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of 35
pro vyhledávání: '"Matthew E, Griffin"'
Autor:
Matthew E. Griffin, Howard C. Hang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 31, Iss , Pp 100818- (2022)
The human microbiota acts as a diverse source of molecular cues that influence the development and homeostasis of the immune system. Beyond endogenous roles in the human holobiont, host-microbial interactions also alter outcomes for immune-related di
Externí odkaz:
https://doaj.org/article/c1cbaf1288544a6ba212cb29611a6788
Publikováno v:
Cell Chemical Biology. 30:436-456
The bacterial cell wall is composed of a highly crosslinked matrix of glycopeptide polymers known as peptidoglycan that dictates bacterial cell morphology and protects against environmental stresses. Regulation of peptidoglycan turnover is therefore
Autor:
Xiaohui Zhao, Kathryn R. Stein, Victor Chen, Matthew E. Griffin, Luke L. Lairson, Howard C. Hang
Publikováno v:
Nature Chemical Biology.
Publikováno v:
Cell. 185:2657-2677
Cellular carbohydrates or glycans are critical mediators of biological function. Their remarkably diverse structures and varied activities present exciting opportunities for understanding many areas of biology. In this primer, we discuss key methods
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 12, Pp n/a-n/a (2019)
Abstract The discovery of defined peptidoglycan metabolites that activate host immunity and their specific receptors has revealed fundamental insights into host–microbe recognition and afforded new opportunities for therapeutic development against
Externí odkaz:
https://doaj.org/article/2da86f47ee2d4a0885b24615df594db8
Autor:
Kyung Ku Jang, Thomas Heaney, Mariya London, Yi Ding, Frank Yeung, Defne Ercelen, Ying-Han Chen, Jordan Axelrad, Sakteesh Gurunathan, A. Marijke Keestra-Gounder, Matthew E. Griffin, Howard C. Hang, Ken Cadwell
Publikováno v:
bioRxiv
SUMMARYLoss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe4686792053bbd80204d00da5a160b
https://doi.org/10.1101/2023.01.29.526128
https://doi.org/10.1101/2023.01.29.526128
Publikováno v:
bioRxiv
The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies onEnterococcusspecies revealed peptidoglycan remodeling and activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274ddc25813ab287c7e70f435c8931da
https://europepmc.org/articles/PMC9901186/
https://europepmc.org/articles/PMC9901186/
Autor:
Wilfred F. J. van IJcken, Marc Sanson, Thais S. Sabedot, C Mircea S Tesileanu, Roberta Rudà, Thierry Gorlia, Olivier Chinot, Iris de Heer, Leland Rogers, Kenneth Aldape, Alba A. Brandes, Walter Taal, Kin Jip Cheung, Anna K. Nowak, Robert B. Jenkins, Michael A. Vogelbaum, Vassilis Golfinopoulos, Pim J. French, Wolfgang Wick, Myra van Linde, Hendrikus J. Dubbink, Johan M. Kros, M. Weller, Matthew E. Griffin, Rutger W W Brouwer, Brigitta G. Baumert, Sanjeev Gill, Houtan Noushmehr, Paul Clement, Catherine McBain, Helen Wheeler, Jean Francois Baurain, Pieter Wesseling, Sara Erridge, Youri Hoogstrate, Warren P. Mason, Andreas von Deimling, Martin J. van den Bent
Publikováno v:
Neuro-Oncology
Neuro-Oncology, Oxford University Press (OUP), 2021, 23 (9), pp.1547-1559. ⟨10.1093/neuonc/noab088⟩
Neuro-Oncology, 23(9), 1547-1559. Oxford University Press
Neuro-oncology, Vol. xx, no.xx, p. xx (2021)
Neuro-Oncology, 2021, 23 (9), pp.1547-1559. ⟨10.1093/neuonc/noab088⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neuro-oncology, 23(9), 1547-1559. Oxford University Press
Neuro-Oncology, Oxford University Press (OUP), 2021, 23 (9), pp.1547-1559. ⟨10.1093/neuonc/noab088⟩
Neuro-Oncology, 23(9), 1547-1559. Oxford University Press
Neuro-oncology, Vol. xx, no.xx, p. xx (2021)
Neuro-Oncology, 2021, 23 (9), pp.1547-1559. ⟨10.1093/neuonc/noab088⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neuro-oncology, 23(9), 1547-1559. Oxford University Press
Background Survival in patients with IDH1/2-mutant (mt) anaplastic astrocytomas is highly variable. We have used the prospective phase 3 CATNON trial to identify molecular factors related to outcome in IDH1/2mt anaplastic astrocytoma patients. Method
Chemoproteomics of microbiota metabolites reveals small-molecule agonists for orphan receptor GPRC5A
The microbiota generates diverse metabolites that can engage multiple pathways to modulate host physiology and disease, but their protein targets and mechanism(s) of action have not been fully elucidated. To address this challenge, we focused on indo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::062f150e1d97e8e4584258ecf920a03e
https://doi.org/10.1101/2021.12.16.472979
https://doi.org/10.1101/2021.12.16.472979
Autor:
Matthew E. Griffin, Howard C. Hang
Publikováno v:
Cancer cell. 39(12)
Reprogramming the tumor microenvironment may be a key strategy to broaden the efficacy of current cancer immunotherapies. In a recent Nature paper, Canale et al. use synthetic biology to alter intratumoral arginine levels via engineered bacteria, lea