Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Matthew E. Price"'
Autor:
Matthew E. Price
Each year, hundreds of thousands of people apply for asylum in Europe, North America, and Australia. Some fear political persecution and genocide; some are escaping civil war or environmental catastrophe; others flee poverty, crime, or domestic viole
Autor:
Helen Rice, Sarah J. Fairhall, John E.H. Tattersall, Cerys J. Docx, Luke Whiley, Daniel P. Flint, Christopher M. Timperley, Sarah J.C. Poole, A. Christopher Green, Michael Bird, Matthew E. Price
Publikováno v:
Toxicology Letters. 244:154-160
Current organophosphorus nerve agent medical countermeasures do not directly address the nicotinic effects of poisoning. A series of antinicotinic bispyridinium compounds has been synthesized in our laboratory and screened in vitro. Their actions can
Autor:
T.R. Laws, Charlotte Whitmore, E.R. Emery, Matthew E. Price, John E.H. Tattersall, R.L. Perrott, R.R. McColm, A.C. Green, Helen Rice, T.M. Mann
Publikováno v:
Toxicology letters. 293
The prolonged systemic exposure that follows skin contamination with low volatility nerve agents, such as VX, requires treatment to be given over a long time due to the relatively short half-lives of the therapeutic compounds used. Bioscavengers, suc
The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig
Autor:
E.R. Emery, C. Whitmore, John E. H. Tattersall, S. Stubbs, D. Flint, Stuart J. Armstrong, H. Rice, Matthew E. Price, A.R. Cook, N. Roughley, T.M. Mann
Publikováno v:
Toxicology letters. 293
Post-exposure nerve agent treatment usually includes administration of an oxime, which acts to restore function of the enzyme acetylcholinesterase (AChE). For immediate treatment of military personnel, this is usually administered with an autoinjecto
Autor:
Stuart J. Armstrong, John E. H. Tattersall, Cerys J. Docx, Matthew E. Price, A. Christopher Green, Helen Mumford
Publikováno v:
Chemico-Biological Interactions. 203:160-166
Potent organophosphorous (OP) agents, such as VX, are hazardous by absorption through the skin and are resistant to conventional pharmacological antidotal treatments. The residence time of a stoichiometric bioscavenger, human butyrylcholinesterase (h
Autor:
Helen J. Groombridge, A. Christopher Green, Helen Rice, Christopher M. Timperley, Matthew E. Price, Stuart Graham, Christopher H. Dalton, John Jenner
Publikováno v:
Proceedings. Mathematical, Physical, and Engineering Sciences / The Royal Society
To support the effort to eliminate the Syrian Arab Republic chemical weapons stockpile safely, there was a requirement to provide scientific advice based on experimentally derived information on both toxicity and medical countermeasures (MedCM) in th
Autor:
Stuart J. Armstrong, John E. H. Tattersall, Tom M. Mann, A. Chris Green, Helen Rice, Matthew E. Price
Publikováno v:
Chemico-biological interactions. 259
The provision of effective Medical Countermeasures (MedCM) for all agents and routes of exposure is a strategic goal of defence research and development. In the case of military autoinjector-based therapies for nerve agent poisoning, current treatmen
Autor:
Christopher M. Timperley, Simon R. Turner, Mike Bird, Matthew E. Price, C. Green, John E. H. Tattersall, John E. Chad
Publikováno v:
Med. Chem. Commun.. 3:352-356
Syntheses of 1,1-(propane-1,3-diyl)bis(4-tert-butylpyridinium) diiodide (MB327) and its di(methanesulfonate) salt (MB399) are described. Protection experiments in guinea-pigs showed that MB399, a noncompetitive nicotinic antagonist that produces fast
Autor:
John E. H. Tattersall, Christopher M. Timperley, Simon R. Turner, Mike Bird, Matthew E. Price, John E. Chad, A.C. Green
Publikováno v:
Toxicology Letters. 206:105-111
The acute toxicity of organophosphorus (OP) nerve agents arises from accumulation of acetylcholine (ACh) and overstimulation of ACh receptors. The mainstay of current pharmacotherapy is the competitive muscarinic antagonist, atropine. Nicotinic antag
Publikováno v:
Toxicology. 233:120-127
Medical countermeasures provide a key role in the UK integrated approach to chemical defence and are aimed at preventing or mitigating the effects of exposure to nerve agents. It is UK policy that medical countermeasures will be licensed products. De