Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Matthew D. Troutman"'
Publikováno v:
ACS chemical biology. 16(8)
Stability proteomics techniques that do not require drug modifications have emerged as an attractive alternative to affinity purification methods in drug target engagement studies. Two representative techniques include the chemical-denaturation-based
Autor:
Claire M. Steppan, Hui Zhang, Lisa Aschenbrenner, Chang Liu, Lucien P. Ghislain, Lorraine F. Lanyon, Stephen Noell, Mike West, Jianhua Liu, Thomas R. Covey, Matthew D. Troutman, Kenneth J. DiRico, Wenyi Hua, Sammy S Datwani, Don W. Arnold
Publikováno v:
Analytical chemistry. 93(31)
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI)-MS that creates a transformative system enabl
Autor:
Don W. Arnold, Jianhua Liu, Chang Liu, Lucien P. Ghislain, Lisa Aschenbrenner, Lorraine F. Lanyon, Matthew D. Troutman, Wenyi Hua, Stephen Noell, Claire M. Steppan, Hui Zhang, Thomas R. Covey, Kenneth J. DiRico, Sammy S Datwani
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI) MS that creates a transformative system enabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703c8556217136f2c5ea488b12069005
Publikováno v:
Drug-Drug Interactions ISBN: 9780429131967
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fb1889336735942663a38dbc5f947f0
https://doi.org/10.1201/9780429131967-8
https://doi.org/10.1201/9780429131967-8
Autor:
Anthony Carlo, Bo Feng, Mark A. West, Jennifer L. Liras, Nandini Chaturbhai Patel, Thomas Y. K. Lau, Travis T. Wager, Matthew D. Troutman, Patrick Trapa, John P. Umland, Tristan S. Maurer
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(4)
Understanding the quantitative implications of P-glycoprotein and breast cancer resistance protein efflux is a key hurdle in the design of effective, centrally acting or centrally restricted therapeutics. Previously, a comprehensive physiologically b
Autor:
Li Di, R. Scott Obach, Cexiong Fu, Catherine Soderstrom, Hui Zhang, Xiaogang Han, Mark Snyder, Matthew D. Troutman
Publikováno v:
Drug Metabolism and Disposition. 41:1797-1804
Aldehyde oxidase 1 (AOX1) is a cytosolic enzyme highly expressed in liver and plays a key role in metabolizing drugs containing aromatic azaheterocyclic substituents. Rapid metabolism catalyzed by AOX1 can cause a drug to exhibit high clearance, low
Autor:
Kuang Tongtao, Wang Zhibo, Yuanqiang Long, Jian Li, Xin Ran, Jinshan Chen, David W. Piotrowski, Hua Yi, Cristiano Ruch Werneck Guimarães, Chonggang Liu, Frank Rong, Shai Li, Heather N. Frost, Guoyun Bai, Junwei Shen, Jieyang Tan, James Federico, Hua Yu, Kexin Xu, Li Chen, Liu Bo, Ai Chaowu, Yingfu Li, Chen Yuanwei, Zhilong Jiang, Geng Xi, Hongyun Qiao, Carrie Whitney-Pickett, Magee Thomas Victor, Bo Shan, Kai Wu, Matthew D. Troutman, Mark C. Noe, Dale Gordon Mcleod, Youpei Chen, Jing Du, Gilles H. Goetz, Dapeng Zhao, Qiu Gao, Li Xiaoyong, Changqing Shi
Publikováno v:
Tetrahedron Letters. 54:3298-3301
We report novel syntheses of 12-membered macrocyclic templates and a library of 4000 macrocyclic analogs. The key macrocyclization step was performed at up to 100 g scale without resorting to syringe pumps, flow reactors or large volumes of solvent.
Autor:
Hui Zhang, Russ Smith, Caroline A. Lee, Manthena V.S. Varma, Matthew D. Troutman, Charles J. Rotter, James Federico, Theodore E. Liston, Sarah Kempshall, Katherine S. Fenner, Ralph E. Davidson, Xun Zhang, John P. Umland, Carrie Whitney-Pickett, Li Di, Bo Feng, Yurong Lai, Ayman El-Kattan, Eric L. Reyner, David F. Gebhard
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4974-4985
Permeability is an important property of drug candidates. The Madin-Darby canine kidney cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK cells is the presence of endogenous transporters of nonhuman origin. The
Autor:
Matthew D. Troutman, John P. Umland, Li Di, Theodore E. Liston, Dennis O. Scott, Youping Huang, Zhen J Lin, George Chang
Publikováno v:
Drug Metabolism and Disposition. 39:1270-1277
Species independence of brain tissue binding was assessed with a large number of structurally diverse compounds using equilibrium dialysis with brain homogenates of seven species and strains (Wistar Han rat, Sprague-Dawley rat, CD-1 mouse, Hartley gu
Autor:
Stefanus J. Steyn, R. Scott Obach, George Chang, Matthew D. Troutman, Howard Miller, Charles J. Rotter, Manthena V.S. Varma, Ayman El-Kattan
Publikováno v:
Journal of Medicinal Chemistry. 53:1098-1108
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database comprised of Fa, Fg, Fh, and F values for 309 drugs in human