The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

Autor: Dimitrios Chanouzas, Michael Sagmeister, Lovesh Dyall, Phoebe Sharp, Lucy Powley, Serena Johal, Jessica Bowen, Peter Nightingale, Charles J. Ferro, Matthew D. Morgan, Paul Moss, Lorraine Harper

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)

Abstract Background Cardiovascular disease is a leading cause of death in ANCA-associated vasculitis (AAV). An expansion of CD4+CD28null T cells is seen mainly in cytomegalovirus (CMV)-seropositive individuals and has been linked to increased cardiov

Externí odkaz: https://doaj.org/article/b41be7dea3974d7ca0ac692fada56293

Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study

Autor: Sukhwant Sehmi, Ian Litchfield, Sheila Greenfield, Catherine A Hewitt, Charlotte L. Edwardson, Linda Coughlan, Natalie Ives, Sue Jowett, Sarah Tearne, Nathan P Dawkins, Fiona Cramp, Kate Fletcher, Amanda Daley, Matthew D. Morgan, Shalela Kodabuckus, Lorraine Harper, Dimitrios Chanouzas, Caroline Dean, Hollie K Caulfield

Publikováno v: Rheumatology (Oxford)

Objective Patients with ANCA-associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability of a definitive randomized controlled trial of a behavioural-based physical a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e247609cc0bfc7df4118ffc901c01c
https://doi.org/10.1093/rheumatology/keaa890

The Longitudinal Course of Fatigue in Antineutrophil Cytoplasmic Antibody–associated Vasculitis

Autor: Rachel B Jones, David R W Jayne, Matthew D. Morgan, Lorraine Harper, Dimitrios Chanouzas, Lucy O’Malley, Neil Basu, Katie L Druce

Publikováno v: The Journal of Rheumatology. 47:572-579

Objective.Fatigue is common and burdensome in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). This study aimed to understand how fatigue changes over time following treatment initiation and to determine whether individuals with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23018c5cb2ceda8f018269f3a920f91e
https://doi.org/10.3899/jrheum.190113

Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study

Autor: William F. Pendergraft, Elizabeth Krarup, Wladimir Szpirt, Lorraine Harper, Juliana Draibe, Jessica Anne Dale, Susan L. Hogan, Matthew D. Morgan, Alan D. Salama, Julie Anne G. McGregor, Keegan Lee, Martin Egfjord, Neil Basu, Paula Dospinescu, Dimitrios Chanouzas, Caroline J. Poulton, Peter Nightingale

Publikováno v: BMC Nephrology
Chanouzas, D, McGregor, J A G, Nightingale, P, Salama, A D, Szpirt, W M, Basu, N, Morgan, M D, Poulton, C J, Draibe, J B, Krarup, E, Dospinescu, P, Dale, J A, Pendergraft, W F, Lee, K, Egfjord, M, Hogan, S L & Harper, L 2019, ' Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis : a multi-center retrospective cohort study ', BMC Nephrology, vol. 20, 58 . https://doi.org/10.1186/s12882-019-1226-0
BMC Nephrology, Vol 20, Iss 1, Pp 1-8 (2019)

Background Intravenous pulse methylprednisolone (MP) is commonly included in the management of severe ANCA associated vasculitis (AAV) despite limited evidence of benefit. We aimed to evaluate outcomes in patients who had, or had not received MP, alo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41c995373f80e50947aaef212161cfa
https://doi.org/10.1186/s12882-019-1226-0

How does the outcome of research training fellowships funded via the NHS compare with that from competitively funded fellowships from the MRC and other charities: a cross-sectional retrospective survey of trainees undertaking research training in the West Midlands

Autor: Charlotte Maybury, Lorraine Harper, Russell Smith, Matthew D. Morgan

Publikováno v: BMJ Open

ObjectivesThis study aimed to investigate the impact of research training funded via the National Health Service (NHS) on medical trainees compared with traditional clinical research training fellowships (CRTFs).Design, setting and participantsOnline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843fd3b0dae8a92a1f3a11c517aaefd4
https://pubmed.ncbi.nlm.nih.gov/29362273