylamino)ethyl]amino]-7-methoxy-9-oxo-9H-thioxanthen++ +-4-yl] methylformamide (SR271425, BCN326862, WIN71425). In preclinical testing against a variety of subcutaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d32a192724e592d498f14a195e5a777
https://pubmed.ncbi.nlm.nih.gov/10555119
https://pubmed.ncbi.nlm.nih.gov/10555119
Autor:
Taro Amagata, Tyler A. Johnson, Robert H. Cichewicz, Karen Tenney, Susan L. Mooberry, Joseph Media, Matthew Edelstein, Frederick A. Valeriote, Phillip Crews
Publikováno v:
Journal of Medicinal Chemistry; Nov2008, Vol. 51 Issue 22, p7234-7242, 9p