Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Matthew D. Harwood"'
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Akademický článek
Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework
Autor: Aneesh V. Karkhanis, Matthew D. Harwood, Felix Stader, Frederic Y. Bois, Sibylle Neuhoff
Publikováno v: Pharmaceutics, Vol 16, Iss 10, p 1284 (2024)
Background/Objectives: Plasma levels of 4β-hydroxycholesterol (4β-OHC), a CYP3A-specific metabolite of cholesterol, are elevated after administration of CYP3A inducers like rifampicin and carbamazepine. To simulate such plasma 4β-OHC increase, we
Externí odkaz: https://doaj.org/article/196f7ff56933489ebead894d0428330a
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3
Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics
Autor: Amin Rostami-Hodjegan, Jill Barber, Gordon L Carlson, Narciso Couto, Zubida M. Al-Majdoub, Matthew D Harwood, Brahim Achour, Geoffrey Warhurst
Publikováno v: Clinical Pharmacology and Therapeutics
Al-Majdoub, Z, Couto, N, Achour, B, Harwood, M D, Carlson, G, Warhurst, G, Barber, J & Rostami-Hodjegan, A 2021, ' Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics ', Clinical Pharmacology & Therapeutics, vol. 109, no. 4, pp. 1136-1146 . https://doi.org/10.1002/cpt.2097
The intestinal epithelium represents a natural barrier against harmful xenobiotics, whilst facilitating the uptakeof nutrients and other substances. Understanding the interaction of chemicals with constituents of theintestinal epithelium and their fa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9783d9ffb9979685b70835a0ca42ee
https://doi.org/10.1002/cpt.2097
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4
Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine
Autor: Stephanie L Gibson, Gordon L Carlson, P. Davies, Zubida M. Al-Majdoub, Matthew D Harwood, Brahim Achour, Geoffrey Warhurst, Jill Barber, Amin Rostami-Hodjegan, Narciso Couto
Publikováno v: Drug Metabolism and Disposition
Drug Metab Dispos
The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on such measurements, it is well recognized that these values are esse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4d21e6154864c277c98ec478eecfff
http://europepmc.org/articles/PMC7076527
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5
The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis
Autor: Mian Zhang, Matthew D Harwood, Sibylle Neuhoff, Shriram M. Pathak
Publikováno v: Drug Metabolism and Disposition. 47:854-864
The aim of this study was to derive region-specific transporter expression data suitable for in vitro-to-in vivo extrapolation (IVIVE) within a physiologically based pharmacokinetic (PBPK) modeling framework. A meta-analysis was performed whereby lit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcff7000d7fadd7372439986e851e16
https://doi.org/10.1124/dmd.119.086959
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6
Application of proteomic data in the translation of in vitro observations to associated clinical outcomes
Autor: Matthew D Harwood, Sibylle Neuhoff, Brahim Achour, Amin Rostami-Hodjegan
Publikováno v: Neuhoff, S, Harwood, M, Rostami-Hodjegan, A & Achour, B 2021, ' Application of proteomic data in the translation of in vitro observations to associated clinical outcomes ', Drug Discovery Today: Technologies, vol. 39, pp. 13-22 . https://doi.org/10.1016/j.ddtec.2021.06.002
Translation of information on drug exposure and effect is facilitated by in silico models that enable extrapolation of in vitro measurements to in vivo clinical outcomes. These models integrate drug-specific data with information describing physiolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f435338e279a24be850c414b8d8212d
https://pubmed.ncbi.nlm.nih.gov/34906322
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7
Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis
Autor: Howard Burt, Matthew D Harwood, Sibylle Neuhoff, Katherine L. Gill, H. Kim Crewe, Arian Emami Riedmaier
Publikováno v: Drug Metabolism and Disposition
This study aimed to derive quantitative abundance values for key hepatic transporters suitable for in vitro–in vivo extrapolation within a physiologically based pharmacokinetic modeling framework. A meta-analysis was performed whereby data on abund
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b20acf484bdeb6da46069d97924af1d
https://doi.org/10.1124/dmd.116.071183
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In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
Autor: Sibylle Neuhoff, Geoffrey Warhurst, Matthew D Harwood, Gordon L Carlson, Brahim Achour, Amin Rostami-Hodjegan, Matthew R. Russell
Publikováno v: University of Manchester-PURE
Relative expression factors (REFs) are used to scale in vitro transporter kinetic data via in vitro-in vivo extrapolation linked to physiologically based pharmacokinetic (IVIVE-PBPK) models to clinical observations. Primarily two techniques to quanti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cded8f82dbd876b374c1da30a66f166e
https://doi.org/10.1124/dmd.115.067777
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9
Application of an LC–MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique
Autor: Matthew R. Russell, Geoffrey Warhurst, Brahim Achour, Matthew D Harwood, Gordon L Carlson, Amin Rostami-Hodjegan
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 110:27-33
Transporter proteins expressed in the gastrointestinal tract play a major role in the oral absorption of some drugs, and their involvement may lead to drug–drug interaction (DDI) susceptibility when given in combination with drugs known to inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0213ec873d1d9d7c80efb9eecdd2b703
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10
The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model
Autor: Helen Musther, Jiansong Yang, David B. Turner, Matthew D Harwood, Masoud Jamei, Amin Rostami-Hodjegan
Publikováno v: Musther, H, Harwood, M D, Yang, J, Turner, D B, Rostami-Hochaghan, A & Jamei, M 2017, ' The Constraints, Construction and Verification of a Strain-Specific Physiologically-Based Pharmacokinetic Rat Model ', Journal of Pharmaceutical Sciences, pp. 1-13 . https://doi.org/10.1016/j.xphs.2017.05.003
The use of in vitro – in vivo extrapolation (IVIVE) techniques, mechanistically incorporated within physiologically based pharmacokinetic (PBPK) models, can harness in vitro drug data and enhance understanding of in vivo pharmacokinetics. This stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617c46a1f2050b60b3227daae1c14c15
https://pubmed.ncbi.nlm.nih.gov/28495566
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