Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthew D. Figley"'
Autor:
Tong Wu, Jian Zhu, Amy Strickland, Kwang Woo Ko, Yo Sasaki, Caitlin B. Dingwall, Yurie Yamada, Matthew D. Figley, Xianrong Mao, Alicia Neiner, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109872- (2021)
Summary: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds, the TIR domai
Externí odkaz:
https://doaj.org/article/de9f3f8581274b08b0ab0cc8ca1a999f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Toll/interleukin-1 receptor (TIR) domain is the signature signalling motif of innate immunity, with essential roles in innate immune signalling in bacteria, plants, and animals. TIR domains canonically function as scaffolds, with stimulus-depende
Externí odkaz:
https://doaj.org/article/b014469dd9ab49198098546905354070
Autor:
Aaron DiAntonio, Matthew D. Figley
Publikováno v:
Current Opinion in Neurobiology. 63:59-66
Axons are essential for nervous system function and axonal pathology is a common hallmark of many neurodegenerative diseases. Over a century and a half after the original description of Wallerian axon degeneration, advances over the past five years h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::424f5d7f584deb5fe788ac72fff030e2
https://doi.org/10.1016/j.conb.2020.02.012
https://doi.org/10.1016/j.conb.2020.02.012
Autor:
Yurie Yamada, Tong Wu, Jeffrey Milbrandt, Amy Strickland, Kwang Woo Ko, Matthew D. Figley, Alicia Neiner, Jian Zhu, Aaron DiAntonio, Xianrong Mao, Caitlin B. Dingwall, Yo Sasaki, A. Joseph Bloom
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109872-(2021)
Cell Rep
Cell Rep
SUMMARYSARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds, the TIR domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867fed9ee01fe23f6560a3abd2fefa32
http://www.sciencedirect.com/science/article/pii/S2211124721013395
http://www.sciencedirect.com/science/article/pii/S2211124721013395
Autor:
Chen Shen, Yo Sasaki, Jeffrey Milbrandt, Pengfei Zhang, Aaron DiAntonio, Xianrong Mao, Matthew D. Figley, Hao Wu, Jian Zhu, Mihir Vohra
Publikováno v:
Proc Natl Acad Sci U S A
Axon degeneration is an active program of self-destruction mediated by the protein SARM1. In healthy neurons, SARM1 is autoinhibited and, upon injury autoinhibition is relieved, activating the SARM1 enzyme to deplete NAD(+) and induce axon degenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec171d84e962b8a29d668a4ba8e46e17
https://pubmed.ncbi.nlm.nih.gov/33468661
https://pubmed.ncbi.nlm.nih.gov/33468661
Autor:
Matthew D, Figley, Weixi, Gu, Jeffrey D, Nanson, Yun, Shi, Yo, Sasaki, Katie, Cunnea, Alpeshkumar K, Malde, Xinying, Jia, Zhenyao, Luo, Forhad K, Saikot, Tamim, Mosaiab, Veronika, Masic, Stephanie, Holt, Lauren, Hartley-Tassell, Helen Y, McGuinness, Mohammad K, Manik, Todd, Bosanac, Michael J, Landsberg, Philip S, Kerry, Mehdi, Mobli, Robert O, Hughes, Jeffrey, Milbrandt, Bostjan, Kobe, Aaron, DiAntonio, Thomas, Ve
Publikováno v:
Neuron. 109(7)
Axon degeneration is a central pathological feature of many neurodegenerative diseases. Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::850dd49db6faec49e9f5dd7ffea7ec3f
https://pubmed.ncbi.nlm.nih.gov/33831359
https://pubmed.ncbi.nlm.nih.gov/33831359
Autor:
Aaron DiAntonio, Raul Krauss, Todd Bosanac, Yo Sasaki, Rajesh V. Devraj, Jeffrey Milbrandt, Tong Wu, Thomas M. Engber, Robert Hughes, Matthew D. Figley
Publikováno v:
Exp Neurol
SARM1 is the central executioner of pathological axon degeneration, promoting axonal demise in response to axotomy, traumatic brain injury, and neurotoxic chemotherapeutics that induce peripheral neuropathy. SARM1 is an injury-activated NAD(+) cleava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a434f8e1d4065f92f5cadb8346e9d9c
https://europepmc.org/articles/PMC7302925/
https://europepmc.org/articles/PMC7302925/
Autor:
Todd Bosanac, Michael J. Landsberg, Yo Sasaki, Jeffrey Milbrandt, Xinying Jia, Helen Ying McGuinness, Katie Cunnea, Matthew D. Figley, Lauren E. Hartley-Tassell, Mehdi Mobli, Veronika Masic, Jeffrey D. Nanson, R.O. Hughes, W. Gu, Zhenyao Luo, Stephanie Jane Holt, Philip S. Kerry, Alpeshkumar K. Malde, Bostjan Kobe, Aaron DiAntonio, M.K. Manik, Tamim Mosaiab, Forhad Karim Saikot, Thomas Ve, Yun Shi
Publikováno v:
Neuron. 109:1118-1136.e11
Axon degeneration is a central pathological feature of many neurodegenerative diseases. Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD+)-cleaving enzyme whose activation triggers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2609398ee350630625479baa14d2e374
https://doi.org/10.1016/j.neuron.2021.02.009
https://doi.org/10.1016/j.neuron.2021.02.009
Autor:
Aaron D. Gitler, Matthew D. Figley
Publikováno v:
Current Biology. 25:R728-R731
SummaryTDP-43 is a key disease protein for amyotrophic lateral sclerosis but how it drives motor neuron degeneration remains unresolved. A new study has modeled TDP-43 age-dependent axonal death in the Drosophila leg and used a powerful forward genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ffb35776c8a85422bba618222862db
https://doi.org/10.1016/j.cub.2015.06.064
https://doi.org/10.1016/j.cub.2015.06.064
Autor:
Clayton A. Wiley, Matthew D. Figley, Huichao Zou, Christian Niyonkuru, Stephanie J. Bissel, Amy K. Wagner, Dafna Bonneh-Barkay, Pavel Zagadailov, Adam Starkey, Guoji Wang
Publikováno v:
Journal of Neurotrauma. 27:1215-1223
YKL-40 (chitinase 3-like protein 1) is expressed in a broad spectrum of inflammatory conditions and cancers. We have previously reported that YKL-40 levels are elevated in the cerebrospinal fluid (CSF) of macaques and humans with lentiviral encephali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd79b10047ddd37ed30861c1877a574d
https://doi.org/10.1089/neu.2010.1310
https://doi.org/10.1089/neu.2010.1310