Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Matthew D. Truppo"'
Autor:
Ian White, Ninkka Tamot, Rajitha Doddareddy, Jason Ho, Qun Jiao, Paul B. Harvilla, Tong-Yuan Yang, Brian Geist, M. Jack Borrok, Matthew D. Truppo, Rajkumar Ganesan, Partha Chowdhury, Adam Zwolak
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The global health crisis and economic tolls of COVID-19 necessitate a panoply of strategies to treat SARS-CoV-2 infection. To date, few treatment options exist, although neutralizing antibodies against the spike glycoprotein have proven to be effecti
Externí odkaz:
https://doaj.org/article/a6460b31f1584b1b94ecaa2b69a6345e
Autor:
Edward C. Sherer, Junyong Jo, Holst M. Halsey, Jack Liang, Niki R. Patel, Agustina Rodriguez-Granillo, Christopher C. Nawrat, Aaron M. Whittaker, Canada Keith A, Margie Borra-Garske, Nicholas M. Marshall, Kevin R. Campos, Anna Fryszkowska, Yingju Xu, Paul N. Devine, Shane T. Grosser, Grant S. Murphy, Jovana Nazor, Matthew D. Truppo, Benjamin F. Mann, Jeffrey C. Moore, Sandra A. Robaire, Gregory Hughes, Scott J. Novick, Da Duan, Jacob Forstater, Joshua N. Kolev, Deeptak Verma, Kevin M. Maloney, Oscar Alvizo, Mark A. Huffman, Li Xiao, Mark McLaughlin, Leo A. Joyce, Hao Yang
Publikováno v:
Science. 366:1255-1259
Maximal efficiency from enzyme cascades Enzymes are highly selective catalysts that can be useful for specific transformations in organic synthesis. Huffman et al. combined designer enzymes in a multistep cascade reaction (see the Perspective by O'Re
Autor:
John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani, Jeffrey C. Moore, Nicholas M. Marshall, Margie Borra-Garske, Jennifer V. Obligacion, Patrick S. Fier, Feng Peng, Jacob H. Forstater, Matthew S. Winston, Chihui An, Wonsuk Chang, Jongwon Lim, Mark A. Huffman, Steven P. Miller, Fuh-Rong Tsay, Michael D. Altman, Charles A. Lesburg, Dietrich Steinhuebel, B. Wesley Trotter, Jared N. Cumming, Alan Northrup, Xiaodong Bu, Benjamin F. Mann, Mirlinda Biba, Kaori Hiraga, Grant S. Murphy, Joshua N. Kolev, Amanda Makarewicz, Weilan Pan, Iman Farasat, Rachel S. Bade, Kevin Stone, Da Duan, Oscar Alvizo, Donovan Adpressa, Erik Guetschow, Erik Hoyt, Erik L. Regalado, Steve Castro, Nelo Rivera, Joseph P. Smith, Fengqiang Wang, Alejandro Crespo, Deeptak Verma, Stephanus Axnanda, Zachary E. X. Dance, Paul N. Devine, David Tschaen, Keith A. Canada, Paul G. Bulger, Benjamin D. Sherry, Matthew D. Truppo, Rebecca T. Ruck, Louis-Charles Campeau, David Jonathan Bennett, Guy R. Humphrey, Kevin R. Campos, Matthew L. Maddess
Publikováno v:
Nature. 603(7901)
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multi
Autor:
Paul B. Harvilla, Ninkka Tamot, Adam Zwolak, Jason Ho, Matthew D. Truppo, Rajitha Doddareddy, Tong-Yuan Yang, M. Jack Borrok, Ian White, Chowdhury Partha, Qun Jiao, Rajkumar Ganesan, Brian Geist
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The global health crisis and economic tolls of COVID-19 necessitate a panoply of strategies to treat SARS-CoV-2 infection. To date, few treatment options exist, although neutralizing antibodies against the spike glycoprotein have proven to be effecti
Autor:
Elisabeth G. Prinslow, Jaclyn M. Hoover, Sherry L. La Porte, Matthew D. Truppo, Jeffrey E. Teigler
Publikováno v:
Remington ISBN: 9780128200070
The last 30 years has seen a dramatic expansion in the development and production of therapeutic antibody products entering clinical trials and attaining approval from the US Food and Drug Administration. The therapeutic antibody discovery process ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f60f6e38b936e0174c805a9aa2f05223
https://doi.org/10.1016/b978-0-12-820007-0.00023-4
https://doi.org/10.1016/b978-0-12-820007-0.00023-4
Autor:
