Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Matthew D Taves"'
Publikováno v:
Frontiers in Endocrinology, Vol 2 (2011)
It is well recognized that steroids are synthesized de novo in the brain (neurosteroids). In addition, steroids circulating in the blood enter the brain. Steroids play numerous roles in the brain, such as influencing neural development, behavior, neu
Externí odkaz:
https://doaj.org/article/da30ddcb0f72426292ef2e7162d18695
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15727 (2010)
The brain and other organs locally synthesize steroids. Local synthesis is suggested when steroid levels are higher in tissue than in the circulation. However, measurement of both circulating and tissue steroid levels are subject to methodological co
Externí odkaz:
https://doaj.org/article/77e2aca061e244caabcd0a31679c42a8
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Externí odkaz:
https://doaj.org/article/897dc6e539b041f2aabb784de1363f33
Autor:
Matthew D. Taves, Shizuka Otsuka, Michaela A. Taylor, Kaitlynn M. Donahue, Thomas J. Meyer, Margaret C. Cam, Jonathan D. Ashwell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their primary source is the adrenals, where they are generated via de novo synthesis from cholesterol. In addition, many tissues have a recycling pathway in which glucocor
Externí odkaz:
https://doaj.org/article/6386e35800ae451e81a0f10f47bdcb0d
Autor:
Matthew D. Taves, Jonathan D. Ashwell
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sex steroid hormones have major effects on the thymus. Age-related increases in androgens and estrogens and pregnancy-induced increases in progestins all cause dramatic thymic atrophy. Atrophy can also be induced by treatment with exogenous sex stero
Externí odkaz:
https://doaj.org/article/e6674321f9454cbb8d82dec28a18a0e0
Autor:
Tamara S. Bodnar, Matthew D. Taves, Katie M. Lavigne, Todd S. Woodward, Kiran K. Soma, Joanne Weinberg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory condition with variable clinical presentation and disease progression. Importantly, animal models of RA are widely used to examine disease pathophysiology/treatments. Here, we exploited kno
Externí odkaz:
https://doaj.org/article/6ac0686352cd43b89510e17870d6db72
Publikováno v:
Cancer Research. 83:5863-5863
Glucocorticoids (GCs) are steroid hormones with potent immunosuppressive properties. GCs are primary produced from cholesterol in the adrenals via the de novo synthetic pathway. In some tissues, however, there is also a recycling pathway in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86689dbd28d09c2f0b9c04490f9b98c
https://doi.org/10.1158/1538-7445.am2023-5863
https://doi.org/10.1158/1538-7445.am2023-5863
Autor:
Brittney Russell, Kelly M. Hrelja, Wendy K. Adams, Fiona D. Zeeb, Matthew D. Taves, Sukhbir Kaur, Kiran K. Soma, Catharine A. Winstanley
Publikováno v:
SSRN Electronic Journal.
Social isolation is an established risk factor for mental illness and impaired immune function. Evidence suggests that neuroinflammatory processes contribute to mental illness, possibly via cytokine-induced modulation of neural activity. We examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff26e7cea093fb4d0158b2bc2a69fbd4
https://doi.org/10.2139/ssrn.4011647
https://doi.org/10.2139/ssrn.4011647
Publikováno v:
J Immunol
Glucocorticoid signaling in thymocytes shapes the T cell antigen receptor (TCR) repertoire by antagonizing thymocyte negative selection. The transcription factors Nur77 and Helios, which are upregulated in TCR-signaled thymocytes, have been implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89003c85e7ab10fa20c4438b4752c6f9
https://doi.org/10.4049/jimmunol.1900559
https://doi.org/10.4049/jimmunol.1900559
Autor:
Matthew D. Taves, Jonathan D. Ashwell
Publikováno v:
Nature reviews. Immunology. 21(4)
Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain organismal homeostasis. Circadian and stress-induced changes in systemic GC levels regulate metabolism, cardiovascular and neural function, reproduction and immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be2c47a17a352b86bcb9c53cf2873ab
https://pubmed.ncbi.nlm.nih.gov/33149283
https://pubmed.ncbi.nlm.nih.gov/33149283