Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Matthew D Selby"'
Autor:
David C Pryde, Lyn H Jones, David P Gervais, David R Stead, David C Blakemore, Matthew D Selby, Alan D Brown, Jotham W Coe, Matthew Badland, David M Beal, Rebecca Glen, Yvonne Wharton, Gavin J Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R Merson, Heather L Davis, Michael J McCluskie
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76557 (2013)
Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab function depends on both the quantity (titer) and the quality (affinity)
Externí odkaz:
https://doaj.org/article/d241124036e24c84ac8c79ff70c995d1
Autor:
Emilio F. Stuart, Nick Clarke, Paul Alan Glossop, Neil Feeder, Strang Ross Sinclair, J. W. Watson, Jane L. Burrows, Amy S. Kenyon, Matthew D. Selby, Michael A. Trevethick, Sheena Patel, Rhys M. Jones, Kim James, Karen N. Wright, Dannielle Frances Roberts, Lyn H. Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5121-5126
A 1,2,4-triazole motif was employed as a bioisostere for the ester commonly used in muscarinic antagonists, and subsequent integrative conjugation to a β2 agonist quinolinone furnished a new class of bifunctional MABAs for the treatment of COPD. Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b09018de8f7e915b91637ee9153193
https://doi.org/10.1016/j.bmcl.2015.10.008
https://doi.org/10.1016/j.bmcl.2015.10.008
Autor:
Daniel J. Asby, Matthew D. Selby, Ali Tavassoli, Bruno Linclau, Leona J. Gross, Florent Peron, Nathan Bartlett
Publikováno v:
Chemistry - A European Journal. 20:3306-3310
Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes that possess a non-chelating α-ether substituent, even if the α-position is a quaternary centre and/or a spiro-epoxide. This reaction was used as a k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6aa94167fc77d36c53fe88afbb1252
https://doi.org/10.1002/chem.201304776
https://doi.org/10.1002/chem.201304776
A second-generation synthesis of (-)-luminacin D based on an early stage introduction of the trisubstituted epoxide group is reported, allowing access to the natural product in an improved yield and a reduced number of steps (5.4%, 17 steps vs 2.6%,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe3cae557dbd4db01e74600759508a1
https://eprints.soton.ac.uk/392805/
https://eprints.soton.ac.uk/392805/
Publikováno v:
Organic Process Research & Development. 16:697-703
The development and implementation of a safe and scalable process for the manufacture of corticosteroid PF-4714224 (1) is described. Initial routes used to synthesise analogues from this series directly from fluocinolone acetonide (2) were unsuitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb68d854c69797caca4c82fa87d14081
https://doi.org/10.1021/op200257g
https://doi.org/10.1021/op200257g
Autor:
David Howard Williams, Nigel Alan Swain, Charlotte Alice Louise Lane, Michael Paradowski, Duncan Hay, Matthew D. Selby, Charles E. Mowbray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1156-1159
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94d2bdbb82b128d16e17b7182c7d376
https://doi.org/10.1016/j.bmcl.2011.11.098
https://doi.org/10.1016/j.bmcl.2011.11.098
Autor:
Victoria E. Albrow, Mireia Fernandez-Ocaña, Lyn H. Jones, Klaus Rumpel, Carla Fernandes, David M. Beal, Matthew D. Selby
Publikováno v:
Med. Chem. Commun.. 3:322-325
Quantitative chemical proteomics enabled affinity-isolation and enrichment of the tyrosine receptor kinase TrkA and protein isolation was competed by the inhibitors purvalanol B and staurosporine in a dose-related manner. These methods will advance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69cbf42985a5b521bab8c904f2c193b
https://doi.org/10.1039/c2md00271j
https://doi.org/10.1039/c2md00271j
Autor:
George M. Burslem, Carla Fernandes, Victoria E. Albrow, Lee R. Roberts, Louisa Hitchen, David M. Beal, Lyn H. Jones, Cris Lapthorn, Matthew D. Selby
Publikováno v:
Org. Biomol. Chem.. 10:548-554
A heterotrifunctional template was developed that utilizes thiol-maleimide and click chemistries (both copper-free and copper-mediated) to effect sequential biomolecule conjugations in a one-pot process. The breadth of compatible substrates was illus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a700e95f5c2c145fc95cf53cae776a6
https://doi.org/10.1039/c1ob06398g
https://doi.org/10.1039/c1ob06398g
Autor:
Romesh R. Subramanian, David J. Lamb, Sterghios Moschos, Houria Mechiche, Bruce M. Taylor, Steve Evans, Chris Lapthorn, Michael Yeadon, Kevin Brady, Luis Perez-Tosar, Marion Jurk, Manfred Frick, Sally A. Fancy, Eugen Uhlmann, David Collins, Ovadia Lazari, Lyn H. Jones, Karen G. Spink, Thomas Dino Rockel, Sarah Kearney, Paul Turnpenny, Martin X. Green, Helen Graves, Joerg Vollmer, Gareth Jones, Markus Weber, Matthew D. Selby, Giuseppe Ciaramella, Diana Gikunju
Publikováno v:
Molecular Therapy
Antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) promise specific correction of disease-causing gene expression. Therapeutic implementation, however, has been forestalled by poor delivery to the appropriate tissue, cell type, and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c106f96927b91f97b0eee5196f9309
Publikováno v:
Future Medicinal Chemistry. 3:1679-1701
The administration of compounds by a dry-powder inhaler presents significant challenges to the development and discovery chemist, owing to the stringent requirements placed upon the physical characteristics of the active pharmaceutical ingredient and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd38e06c247f817054042ed2ce5334e
https://doi.org/10.4155/fmc.11.125
https://doi.org/10.4155/fmc.11.125