Kamilia Abdelraouf, Anush Abelian, Amos O. Abioye, Adeboye Adejare, Nour Allahham, Purnima D. Amin, Claire Anderson, Tomefa E. Asempa, Zeynep Ates-Alagoz, Atheer Awad, Jungjun Bae, Abdul W. Basit, Sandipan Bhattacharjee, Angela L. Bingham, Asma Buanz, Michael E. Burczynski, Esperanza J. Carcache de Blanco, Michael J. Cawley, Vivianne K. Celario, Lisa M. Cillessen, Geoff Curran, Richard N. Dalby, Lisa E. Davis, Michael Claro Dejos, Chris Delcher, Ankita R. Desai, Ditixa T. Desai, Vivek Vijay Dhawan, Michael Dybek, Grace Earl, Mohamed Elmeliegy, Taiwo Olayemi Elufioye, Mary J. Ferrill, Felix W. Frueh, Simon Gaisford, Jackelyn M. Galiardi, Kimberly A. Galt, Francesca K.H. Gavins, Boyenoh Gaye, Brian Geist, Islam M. Ghazi, Oliver Ghobrial, Eleonora Gianti, Izabela Gierach, Amie Goodin, Paul O. Gubbins, Sharda Gurram, Gregory J. Higby, Jaclyn M. Hoover, Ankitkumar Jain, Bruce Edward Jones, Kaveri Kalola, James M. Kidd, A. Douglas Kinghorn, Geetanjali Laghate, Sherry L. La Porte, Richard Thomas Layer, Maria Leibfried, Song Li, Yan Li, Zhiyu Li, Heather Lyons-Burney, Christine M. Madla, Mohammed Maniruzzaman, Brian Marshall, T. Joseph Mattingly, Furqan A. Maulvi, Annette McFarland, Mala Menon, Andrew W. Mina, Pinal Mistry, Daniela Moga, Monica Muñoz, Mangal Shailesh Nagarsenkar, Isha Naik, David J. Newman, Jeffrey P. Norenberg, Brian R. Overholser, Jacob T. Painter, Michelle Parker, Nathan Pauly, Jaywant Pawar, Amy Sutton Peak, Andrew M. Peterson, Laura T. Pizzi, Varsha Pokharkar, Stuart C. Porter, Divya Prabhudesai, Elisabeth G. Prinslow, Bahijja Tolulope Raimi-Abraham, Ketan M. Ranch, Michael S. Saporito, Hemali Savla, Krutika Khanderao Sawant, Devanshi S. Shah, Heeshma Shah, Manish R. Shukla, David M. Silverman, Carmela M. Silvestri, Pirthi Pal Singh, Minji Sohn, Diana M. Solomon, Kevin M. Sowinski, Jeffrey E. Teigler, Sarah J. Trenfield, Matthew D. Truppo, Benjamin Y. Urick, Daniel J. Ventricelli, Jason Wallach, Bing Wang, Gareth R. Williams, Karl G. Williams, David W. Wood, Jieni Xu, Yan Xu, Jing Yuan, Randy J. Zauhar, Songmao Zheng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c11c3a5c2cc76b4941c3242c9f91525
https://doi.org/10.1016/b978-0-12-820007-0.00058-1
https://doi.org/10.1016/b978-0-12-820007-0.00058-1
Autor:
Kaori Hiraga, Katrina W. Lexa, Alejandro Crespo, Matthew D. Truppo, Agustina Rodriguez-Granillo, Sridhar Govindarajan, Mark D. Welch, Jeffrey C. Moore, Nicholas M. Marshall
Publikováno v:
ACS Synthetic Biology. 7:1730-1741
Directed evolution experiments designed to improve the activity of a biocatalyst have increased in sophistication from the early days of completely random mutagenesis. Sequence-based and structure-based methods have been developed to identify "hotspo
Autor:
Feng Xu, Matthew D. Truppo, Hongming Li, Zhiguo J. Song, Yong-Li Zhong, Rebecca T. Ruck, Richard Desmond, Ji Qi, Tao Wang, Guy R. Humphrey, Jeonghan Park
Publikováno v:
Organic Letters. 19:5880-5883
A practical and asymmetric synthesis of a functionalized trans-cyclopropoxy building block for the preparation of the HCV NS3/4a protease inhibitor grazoprevir is reported. Intramolecular SN2 displacement–ring closure, followed by a Baeyer–Villig
Autor:
Matthew D. Truppo
Publikováno v:
ACS Medicinal Chemistry Letters. 8:476-480
The use of biocatalysis in the pharmaceutical industry continues to expand as a result of increased access to enzymes and the ability to engineer those enzymes to meet the demands of industrial processes. However, we are still just scratching the sur
Autor:
Spencer D. Dreher, Nicholas K. Terrett, Emma R. Parmee, Matthew D. Truppo, Richard D. Tillyer, Robert M. Garbaccio, Kevin R. Campos, Juan C. Alvarez, Paul J. Coleman
Publikováno v:
Science (New York, N.Y.). 363(6424)
BACKGROUND Over the past century, innovations in synthetic chemistry have greatly enabled the discovery and development of important life-changing medicines, improving the health of patients worldwide. In recent years, many pharmaceutical companies h