Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Matthew D. Lloyd"'
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 299 (2024)
α-Methylacyl-CoA racemase in M. tuberculosis (MCR) has an essential role in fatty acid metabolism and cholesterol utilization, contributing to the bacterium’s survival and persistence. Understanding the enzymatic activity and structural features o
Externí odkaz:
https://doaj.org/article/d66d65e2902d46ff934b3d658be25e44
Autor:
Vega Widya Karisma, Wei Wu, Mingxing Lei, Huawen Liu, Muhammad Farrukh Nisar, Matthew D. Lloyd, Charareh Pourzand, Julia Li Zhong
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light
Externí odkaz:
https://doaj.org/article/2daa0fbbf286444d933909b4b55a1937
Autor:
Timothy Searls, Danica Butler, Winnie Chien, Mridul Mukherji, Matthew D. Lloyd, Christopher J. Schofield
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 8, Pp 1660-1667 (2005)
The mature form of phytanoyl-coenzyme A 2-hydroxylase (PAHX), a nonheme Fe(II)- and 2-oxoglutarate-dependent oxygenase, catalyzes the α-hydroxylation of phytanoyl-CoA within peroxisomes. Mutations in PAHX result in some forms of adult Refsum's disea
Externí odkaz:
https://doaj.org/article/60cef5c4d0704254935a7959317f6b02
Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease
Autor:
Anthony S. Wierzbicki, Phillip D. Mayne, Matthew D. Lloyd, David Burston, Guam Mei, Margaret C. Sidey, Michael D. Feher, F. Brian Gibberd
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 8, Pp 1481-1488 (2003)
Adult Refsum disease (ARD) is associated with defective α-oxidation of phytanic acid (PA). ω-Oxidation of PA to 3-methyl-adipic acid (3-MAA) occurs although its clinical significance is unclear. In a 40 day study of a new ARD patient, where the pla
Externí odkaz:
https://doaj.org/article/a7f9340b180b4258bfe9d4d09a71c4e5
Publikováno v:
Inorganic Chemistry. 62:4503-4513
Autor:
Matthew D. Lloyd
Publikováno v:
The Biochemist. 43:40-45
Steady-state enzyme kinetics is a cornerstone technique of biochemistry and related sciences since it allows the characterization and quantification of enzyme behaviour. Enzyme kinetics is widely used to investigate the physiological role of enzymes,
Autor:
Michael D. Threadgill, Matthew D. Lloyd, Timothy J. Woodman, Tony D. James, Maksims Yevglevskis, Amit Nathubhai
Publikováno v:
Chemical Society Reviews
Racemases and epimerases catalyse changes in the stereochemical configurations of chiral centres and are of interest as model enzymes and as biotechnological tools. They also occupy pivotal positions within metabolic pathways and, hence, many of them
Autor:
Matthew D. Lloyd
Publikováno v:
Lloyd, M 2020, ' High-Throughput Screening For The Discovery Of Enzyme Inhibitors ', Journal of Medicinal Chemistry, vol. 63, no. 19, pp. 10742–10772 . https://doi.org/10.1021/acs.jmedchem.0c00523
Enzymes are common targets in high-throughput screening and related campaigns. An analysis of papers published between 1990 and 2018 showed that kinases were the most common enzymes investigated, fluorescence-based assays were the most common read-ou
Autor:
Charareh Pourzand, Jun Lu, Jing Li, Ping Cheng, Shoufeng Li, Xiaoyuan Ren, Julia Li Zhong, Matthew D. Lloyd, Pengfei Zhao, Bing Han, Arne Holmgren
Publikováno v:
Li, J, Cheng, P, Li, S, Zhao, P, Han, B, Ren, X, Zhong, J L, Lloyd, M D, Pourzand, C, Holmgren, A & Lu, J 2021, ' Selenium status in diet affects acetaminophen-induced hepatotoxicity via interruption of redox environment ', Antioxidants & Redox Signaling, vol. 34, no. 17, pp. 1355-1368 . https://doi.org/10.1089/ars.2019.7909
Aims: Drug-induced liver injury, especially acetaminophen (APAP)-induced liver injury, is a leading cause of liver failure worldwide. Mouse models were used to evaluate the effect of microelement selenium levels on the cellular redox environment and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb6200c0e3c54c54ce9f6354444473e
https://purehost.bath.ac.uk/ws/files/205847065/Li_et_al._2020.pdf
https://purehost.bath.ac.uk/ws/files/205847065/Li_et_al._2020.pdf
Autor:
Vega Widya Karisma, Wei Wu, Mingxing Lei, Huawen Liu, Muhammad Farrukh Nisar, Matthew D. Lloyd, Charareh Pourzand, Julia Li Zhong
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light