Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Matthew D. Gallovic"'
Autor:
Rebeca T, Stiepel, Erik S, Pena, Stephen A, Ehrenzeller, Matthew D, Gallovic, Liubov M, Lifshits, Christopher J, Genito, Eric M, Bachelder, Kristy M, Ainslie
Publikováno v:
Journal of Controlled Release. 351:883-895
Effective drug delivery requires ample dosing at the target tissue while minimizing negative side effects. Drug delivery vehicles such as polymeric nanoparticles (NPs) are often employed to accomplish this challenge. In this work, drug release of num
Autor:
Matthew D. Gallovic, Robert D. Junkins, Adam M. Sandor, Erik S. Pena, Christopher J. Sample, Ariel K. Mason, Leslee C. Arwood, Rebecca A. Sahm, Eric M. Bachelder, Kristy M. Ainslie, Gregory D. Sempowski, Jenny P.-Y. Ting
Publikováno v:
J Control Release
The COVID-19 pandemic highlights the need for effective vaccines against respiratory viruses. An ideal vaccine should induce robust and long-lasting responses with high manufacturing scalability. We used an adjuvant comprised of a Stimulator of Inter
Autor:
Cole J. Batty, Matthew D. Gallovic, Jonathan Williams, Ted M. Ross, Eric M. Bachelder, Kristy M. Ainslie
Publikováno v:
Int J Pharm
Subunit vaccines employing designer antigens such as Computationally Optimized Broadly Reactive Antigen (COBRA) hemagglutinin (HA) hold the potential to direct the immune response toward more effective and broadly-neutralizing targets on the Influenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6663d46d44965d658a74b4cc365a139
https://europepmc.org/articles/PMC9484837/
https://europepmc.org/articles/PMC9484837/
Autor:
Jenny P.-Y. Ting, Eric M. Bachelder, Pamela Tiet, Matthew D. Gallovic, Kristy M. Ainslie, Naihan Chen
Publikováno v:
Journal of Controlled Release. 289:114-124
Influenza places a significant health and economic burden on society. Efficacy of seasonal influenza vaccines can be suboptimal due to poor matching between vaccine and circulating viral strains. An influenza vaccine that is broadly protective agains
Autor:
Matthew D. Gallovic, Sara A. Gibson, Brandon M. Johnson, Kristy M. Ainslie, Jonathan W. Williams, Wei-Chun Chou, Cole J. Batty, Jenny P.-Y. Ting, Glenn K. Matsushima, Eric M. Bachelder, Meng Deng, Jason W. Tam, Toru Uchimura, Silva Markovic-Plese, Madhan Thamilarasan
Publikováno v:
J Immunol
The cGAS–cyclic GMP–AMP (cGAMP)–stimulator of IFN genes (STING) pathway induces a powerful type I IFN (IFN-I) response and is a prime candidate for augmenting immunity in cancer immunotherapy and vaccines. IFN-I also has immune-regulatory funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c282d3bd55213316e3585e70877c11c5
https://europepmc.org/articles/PMC8406342/
https://europepmc.org/articles/PMC8406342/
Autor:
Kevin J. Peine, Hassan Borteh, Saibal Bandyopadhyay, Kristy M. Ainslie, Barbara E. Wyslouzil, Douglas G. Montjoy, Matthew D. Gallovic, Eric M. Bachelder, Michael A. Collier
Publikováno v:
Journal of materials chemistry. B. 4(24)
Acid-degradable polymers are well-suited for use as drug delivery vehicles because numerous physiological sites (e.g., intracellular endocytic pathway) are acidic. Here we report the synthesis of acid-sensitive silylated polysaccharides derived from
Autor:
Rebekah Watkins-Schulz, Pamela Tiet, Cole J. Batty, Jenny P.-Y. Ting, Robert D. Junkins, Kristy M. Ainslie, Eric M. Bachelder, Matthew D. Gallovic
Immunotherapies have significantly improved cancer patient survival, but response rates are still limited. Thus, novel formulations are needed to expand the breadth of immunotherapies. Pathogen associated molecular patterns (PAMPs) can be used to sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd78adbd5ed86ac6967ebe959deb6e3
https://europepmc.org/articles/PMC6594365/
https://europepmc.org/articles/PMC6594365/
Autor:
Elizabeth Q. Fernandes, Kristy M. Ainslie, Naihan Chen, Carla Coste Sanchez, Graham C. Collins, Matthew D. Gallovic, Michael A. Collier, Eric M. Bachelder
Publikováno v:
International Journal of Pharmaceutics. 512:147-157
Microparticles (MPs) derived from acid-sensitive biopolymers enable rapid degradation and cargo release under acidic conditions, such as at tumor microenvironments, within lysosomal/phagosomal compartments inside phagocytic cells, or at sites of infl
Autor:
Matthew G. Bell, Andrea M. Keane-Myers, Margaret A. Elberson, Eric M. Bachelder, Christian A. Darko, Kevin L. Schully, Kristy M. Ainslie, Barbara E. Wyslouzil, John R. Palmer, Matthew D. Gallovic
Publikováno v:
Advanced Healthcare Materials. 5:2617-2627
Subunit formulations are regarded as the safest type of vaccine, but they often contain a protein-based antigen that can result in significant challenges, such as preserving antigenicity during formulation and administration. Many studies have demons
Autor:
Matthew G. Bell, Sadhana Sharma, Kristy M. Ainslie, Andrea M. Keane-Myers, M.A. Elberson, Eric M. Bachelder, Kevin L. Schully, John T. Pesce, Kevin J. Peine, Shalini Gautam, Angela M. Prouty, Matthew D. Gallovic
Publikováno v:
International Journal of Pharmaceutics. 495:849-861
Melioidosis, a potentially lethal disease of humans and animals, is caused by the soil-dwelling bacterium Burkholderia pseudomallei. Due to B. pseudomallei's classification as a Tier 1 Select Agent, there is substantial interest in the development of