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Autor:
Matthew Dale Reeves, Dwight D. Weller, Brett L. Mellbye, Bruce L. Geller, Patrick L. Iversen, Candace E. Lovejoy, Jed N. Hassinger
Publikováno v:
Journal of Antimicrobial Chemotherapy. 65:98-106
Objectives Phosphorodiamidate morpholino oligomers (PMOs) are uncharged DNA analogues that can inhibit bacterial growth by a gene-specific, antisense mechanism. Attaching cationic peptides to PMOs enables efficient penetration through the Gram-negati