Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Matthew D. Dun"'
Autor:
Sam Humphries, Danielle R. Bond, Zacary P. Germon, Simon Keely, Anoop K. Enjeti, Matthew D. Dun, Heather J. Lee
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered regulation of DNA methylation is an important epigenetic driver of AML, wh
Externí odkaz:
https://doaj.org/article/d597cb67e38b4e099ab81bff5d446bde
Autor:
Alyssa Noll, Carrie Myers, Matthew C. Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E. Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E.S. Leary, Bonnie L. Cole, Evangeline R. Jackson, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, James M. Olson, Nicholas A. Vitanza
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 43, Iss , Pp 100921- (2023)
Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with the development of hypermutant pediatric high-grade glioma, and confers a poor prognosis. While therapeutic histone deacetylase (HDAC) inhibition of
Externí odkaz:
https://doaj.org/article/8fcbb6db42434d30a54c41c71234e4ad
Autor:
Jessica B. Foster, Marta M. Alonso, Elias Sayour, Tom B. Davidson, Mika L. Persson, Matthew D. Dun, Cassie Kline, Sabine Mueller, Nicholas A. Vitanza, Jasper van der Lugt
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 42, Iss , Pp 100909- (2023)
While immunotherapy for pediatric cancer has made great strides in recent decades, including the FDA approval of agents such as dinutuximab and tisgenlecleucel, these successes have rarely impacted children with pediatric central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/83a724b0107446558a0c82a6d7c6ddff
Autor:
Kooper V. Hunt, Sean M. Burnard, Ellise A. Roper, Danielle R. Bond, Matthew D. Dun, Nicole M. Verrills, Anoop K. Enjeti, Heather J. Lee
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Global changes in DNA methylation are observed in development and disease, and single-cell analyses are highlighting the heterogeneous regulation of these processes. However, technical challenges associated with single-cell analysis of DNA m
Externí odkaz:
https://doaj.org/article/73119636505547c88c866348273eac38
Autor:
Natalie A. Trigg, David A. Skerrett-Byrne, Jacinta H. Martin, Geoffry N. De Iuliis, Matthew D. Dun, Shaun D. Roman, Andrew L. Eamens, Brett Nixon
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108032- (2022)
This article reports the proteomic legacy of in vivo exposure to the xenobiotic, acrylamide, on the epithelial cell population of the proximal segments of the mouse epididymis. Specifically, adult male mice were administered acrylamide (25 mg/kg bw/d
Externí odkaz:
https://doaj.org/article/617b62a60f5d4604bcf836a8e3a423c8
Autor:
Leah Calvert, Mark P. Green, Geoffry N. De Iuliis, Matthew D. Dun, Brett D. Turner, Bradley O. Clarke, Andrew L. Eamens, Shaun D. Roman, Brett Nixon
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
Per-fluoroalkyl and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic fluorinated chemicals used widely in industry and consumer products. Due to their extensive use and chemical stability, PFAS are ubiquitous environmental contamina
Externí odkaz:
https://doaj.org/article/098e2dbc408545178278350272cfca09
Autor:
Natalie A. Trigg, David A. Skerrett-Byrne, Miguel J. Xavier, Wei Zhou, Amanda L. Anderson, Simone J. Stanger, Aimee L. Katen, Geoffry N. De Iuliis, Matthew D. Dun, Shaun D. Roman, Andrew L. Eamens, Brett Nixon
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109787- (2021)
Summary: Paternal exposure to environmental stressors elicits distinct changes to the sperm sncRNA profile, modifications that have significant post-fertilization consequences. Despite this knowledge, there remains limited mechanistic understanding o
Externí odkaz:
https://doaj.org/article/f8d0c118265e452d8c695225b5375140
Autor:
Wei Zhou, Simone J. Stanger, Amanda L. Anderson, Ilana R. Bernstein, Geoffry N. De Iuliis, Adam McCluskey, Eileen A. McLaughlin, Matthew D. Dun, Brett Nixon
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background The mammalian epididymis is responsible for the provision of a highly specialized environment in which spermatozoa acquire functional maturity and are subsequently stored in preparation for ejaculation. Making important contributi
Externí odkaz:
https://doaj.org/article/d95613235ed745e3ab866db445daf2ea
Autor:
Brett Nixon, Ilana R. Bernstein, Shenae L. Cafe, Maryse Delehedde, Nicolas Sergeant, Amanda L. Anderson, Natalie A. Trigg, Andrew L. Eamens, Tessa Lord, Matthew D. Dun, Geoffry N. De Iuliis, Elizabeth G. Bromfield
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Oxidative stress is a leading causative agent in the defective sperm function associated with male infertility. Such stress commonly manifests via the accumulation of pathological levels of the electrophilic aldehyde, 4-hydroxynonenal (4HNE), generat
Externí odkaz:
https://doaj.org/article/7ecc4bb88d25498fa20ae3cf1122467c
Autor:
Olivia Ruhen, Xinyu Qu, M. Fairuz B. Jamaluddin, Carlos Salomon, Aesha Gandhi, Michael Millward, Brett Nixon, Matthew D. Dun, Katie Meehan
Publikováno v:
Membranes, Vol 11, Iss 11, p 880 (2021)
Breast cancer is the leading cause of cancer death in women. The majority of these deaths are due to disease metastasis, in which cancer cells disseminate to multiple organs and disrupt vital physiological functions. It is widely accepted that breast
Externí odkaz:
https://doaj.org/article/596bb57a6da146349d6ad70a9bc8c080