Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Matthew D. Fodor"'
Autor:
Matthew D. Fodor, Thomas S. Hughes
Publikováno v:
Journal of Physical Organic Chemistry. 35
Publikováno v:
Journal of Chemical Education. 95:1230-1234
Torsional effects influence kinetic selectivity in a wide range of organic transformations. As such, textbooks commonly use Newman projections to illustrate the torsional effects that arise in their transition states. Unfortunately, these representat
Autor:
Jetze J. Tepe, Shun Su, Ken S. Feldman, Amanda P. Skoumbourdis, Matthew D. Fodor, Ian B. Seiple, Theresa A. Lansdell, Nicole M. Hewlett, Phil S. Baran
Publikováno v:
Journal of Natural Products. 75:980-985
We report herein that the oroidin-derived alkaloids palau'amine (1), dibromophakellin (2), and dibromophakellstatin (3) inhibit the proteolytic activity of the human 20S proteasome as well as the (i)20S immunoproteasome catalytic core. Palau'amine is
Publikováno v:
Synthesis. 2009:3162-3173
A putative biosynthesis proposal for oroidin-derived marine alkaloids serves as a template for developing a biomimetic strategy for the syntheses of tetracyclic members of the phakellin family of sponge metabolites. Pummerer chemistry triggers the ox
Autor:
Stefan Werner, Branko Mitasev, Leslie A. Twining, Matthew D. Fodor, Claire M. Coleman, Pravin S. Iyer, Kay M. Brummond
Publikováno v:
Journal of Combinatorial Chemistry. 8:368-380
The solution phase synthesis of a discovery library of 178 tricyclic pyrrole-2-carboxamides was accomplished in nine steps and seven purifications starting with three benzoyl protected amino acid methyl esters. Further diversity was introduced by two
Autor:
Matthew D. Fodor, Ken S. Feldman
Publikováno v:
The Journal of organic chemistry. 74(9)
The sponge-derived alkaloid dibromoagelaspongin was prepared from a dihydrooroidin derivative by exploiting the Pummerer reaction twice in succession. Oxidative cyclization of the substrate's pyrrole-2-carboxamide function into the imidazole moiety w
Autor:
Claire M. Coleman, Matthew D. Fodor, Pravin S. Iyer, Jelena M. Janjic, Billy W. Day, Peter Wipf, Corey R. J. Stephenson, and Christopher Kendall, Yvonne A. Shafer
Publikováno v:
ChemInform. 36
Cascade reactions of internal and terminal alkynes, zirconocene hydrochloride, dimethylzinc, and phosphinoyl imines (prepared in one step from aldehydes and diphenylphosphinoyl amide) lead to allylic phosphinoyl amides after aqueous workup. Microwave
Extending Pummerer Reaction Chemistry. Application to the Total Synthesis of (±)-Dibromoagelaspongin
Autor:
Ken S. Feldman, Matthew D. Fodor
Publikováno v:
Journal of the American Chemical Society. 130:14964-14965
The sponge metabolite dibromoagelaspongin was synthesized in 16 steps from imidazole. The route features two successive oxidative cyclizations with complete control of regiochemistry to deliver the unusual triaminomethane core of the target. These ox
Autor:
Ken S. Feldman, Matthew D. Fodor
Publikováno v:
Synfacts. 2009:0365-0365