Discovery of Inhibitors for Proliferating Cell Nuclear Antigen Using a Computational-Based Linked-Multiple-Fragment Screen

Autor: Matthew D. Bartolowits, Jonathon M. Gast, Ashlee J. Hasler, Anthony M. Cirrincione, Rachel J. O’Connor, Amr H. Mahmoud, Markus A. Lill, Vincent Jo Davisson

Publikováno v: ACS Omega, Vol 4, Iss 12, Pp 15181-15196 (2019)

Externí odkaz: https://doaj.org/article/589dbfbf1fc54dd2ad2f75f7e80586e4

Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering

Autor: Meiguo Xin, Vincent Jo Davisson, Matthew D. Bartolowits, Thomas J. Tague, Dino P. Petrov

Publikováno v: ACS Omega
ACS Omega, Vol 4, Iss 1, Pp 140-145 (2019)

Isotopic variants of Rhodamine 6G (R6G) have previously been used as a method of multiplexed detection for Surface Enhanced Raman Spectroscopy (SERS), including protein detection and quantification. Challenges exist, however, with producing long-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8091b92a2840a2fa8728606b750d16d
https://doi.org/10.1021/acsomega.8b02970

Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors

Autor: Marsha DeSmet, V. Jo Davisson, Anne Rietz, Dino P. Petrov, Elliot J. Androphy, Matthew D. Bartolowits

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149845 (2016)
PLoS ONE

The human papillomavirus (HPV) HPV E6 protein has emerged as a central oncoprotein in HPV-associated cancers in which sustained expression is required for tumor progression. A majority of the E6 protein interactions within the human proteome use an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9f5b890e15767fc1ce2669fbbf1dcf
http://europepmc.org/articles/PMC4767726?pdf=render

Considerations of Protein Subpockets in Fragment-Based Drug Design

Autor: Matthew D. Bartolowits, V. Jo Davisson

Publikováno v: Chemical biologydrug design. 87(1)

While the fragment-based drug design approach continues to gain importance, gaps in the tools and methods available in the identification and accurate utilization of protein subpockets have limited the scope. The importance of these features of small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856f5f12b322cf6ab15fcdd8e7025cf4
https://pubmed.ncbi.nlm.nih.gov/26307335

Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function

Autor: Jonathan J. Cherry, Elliot J. Androphy, Meng Xie, V. Jo Davisson, James D. Baleja, Anna Malinkevich, Matthew D. Bartolowits, Anne Rietz, Yuqi Liu

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e84506 (2013)
Department of Medicinal Chemistry and Molecular Pharmacology Graduate Student Publications
PLoS ONE

Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor suppressor protein p53 for degradation. To achieve this, "high-risk" HPV E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ff6fc4fdd9b2c2a2bb238919208210
https://doi.org/10.1371/journal.pone.0084506