Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matthew D Christensen"'
Autor:
Matthew D Christensen, Wen Dun, Penelope A Boyden, Mark E Anderson, Peter J Mohler, Thomas J Hund
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 12, p e1000583 (2009)
Calmodulin kinase II (CaMKII) mediates critical signaling pathways responsible for divergent functions in the heart including calcium cycling, hypertrophy and apoptosis. Dysfunction in the CaMKII signaling pathway occurs in heart disease and is assoc
Externí odkaz:
https://doaj.org/article/0262aead4d844d6b9cfe94d9bc14eefd
Autor:
Thrimoorthy Potta, Eshwaran Narayanan, Kapil Kanagal, Zhuo Zhen, Curt M. Breneman, Matthew D. Christensen, Kaushal Rege
Publikováno v:
ACS Biomaterials Science & Engineering. 5:654-669
Quantitative approaches to structure-property relationships are critical for the accelerated design and discovery of biomaterials in biotechnology and medicine. However, the absence of definitive structures, unlike those available for small molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09b33abcc12bda44554f692c26a8b88
https://doi.org/10.1021/acsbiomaterials.8b00963
https://doi.org/10.1021/acsbiomaterials.8b00963
Autor:
Bhavani Miryala, Kaushal Rege, Subhadeep Dutta, Sudhakar Godeshala, Matthew D. Christensen, Purbasha Nandi, Po-Lin Chiu
Publikováno v:
J Mater Chem B
Simultaneous delivery of small molecules and nucleic acids using a single vehicle can lead to novel combination treatments and multifunctional carriers for a variety of diseases. In this study, we report a novel library of aminoglycoside-derived lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c175b128118560a4fe1c5feb9d0263da
https://pubmed.ncbi.nlm.nih.gov/32830211
https://pubmed.ncbi.nlm.nih.gov/32830211
Autor:
Kaushal Rege, Matthew D. Christensen, Sheba Goklany, Karmella A. Haynes, Seyedehmelika Meraji, René Daer, Sudhakar Godeshala, Rajeshwar Nitiyanandan
Publikováno v:
J Control Release
Effective transgene expression in mammalian cells relies on successful delivery, cytoplasmic trafficking, and nuclear translocation of the delivered vector, but delivery is impeded by several formidable physicochemical barriers on the surface of and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcbb3fb088017fee77dcc52ed71ba1f
https://doi.org/10.1016/j.jconrel.2018.06.030
https://doi.org/10.1016/j.jconrel.2018.06.030
Autor:
Laura Gonzalez-Malerva, Joshua LaBaer, Kaushal Rege, Matthew D. Christensen, Jacob Elmer, Seron Eaton
Publikováno v:
J Control Release
Human cells contain hundreds of kinase enzymes that regulate several cellular processes, which likely include transgene delivery and expression. We identified several kinases that influence gene delivery and/or expression by performing a kinome-level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0f5d07ff73fcec572d65aa8e4503fe
https://doi.org/10.1016/j.jconrel.2015.01.036
https://doi.org/10.1016/j.jconrel.2015.01.036
Publikováno v:
Journal of Controlled Release. 172:246-257
Horizontal gene transfer (HGT) is widespread amongst prokaryotes, but eukaryotes tend to be far less promiscuous with their genetic information. However, several examples of HGT from pathogens into eukaryotic cells have been discovered and mimicked t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4d7ff0e5a76ffb29af01201931c1fd
https://doi.org/10.1016/j.jconrel.2013.08.025
https://doi.org/10.1016/j.jconrel.2013.08.025
Autor:
Colleen C. Mitchell, Roseanne M. Wolf, Thomas J. Hund, Matthew D. Christensen, Peter J. Mohler
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 299:H1505-H1514
Normal cardiac excitability depends on the coordinated activity of specific ion channels and transporters within specialized domains at the plasma membrane and sarcoplasmic reticulum. Ion channel dysfunction due to congenital or acquired defects has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01075dec74d13209d300cc4fdb170188
https://doi.org/10.1152/ajpheart.00503.2010
https://doi.org/10.1152/ajpheart.00503.2010
Autor:
Matthew D. Christensen, Yanqing Tian, Sudhakar Godeshala, Bhavani Miryala, Taraka Sai Pavan Grandhi, Kaushal Rege
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 146
The development of effective drug carriers can lead to improved outcomes in a variety of disease conditions. Aminoglycosides have been used as antibacterial therapeutics, and are attractive as monomers for the development of polymeric materials in va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eeb347ebfa5836348675019227e071
https://pubmed.ncbi.nlm.nih.gov/27472455
https://pubmed.ncbi.nlm.nih.gov/27472455
Autor:
Matthew D. Christensen, Karmella A. Haynes, Jacob Elmer, Jennifer Lehrman, Sutapa Barua, Kaushal Rege
Publikováno v:
Biotechnology and bioengineering. 113(6)
Eukaryotic cells maintain an immense amount of genetic information by tightly wrapping their DNA around positively charged histones. While this strategy allows human cells to maintain more than 25,000 genes, histone binding can also block gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2957d6461ef407112e73c1054ea226
https://pubmed.ncbi.nlm.nih.gov/26614912
https://pubmed.ncbi.nlm.nih.gov/26614912
Autor:
Matthew D. Christensen, Kaushal Rege, Thrimoorthy Potta, Curt M. Breneman, James Ramos, Taraka Sai Pavan Grandhi, Zhuo Zhen
Publikováno v:
Biomaterials. 35(6)
We describe the combinatorial synthesis and cheminformatics modeling of aminoglycoside antibiotics-derived polymers for transgene delivery and expression. Fifty-six polymers were synthesized by polymerizing aminoglycosides with diglycidyl ether cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1891497d6ca62346de3e1ed596193c28
https://pubmed.ncbi.nlm.nih.gov/24331709
https://pubmed.ncbi.nlm.nih.gov/24331709