Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Matthew D Blankschien"'
Autor:
Alasdair J E Gordon, Jennifer A Halliday, Matthew D Blankschien, Philip A Burns, Fumio Yatagai, Christophe Herman
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e44 (2009)
Bistable epigenetic switches are fundamental for cell fate determination in unicellular and multicellular organisms. Regulatory proteins associated with bistable switches are often present in low numbers and subject to molecular noise. It is becoming
Externí odkaz:
https://doaj.org/article/d46e4f5cc77d41b48b58b3cf5af4fa40
Autor:
Matthew D Blankschien, Katarzyna Potrykus, Elicia Grace, Abha Choudhary, Daniel Vinella, Michael Cashel, Christophe Herman
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000345 (2009)
Recent structural and biochemical studies have identified a novel control mechanism of gene expression mediated through the secondary channel of RNA Polymerase (RNAP) during transcription initiation. Specifically, the small nucleotide ppGpp, along wi
Externí odkaz:
https://doaj.org/article/67e14f141c534d08bbef26b375a79e16
Autor:
Richard L. Gourse, Elicia D. Grace, Saumya Gopalkrishnan, Wilma Ross, Christophe Herman, Mary E. Girard, Matthew D. Blankschien
Publikováno v:
Journal of Bacteriology. 197:924-931
Horizontal gene transfer by conjugation plays a major role in bacterial evolution, allowing the acquisition of new traits, such as virulence and resistance to antibacterial agents. With the increased antibiotic resistance in bacterial pathogens, a be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1901e5ae38fc380fa8e5b5d4d24b23
https://doi.org/10.1128/jb.02279-14
https://doi.org/10.1128/jb.02279-14
Autor:
Jacob E. Vick, Alexander Chou, Ramon Gonzalez, Matthew D. Blankschien, James M. Clomburg, Seohyoung Kim
Publikováno v:
Metabolic Engineering. 28:202-212
An engineered reversal of the β-oxidation cycle was exploited to demonstrate its utility for the synthesis of medium chain (6-10-carbons) ω-hydroxyacids and dicarboxylic acids from glycerol as the only carbon source. A redesigned β-oxidation rever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f19b868fb61305291f7b3a4c8f303a
https://doi.org/10.1016/j.ymben.2015.01.007
https://doi.org/10.1016/j.ymben.2015.01.007
Autor:
Ramon Gonzalez, Alexander Chou, Seohyoung Kim, Matthew D. Blankschien, James M. Clomburg, Jacob E. Vick
Publikováno v:
Applied and Environmental Microbiology. 81:1406-1416
We recently used a synthetic/bottom-up approach to establish the identity of the four enzymes composing an engineered functional reversal of the β-oxidation cycle for fuel and chemical production in Escherichia coli (J. M. Clomburg, J. E. Vick, M. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cf062d0708e0f6ad5699de8f96ee58
https://doi.org/10.1128/aem.03521-14
https://doi.org/10.1128/aem.03521-14
Autor:
Jacob E. Vick, James M. Clomburg, María Rodríguez-Moyá, Matthew D. Blankschien, Ramon Gonzalez
Publikováno v:
ACS Synthetic Biology. 1:541-554
While we have recently constructed a functional reversal of the β-oxidation cycle as a platform for the production of fuels and chemicals by engineering global regulators and eliminating native fermentative pathways, the system-level approach used m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592a0e6c2772e7281446352260f0ebce
https://doi.org/10.1021/sb3000782
https://doi.org/10.1021/sb3000782
Publikováno v:
DNA Repair. 9:403-413
Maintenance of genomic stability is critical for all cells. Homologous recombination (HR) pathways promote genome stability using evolutionarily conserved proteins such as RecA, SSB, and RecQ, the Escherichia coli homologue of five human proteins at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee100777c412a439ddea63b2d906d820
https://doi.org/10.1016/j.dnarep.2009.12.019
https://doi.org/10.1016/j.dnarep.2009.12.019
Autor:
Richard L. Gourse, Christophe Herman, Jeong-Hyun Lee, Wilma Ross, Elicia D. Grace, Matthew D. Blankschien, Jennifer A. Halliday, Christopher W. Lennon
Publikováno v:
The EMBO Journal. 28:1720-1731
At specific times during bacterial growth, the transcription factor DksA and the unusual nucleotide regulator ppGpp work synergistically to inhibit some Escherichia coli promoters (e.g. rRNA promoters) and to stimulate others (e.g. promoters for amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17037304e8eb1cbfc154e678ce59b727
https://doi.org/10.1038/emboj.2009.126
https://doi.org/10.1038/emboj.2009.126
Autor:
Daniel B. Magner, James R. Lupski, Jeanine M. Pennington, Jennifer A. Lee, Susan M. Rosenberg, Matthew D. Blankschien
Publikováno v:
Molecular Cell. 26:273-286
The RecQ-helicase family is widespread, highly conserved, and includes human orthologues that suppress genomic instability and cancer. In vivo, some RecQ homologues promote reduction of steady-state levels of bimolecular recombination intermediates (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e65faf1df93263369ce0cd3856314c
https://doi.org/10.1016/j.molcel.2007.03.012
https://doi.org/10.1016/j.molcel.2007.03.012
Publikováno v:
Genes & Development. 20:1776-1789
The heat-shock response (HSR), a universal cellular response to heat, is crucial for cellular adaptation. In Escherichia coli, the HSR is mediated by the alternative σ factor, σ32. To determine its role, we used genome-wide expression analysis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6800c416200c12f7064387d41f48328
https://doi.org/10.1101/gad.1428206
https://doi.org/10.1101/gad.1428206