Výsledky vyhledávání - "Matthew D. Marsden"

Akademický článek

HIV Persistence, Latency, and Cure Approaches: Where Are We Now?

Autor: Tessa C. Chou, Nishad S. Maggirwar, Matthew D. Marsden

Publikováno v: Viruses, Vol 16, Iss 7, p 1163 (2024)

The latent reservoir remains a major roadblock to curing human immunodeficiency virus (HIV) infection. Currently available antiretroviral therapy (ART) can suppress active HIV replication, reduce viral loads to undetectable levels, and halt disease p

Externí odkaz: https://doaj.org/article/b08608cf97be4bedb654f14ec4e9061b

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Akademický článek

Latency reversal plus natural killer cells diminish HIV reservoir in vivo

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Here, Kim et al. describe a new kick and kill strategy utilizing a single administration of a protein kinase C modulator and latency reversing agent in combination with injections of allogeneic peripheral blood natural killer cells diminishes the HIV

Externí odkaz: https://doaj.org/article/7b9b98b368d54eccabea67b1cb3df389

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Akademický článek

Contribution of Sex Differences to HIV Immunology, Pathogenesis, and Cure Approaches

Autor: Jose A. Moran, Shireen R. Turner, Matthew D. Marsden

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Approximately 38 million people were living with human immunodeficiency virus (HIV) in 2020 and 53% of those infected were female. A variety of virological and immunological sex-associated differences (sexual dimorphism) in HIV infection have been re

Externí odkaz: https://doaj.org/article/295fd5ec318a4046a98fb1ee231d406e

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Akademický článek

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

Autor: Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cel

Externí odkaz: https://doaj.org/article/ebe37911de374c93a36c1ee604f378a0

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Akademický článek

Benefits and limitations of humanized mice in HIV persistence studies

Autor: Matthew D. Marsden

Publikováno v: Retrovirology, Vol 17, Iss 1, Pp 1-6 (2020)

Abstract Significant advances in the treatment of HIV infection have been made in the last three decades. Antiretroviral therapy (ART) is now potent enough to prevent virus replication and stop disease progression. However, ART alone does not cure th

Externí odkaz: https://doaj.org/article/2dc8b57a269b452f9b07e9da4cae70af

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Akademický článek

Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

Autor: Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda

Publikováno v: Cell Reports Medicine, Vol 1, Iss 3, Pp 100037- (2020)

Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells. We have previously reported that induc

Externí odkaz: https://doaj.org/article/844b2284d4654ae7b526e217e79fb151

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