Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Matthew D. Zimmerman"'
Autor:
Nadine Alvarez, Gregory C. Adam, John A. Howe, Vijeta Sharma, Matthew D. Zimmerman, Enriko Dolgov, Risha Rasheed, Fatima Nizar, Khushboo Sahay, Andrew M. Nelson, Steven Park, Xiaoyan Zhou, Christine Burlein, John F. Fay, Daniel V. Iwamoto, Carolyn M. Bahnck-Teets, Krista L. Getty, Shih Lin Goh, Imad Salhab, Keith Smith, Christopher W. Boyce, Tamara D. Cabalu, Nicholas Murgolo, Nicholas G. Fox, Todd W. Mayhood, Valerie W. Shurtleff, Mark E. Layton, Craig A. Parish, John A. McCauley, David B. Olsen, David S. Perlin
Publikováno v:
Viruses, Vol 16, Iss 7, p 1158 (2024)
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to be a global threat due to its ability to evolve and generate new subvariants, leading to new waves of infection. Additionally, other coronaviruses like Middle East respira
Externí odkaz:
https://doaj.org/article/5a441246ad714e97bc953aaa660b6bd5
Autor:
Kaj M. Kreutzfeldt, Robert S. Jansen, Travis E. Hartman, Alexandre Gouzy, Ruojun Wang, Inna V. Krieger, Matthew D. Zimmerman, Martin Gengenbacher, Jansy P. Sarathy, Min Xie, Véronique Dartois, James C. Sacchettini, Kyu Y. Rhee, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Drug tolerance complicates the treatment of tuberculosis. Here, Kreutzfeldt et al. show that the protein CinA mediates drug tolerance in Mycobacterium tuberculosis by cleaving NAD-drug adducts, suggesting CinA as a potential target to shorten tubercu
Externí odkaz:
https://doaj.org/article/0ffbbce15de04ec482009cd19552b697
Autor:
Lea Mann, Uday S. Ganapathy, Rana Abdelaziz, Markus Lang, Matthew D. Zimmerman, Véronique Dartois, Thomas Dick, Adrian Richter
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT In a library screen of tuberculosis-active compounds for anti-Mycobacterium abscessus activity, we previously identified the synthetic phenylalanine amide MMV688845. In Mycobacterium tuberculosis, this class was shown to target the RpoB subu
Externí odkaz:
https://doaj.org/article/2af1a16dafac446d841e637afa1f0422
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques
Autor:
Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Mohd Saqib, Samantha J. Nelson, Pauline Maiello, Chelsea M. Causgrove, Cassaundra L. Ameel, Brianne Stein, H. Jacob Borish, Alexander G. White, Edwin C. Klein, Matthew D. Zimmerman, Véronique Dartois, Philana Ling Lin, Christopher M. Sassetti, JoAnne L. Flynn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is
Externí odkaz:
https://doaj.org/article/cb9c7db12abd401b9c0a88eb06a4e51b
Autor:
Helen M. Berman, Margaret J. Gabanyi, Colin R. Groom, John E. Johnson, Garib N. Murshudov, Robert A. Nicholls, Vijay Reddy, Torsten Schwede, Matthew D. Zimmerman, John Westbrook, Wladek Minor
Publikováno v:
IUCrJ, Vol 2, Iss 1, Pp 45-58 (2015)
Structural and functional studies require the development of sophisticated `Big Data' technologies and software to increase the knowledge derived and ensure reproducibility of the data. This paper presents summaries of the Structural Biology Knowledg
Externí odkaz:
https://doaj.org/article/6928591e4171455bb695cea1e60e9f52
Autor:
Satish R. Malwal, Ben Mazurek, Jihee Ko, Pujun Xie, Chikako Barnes, Christine Varvitsiotis, Matthew D. Zimmerman, Samir Olatunji, Jaeyong Lee, Min Xie, Jansy Sarathy, Martin Caffrey, Natalie C. J. Strynadka, Véronique Dartois, Thomas Dick, Bom Nae Rin Lee, David G. Russell, Eric Oldfield
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::795aa2e7ce9d04ea62216ba0eca39ed4
https://doi.org/10.1021/acs.jmedchem.3c00398
https://doi.org/10.1021/acs.jmedchem.3c00398
Autor:
Shuqi Li, Nicholas C. Poulton, Jesseon S. Chang, Zachary A. Azadian, Michael A. DeJesus, Nadine Ruecker, Matthew D. Zimmerman, Kathryn A. Eckartt, Barbara Bosch, Curtis A. Engelhart, Daniel F. Sullivan, Martin Gengenbacher, Véronique A. Dartois, Dirk Schnappinger, Jeremy M. Rock
Publikováno v:
Nature Microbiology. 7:766-779
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy is limited by Mtb’s intrinsic drug resistance, as well as its ability to evolve acquired resistance to all antituberculars in clinical use. A deeper un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f52c73c301fb7cfa3028e65af38ad33
https://doi.org/10.1038/s41564-022-01130-y
https://doi.org/10.1038/s41564-022-01130-y
Autor:
Dereje A. Negatu, Rubén González del Río, Mónica Cacho-Izquierdo, David Barros-Aguirre, Joël Lelievre, Joaquín Rullas, Patricia Casado, Uday S. Ganapathy, Matthew D. Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro . Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6668d4f8f3c6b25dd1c8741fce5cef2b
https://doi.org/10.1128/aac.01459-22
https://doi.org/10.1128/aac.01459-22
Autor:
Nicholas D. Walter, Jackie P. Ernest, Christian Dide-Agossou, Allison A. Bauman, Michelle E. Ramey, Karen Rossmassler, Lisa M. Massoudi, Samantha Pauly, Reem Al Mubarak, Martin I. Voskuil, Firat Kaya, Jansy P. Sarathy, Matthew D. Zimmerman, Véronique Dartois, Brendan K. Podell, Radojka M. Savic, Gregory T. Robertson
Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32c2774e6ba237d4dcbaa51a1145d6af
https://doi.org/10.1101/2023.02.03.527062
https://doi.org/10.1101/2023.02.03.527062
Autor:
Jickky Palmae Sarathy, Matthew D. Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick
Publikováno v:
Antimicrobial agents and chemotherapy. 66(12)
The anti-tuberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target retention. OPC-167832 was bactericidal and did not antagonize activity of clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecac7458e367897b6124c559db4800c
https://pubmed.ncbi.nlm.nih.gov/36350151
https://pubmed.ncbi.nlm.nih.gov/36350151