Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

Autor: Brian D. Reed, Michael J. Meyer, Valentin Abramzon, Omer Ad, Pat Adcock, Faisal R. Ahmad, Gün Alppay, James A. Ball, James Beach, Dominique Belhachemi, Anthony Bellofiore, Michael Bellos, Juan Felipe Beltrán, Andrew Betts, Mohammad Wadud Bhuiya, Kristin Blacklock, Robert Boer, David Boisvert, Norman D. Brault, Aaron Buxbaum, Steve Caprio, Changhoon Choi, Thomas D. Christian, Robert Clancy, Joseph Clark, Thomas Connolly, Kathren Fink Croce, Richard Cullen, Mel Davey, Jack Davidson, Mohamed M. Elshenawy, Michael Ferrigno, Daniel Frier, Saketh Gudipati, Stephanie Hamill, Zhaoyu He, Sharath Hosali, Haidong Huang, Le Huang, Ali Kabiri, Gennadiy Kriger, Brittany Lathrop, An Li, Peter Lim, Stephen Liu, Feixiang Luo, Caixia Lv, Xiaoxiao Ma, Evan McCormack, Michele Millham, Roger Nani, Manjula Pandey, John Parillo, Gayatri Patel, Douglas H. Pike, Kyle Preston, Adeline Pichard-Kostuch, Kyle Rearick, Todd Rearick, Marco Ribezzi-Crivellari, Gerard Schmid, Jonathan Schultz, Xinghua Shi, Badri Singh, Nikita Srivastava, Shannon F. Stewman, TR Thurston, T. R. Thurston, Philip Trioli, Jennifer Tullman, Xin Wang, Yen-Chih Wang, Eric A. G. Webster, Zhizhuo Zhang, Jorge Zuniga, Smita S. Patel, Andrew D. Griffiths, Antoine M. van Oijen, Michael McKenna, Matthew D. Dyer, Jonathan M. Rothberg

Publikováno v: Science. 378:186-192

Studies of the proteome would benefit greatly from methods to directly sequence and digitally quantify proteins and detect posttranslational modifications with single-molecule sensitivity. Here, we demonstrate single-molecule protein sequencing using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d3367086ac787e208c4c79a68cbb83f
https://doi.org/10.1126/science.abo7651

Supplementary Tables 1-6 from AMPKα Modulation in Cancer Progression: Multilayer Integrative Analysis of the Whole Transcriptome in Asian Gastric Cancer

Autor: Garth Powis, Chang-Gong Liu, John N. Weinstein, Sung Hoon Noh, Hyun Cheol Chung, Ellen M. Beasley, Jingtao Sun, Yongming Sun, Matthew D. Dyer, Thomas J. Downey, Min Li, Hoguen Kim, Jae-Ho Cheong, Jae Yong Cho, Ju-Seog Lee, Xiuping Liu, Han Liang, Yon Hui Kim

PDF file - 106K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57d5ca4665991d0d495854da32d00d2
https://doi.org/10.1158/0008-5472.22392776

Network-based prediction and analysis of HIV dependency factors.

Autor: T M Murali, Matthew D Dyer, David Badger, Brett M Tyler, Michael G Katze

Publikováno v: PLoS Computational Biology, Vol 7, Iss 9, p e1002164 (2011)

HIV Dependency Factors (HDFs) are a class of human proteins that are essential for HIV replication, but are not lethal to the host cell when silenced. Three previous genome-wide RNAi experiments identified HDF sets with little overlap. We combine dat

Externí odkaz: https://doaj.org/article/6cd5fa3b0b5145fdbede7699a15f5ccf

P58(IPK): a novel 'CIHD' member of the host innate defense response against pathogenic virus infection.

Autor: Alan G Goodman, Jamie L Fornek, Guruprasad R Medigeshi, Lucy A Perrone, Xinxia Peng, Matthew D Dyer, Sean C Proll, Sue E Knoblaugh, Victoria S Carter, Marcus J Korth, Jay A Nelson, Terrence M Tumpey, Michael G Katze

Publikováno v: PLoS Pathogens, Vol 5, Iss 5, p e1000438 (2009)

To support their replication, viruses take advantage of numerous cellular factors and processes. Recent large-scale screens have identified hundreds of such factors, yet little is known about how viruses exploit any of these. Influenza virus infectio

Externí odkaz: https://doaj.org/article/1dec8dc57f0d4a579e917b21bddfdcdd

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

Autor: Matthew B. Frieman, Matthew D. Dyer, Ralph S. Baric, Gregory A. Zornetzer, Thomas H. Teal, Judith M. A. van den Brand, Bart L. Haagmans, Michael G. Katze, Sean Proll, Tracey Baas, Timothy P. Sheahan, Barry Rockx

Publikováno v: Journal of Virology
Journal of Virology, 83(14), 7062-7074. American Society for Microbiology
Journal of Virology, 83(17), 9022-9022. American Society for Microbiology
Europe PubMed Central

Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain poorly studied.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab83b614e83c0d564c12ae12a3d52319
https://doi.org/10.1128/jvi.00127-09