Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Matthew D Zimmerman"'
Autor:
Richard C Lavin, Calvin Johnson, Yong-Mo Ahn, Kyle M Kremiller, Matthew Sherwood, Jimmy S Patel, Yan Pan, Riccardo Russo, Nathan J MacGilvary, David Giacalone, Yuzo L Kevorkian, Matthew D Zimmerman, J Fraser Glickman, Joel S Freundlich, Shumin Tan
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001355 (2021)
Sensing and response to environmental cues, such as pH and chloride (Cl-), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compoun
Externí odkaz:
https://doaj.org/article/e8e92b4c6c2a4557821d17bd95672572
Autor:
Yitian Xu, Lihua Wang, Matthew D Zimmerman, Kai-Yuan Chen, Lu Huang, Dah-Jiun Fu, Firat Kaya, Nikolai Rakhilin, Evgeniya V Nazarova, Pengcheng Bu, Veronique Dartois, David G Russell, Xiling Shen
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006974 (2018)
Mycobacterium tuberculosis (Mtb) remains a grave threat to world health with emerging drug resistant strains. One prominent feature of Mtb infection is the extensive reprogramming of host tissue at the site of infection. Here we report that inhibitio
Externí odkaz:
https://doaj.org/article/27f94f175af94503a0107147390202b8
Autor:
Nadine Alvarez, Gregory C. Adam, John A. Howe, Vijeta Sharma, Matthew D. Zimmerman, Enriko Dolgov, Risha Rasheed, Fatima Nizar, Khushboo Sahay, Andrew M. Nelson, Steven Park, Xiaoyan Zhou, Christine Burlein, John F. Fay, Daniel V. Iwamoto, Carolyn M. Bahnck-Teets, Krista L. Getty, Shih Lin Goh, Imad Salhab, Keith Smith, Christopher W. Boyce, Tamara D. Cabalu, Nicholas Murgolo, Nicholas G. Fox, Todd W. Mayhood, Valerie W. Shurtleff, Mark E. Layton, Craig A. Parish, John A. McCauley, David B. Olsen, David S. Perlin
Publikováno v:
Viruses, Vol 16, Iss 7, p 1158 (2024)
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to be a global threat due to its ability to evolve and generate new subvariants, leading to new waves of infection. Additionally, other coronaviruses like Middle East respira
Externí odkaz:
https://doaj.org/article/5a441246ad714e97bc953aaa660b6bd5
Autor:
Satish R. Malwal, Ben Mazurek, Jihee Ko, Pujun Xie, Chikako Barnes, Christine Varvitsiotis, Matthew D. Zimmerman, Samir Olatunji, Jaeyong Lee, Min Xie, Jansy Sarathy, Martin Caffrey, Natalie C. J. Strynadka, Véronique Dartois, Thomas Dick, Bom Nae Rin Lee, David G. Russell, Eric Oldfield
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::795aa2e7ce9d04ea62216ba0eca39ed4
https://doi.org/10.1021/acs.jmedchem.3c00398
https://doi.org/10.1021/acs.jmedchem.3c00398
Autor:
Shuqi Li, Nicholas C. Poulton, Jesseon S. Chang, Zachary A. Azadian, Michael A. DeJesus, Nadine Ruecker, Matthew D. Zimmerman, Kathryn A. Eckartt, Barbara Bosch, Curtis A. Engelhart, Daniel F. Sullivan, Martin Gengenbacher, Véronique A. Dartois, Dirk Schnappinger, Jeremy M. Rock
Publikováno v:
Nature Microbiology. 7:766-779
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy is limited by Mtb’s intrinsic drug resistance, as well as its ability to evolve acquired resistance to all antituberculars in clinical use. A deeper un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f52c73c301fb7cfa3028e65af38ad33
https://doi.org/10.1038/s41564-022-01130-y
https://doi.org/10.1038/s41564-022-01130-y
Autor:
Kaj M. Kreutzfeldt, Robert S. Jansen, Travis E. Hartman, Alexandre Gouzy, Ruojun Wang, Inna V. Krieger, Matthew D. Zimmerman, Martin Gengenbacher, Jansy P. Sarathy, Min Xie, Véronique Dartois, James C. Sacchettini, Kyu Y. Rhee, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
Nature Communications, 13, 1, pp. 1-11
Nature Communications, 13, 1-11
Nature Communications, 13, 1-11
The ability of Mycobacterium tuberculosis (Mtb) to resist and tolerate antibiotics complicates the development of improved tuberculosis (TB) chemotherapies. Here we define the Mtb protein CinA as a major determinant of drug tolerance and as a potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf6f78aa983d1920e4867f06ef73a0e
https://hdl.handle.net/2066/249717
https://hdl.handle.net/2066/249717
Autor:
Dereje A. Negatu, Rubén González del Río, Mónica Cacho-Izquierdo, David Barros-Aguirre, Joël Lelievre, Joaquín Rullas, Patricia Casado, Uday S. Ganapathy, Matthew D. Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro . Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6668d4f8f3c6b25dd1c8741fce5cef2b
https://doi.org/10.1128/aac.01459-22
https://doi.org/10.1128/aac.01459-22
Autor:
Nicholas D. Walter, Jackie P. Ernest, Christian Dide-Agossou, Allison A. Bauman, Michelle E. Ramey, Karen Rossmassler, Lisa M. Massoudi, Samantha Pauly, Reem Al Mubarak, Martin I. Voskuil, Firat Kaya, Jansy P. Sarathy, Matthew D. Zimmerman, Véronique Dartois, Brendan K. Podell, Radojka M. Savic, Gregory T. Robertson
Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32c2774e6ba237d4dcbaa51a1145d6af
https://doi.org/10.1101/2023.02.03.527062
https://doi.org/10.1101/2023.02.03.527062
Autor:
Jickky Palmae Sarathy, Matthew D. Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick
Publikováno v:
Antimicrobial agents and chemotherapy. 66(12)
The anti-tuberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target retention. OPC-167832 was bactericidal and did not antagonize activity of clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecac7458e367897b6124c559db4800c
https://pubmed.ncbi.nlm.nih.gov/36350151
https://pubmed.ncbi.nlm.nih.gov/36350151
Autor:
Abdeldjalil Madani, Dereje A. Negatu, Abdellatif El Marrouni, Randy R. Miller, Christopher Boyce, Nicholas Murgolo, Christopher J. Bungard, Matthew D. Zimmerman, Véronique Dartois, Martin Gengenbacher, David B. Olsen, Thomas Dick
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Tricyclic pyrrolopyrimidines (TPPs) are a new class of antibacterials inhibiting the ATPase of DNA gyrase. TPP8, a representative of this class, is active against Mycobacterium abscessus in vitro. Spontaneous TPP8 resistance mutations mapped to the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37177682f6362f871ef2526a318de268
https://doi.org/10.1128/aac.00669-22
https://doi.org/10.1128/aac.00669-22