Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Matthew D Disney"'
Autor:
Yuquan Tong, Patrick R.A. Zanon, Xueyi Yang, Xiaoxuan Su, Jessica L. Childs-Disney, Matthew D. Disney
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103271- (2024)
Summary: Small molecules targeting RNA can be valuable chemical probes and potential therapeutics. The interactions between small molecules, particularly fragments, and RNA, however, can be difficult to detect due to their modest affinities and short
Externí odkaz:
https://doaj.org/article/bf84e12dc49843aab28fe12b74c17a66
Autor:
Pnina Gottfried Komlosh, Jonathan L. Chen, Jessica Childs-Disney, Matthew D. Disney, Dan Canaani
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Previously, we have identified a novel human metastasis-inducing lncRNA (named SKAI1BC), that suppresses the KAI1/CD82 metastasis-suppressing gene and is upregulated in triple negative breast cancer and melanoma derived cell lines. Modeling
Externí odkaz:
https://doaj.org/article/0468ffd7c3734edf826ecdf9677d735b
Autor:
Rita Sattler, Bryan J. Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J. Barmada, Clive N. Svendsen, Matthew D. Disney, Tania F. Gendron, Philip C. Wong, Martin R. Turner, Adam Boxer, Suma Babu, Michael Benatar, Michael Kurnellas, Jonathan D. Rohrer, Christopher J. Donnelly, Lynette M. Bustos, Kendall Van Keuren-Jensen, Penny A. Dacks, Marwan N. Sabbagh, Attendees of the inaugural C9ORF72 FTD/ALS Summit
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1821-1843 (2023)
Abstract A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS; C9ORF72-FTD/ALS). The goal
Externí odkaz:
https://doaj.org/article/29cedee3ed35403a952639263a5b1ede
Autor:
Hafeez S. Haniff, Yuquan Tong, Xiaohui Liu, Jonathan L. Chen, Blessy M. Suresh, Ryan J. Andrews, Jake M. Peterson, Collin A. O’Leary, Raphael I. Benhamou, Walter N. Moss, Matthew D. Disney
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1713-1721 (2020)
Externí odkaz:
https://doaj.org/article/7d0b00c666094ff5a93e78d8eb1ef1ed
Autor:
Jeannie Chew, Casey Cook, Tania F. Gendron, Karen Jansen-West, Giulia del Rosso, Lillian M. Daughrity, Monica Castanedes-Casey, Aishe Kurti, Jeannette N. Stankowski, Matthew D. Disney, Jeffrey D. Rothstein, Dennis W. Dickson, John D. Fryer, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-15 (2019)
Abstract Background A G4C2 hexanucleotide repeat expansion in the noncoding region of C9orf72 is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). Putative disease mechanisms underlying c9FTD/ALS includ
Externí odkaz:
https://doaj.org/article/3004e4a0bfbf435c8645609120c61a22
Autor:
Yuquan Tong, Yeongju Lee, Xiaohui Liu, Jessica L. Childs-Disney, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius, Herbert Waldmann, Matthew D. Disney
Publikováno v:
Nature. 618:169-179
Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular recognition of RNA structures by small molecules. Here we studied molecular recognition pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ddd01fdc061bbc5774956f8b2b5aaea
https://doi.org/10.1038/s41586-023-06091-8
https://doi.org/10.1038/s41586-023-06091-8
Publikováno v:
Journal of Medicinal Chemistry. 66:6523-6541
Although fragment-based drug discovery (FBDD) has been successfully implemented and well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the challenges associate with the selective targeting of RNA, efforts to integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebb8b3d5360e171e2218f93868e0475
https://doi.org/10.1021/acs.jmedchem.3c00034
https://doi.org/10.1021/acs.jmedchem.3c00034
Autor:
Tiffany W. Todd, Zachary T. McEachin, Jeannie Chew, Alexander R. Burch, Karen Jansen-West, Jimei Tong, Mei Yue, Yuping Song, Monica Castanedes-Casey, Aishe Kurti, Judith H. Dunmore, John D. Fryer, Yong-Jie Zhang, Beatriz San Millan, Susana Teijeira Bautista, Manuel Arias, Dennis Dickson, Tania F. Gendron, María-Jesús Sobrido, Matthew D. Disney, Gary J. Bassell, Wilfried Rossoll, Leonard Petrucelli
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: A G4C2 hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TG3C2 repeat expansion is associated with spino
Externí odkaz:
https://doaj.org/article/a1385bc8f994442d9c1094bb8a16c0d4
Autor:
Quentin M. R. Gibaut, Yoshihiro Akahori, Jessica A. Bush, Amirhossein Taghavi, Toru Tanaka, Haruo Aikawa, Lucas S. Ryan, Brian M. Paegel, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21972-21979
A solid-phase DNA-encoded library (DEL) was studied for binding the RNA repeat expansion r(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d70cedce48e526c9dd48ea07de84a3
https://doi.org/10.1021/jacs.2c08883
https://doi.org/10.1021/jacs.2c08883
Autor:
Samantha M. Meyer, Toru Tanaka, Patrick R. A. Zanon, Jared T. Baisden, Daniel Abegg, Xueyi Yang, Yoshihiro Akahori, Zainab Alshakarchi, Michael D. Cameron, Alexander Adibekian, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 144:21096-21102
Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the screening of a DNA-encoded library (DEL) to identify binders of monomeric RNase L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fd2d6a6853884aaa97d960d447d4ac
https://doi.org/10.1021/jacs.2c07217
https://doi.org/10.1021/jacs.2c07217