Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Matthew D Disney"'
Autor:
Jonathan L Chen, Walter N Moss, Adam Spencer, Peiyuan Zhang, Jessica L Childs-Disney, Matthew D Disney
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219210 (2019)
Tauopathies are neurodegenerative diseases that affect millions of people worldwide including those with Alzheimer's disease. While many efforts have focused on understanding the role of tau protein in neurodegeneration, there has been little done to
Externí odkaz:
https://doaj.org/article/a772d2e432454ac4be8e30b6007186dd
Autor:
Collin A O'Leary, Ryan J Andrews, Van S Tompkins, Jonathan L Chen, Jessica L Childs-Disney, Matthew D Disney, Walter N Moss
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0213758 (2019)
The MYC gene encodes a human transcription factor and proto-oncogene that is dysregulated in over half of all known cancers. To better understand potential post-transcriptional regulatory features affecting MYC expression, we analyzed secondary struc
Externí odkaz:
https://doaj.org/article/c7066325bb254a6e98bffdfaa128829e
Autor:
Yuquan Tong, Patrick R.A. Zanon, Xueyi Yang, Xiaoxuan Su, Jessica L. Childs-Disney, Matthew D. Disney
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103271- (2024)
Summary: Small molecules targeting RNA can be valuable chemical probes and potential therapeutics. The interactions between small molecules, particularly fragments, and RNA, however, can be difficult to detect due to their modest affinities and short
Externí odkaz:
https://doaj.org/article/bf84e12dc49843aab28fe12b74c17a66
Autor:
Rita Sattler, Bryan J. Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J. Barmada, Clive N. Svendsen, Matthew D. Disney, Tania F. Gendron, Philip C. Wong, Martin R. Turner, Adam Boxer, Suma Babu, Michael Benatar, Michael Kurnellas, Jonathan D. Rohrer, Christopher J. Donnelly, Lynette M. Bustos, Kendall Van Keuren-Jensen, Penny A. Dacks, Marwan N. Sabbagh, Attendees of the inaugural C9ORF72 FTD/ALS Summit
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1821-1843 (2023)
Abstract A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS; C9ORF72-FTD/ALS). The goal
Externí odkaz:
https://doaj.org/article/29cedee3ed35403a952639263a5b1ede
Autor:
Yuquan Tong, Yeongju Lee, Xiaohui Liu, Jessica L. Childs-Disney, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius, Herbert Waldmann, Matthew D. Disney
Publikováno v:
Nature. 618:169-179
Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular recognition of RNA structures by small molecules. Here we studied molecular recognition pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ddd01fdc061bbc5774956f8b2b5aaea
https://doi.org/10.1038/s41586-023-06091-8
https://doi.org/10.1038/s41586-023-06091-8
Publikováno v:
Journal of Medicinal Chemistry. 66:6523-6541
Although fragment-based drug discovery (FBDD) has been successfully implemented and well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the challenges associate with the selective targeting of RNA, efforts to integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebb8b3d5360e171e2218f93868e0475
https://doi.org/10.1021/acs.jmedchem.3c00034
https://doi.org/10.1021/acs.jmedchem.3c00034
Autor:
Tiffany W. Todd, Zachary T. McEachin, Jeannie Chew, Alexander R. Burch, Karen Jansen-West, Jimei Tong, Mei Yue, Yuping Song, Monica Castanedes-Casey, Aishe Kurti, Judith H. Dunmore, John D. Fryer, Yong-Jie Zhang, Beatriz San Millan, Susana Teijeira Bautista, Manuel Arias, Dennis Dickson, Tania F. Gendron, María-Jesús Sobrido, Matthew D. Disney, Gary J. Bassell, Wilfried Rossoll, Leonard Petrucelli
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: A G4C2 hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TG3C2 repeat expansion is associated with spino
Externí odkaz:
https://doaj.org/article/a1385bc8f994442d9c1094bb8a16c0d4
Autor:
Quentin M. R. Gibaut, Yoshihiro Akahori, Jessica A. Bush, Amirhossein Taghavi, Toru Tanaka, Haruo Aikawa, Lucas S. Ryan, Brian M. Paegel, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21972-21979
A solid-phase DNA-encoded library (DEL) was studied for binding the RNA repeat expansion r(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d70cedce48e526c9dd48ea07de84a3
https://doi.org/10.1021/jacs.2c08883
https://doi.org/10.1021/jacs.2c08883
Autor:
Samantha M. Meyer, Toru Tanaka, Patrick R. A. Zanon, Jared T. Baisden, Daniel Abegg, Xueyi Yang, Yoshihiro Akahori, Zainab Alshakarchi, Michael D. Cameron, Alexander Adibekian, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21096-21102
Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the screening of a DNA-encoded library (DEL) to identify binders of monomeric RNase L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fd2d6a6853884aaa97d960d447d4ac
https://doi.org/10.1021/jacs.2c07217
https://doi.org/10.1021/jacs.2c07217
Autor:
Jessica L. Childs-Disney, Xueyi Yang, Quentin M. R. Gibaut, Yuquan Tong, Robert T. Batey, Matthew D. Disney
Publikováno v:
Nature Reviews Drug Discovery. 21:736-762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::938dece0be80ea56341e14ccddcdadd7
https://doi.org/10.1038/s41573-022-00521-4
https://doi.org/10.1038/s41573-022-00521-4