Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Matthew D, Marsden"'
Publikováno v:
Viruses, Vol 16, Iss 7, p 1163 (2024)
The latent reservoir remains a major roadblock to curing human immunodeficiency virus (HIV) infection. Currently available antiretroviral therapy (ART) can suppress active HIV replication, reduce viral loads to undetectable levels, and halt disease p
Externí odkaz:
https://doaj.org/article/b08608cf97be4bedb654f14ec4e9061b
Autor:
Jocelyn T. Kim, Tian-Hao Zhang, Camille Carmona, Bryanna Lee, Christopher S. Seet, Matthew Kostelny, Nisarg Shah, Hongying Chen, Kylie Farrell, Mohamed S. A. Soliman, Melanie Dimapasoc, Michelle Sinani, Kenia Yazmin Reyna Blanco, David Bojorquez, Hong Jiang, Yuan Shi, Yushen Du, Natalia L. Komarova, Dominik Wodarz, Paul A. Wender, Matthew D. Marsden, Ren Sun, Jerome A. Zack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, Kim et al. describe a new kick and kill strategy utilizing a single administration of a protein kinase C modulator and latency reversing agent in combination with injections of allogeneic peripheral blood natural killer cells diminishes the HIV
Externí odkaz:
https://doaj.org/article/7b9b98b368d54eccabea67b1cb3df389
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Approximately 38 million people were living with human immunodeficiency virus (HIV) in 2020 and 53% of those infected were female. A variety of virological and immunological sex-associated differences (sexual dimorphism) in HIV infection have been re
Externí odkaz:
https://doaj.org/article/295fd5ec318a4046a98fb1ee231d406e
Autor:
Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cel
Externí odkaz:
https://doaj.org/article/ebe37911de374c93a36c1ee604f378a0
Autor:
Matthew D. Marsden
Publikováno v:
Retrovirology, Vol 17, Iss 1, Pp 1-6 (2020)
Abstract Significant advances in the treatment of HIV infection have been made in the last three decades. Antiretroviral therapy (ART) is now potent enough to prevent virus replication and stop disease progression. However, ART alone does not cure th
Externí odkaz:
https://doaj.org/article/2dc8b57a269b452f9b07e9da4cae70af
Autor:
Jose A. Moran, Alok Ranjan, Rami Hourani, Jocelyn T. Kim, Paul A. Wender, Jerome A. Zack, Matthew D. Marsden
Publikováno v:
Virology. 581:8-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4137b4194e997f92cef3e1690347f184
https://doi.org/10.1016/j.virol.2023.02.009
https://doi.org/10.1016/j.virol.2023.02.009
Autor:
Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 3, Pp 100037- (2020)
Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells. We have previously reported that induc
Externí odkaz:
https://doaj.org/article/844b2284d4654ae7b526e217e79fb151
Autor:
Jose A. Moran, Matthew D. Marsden
Publikováno v:
Cell Host & Microbe. 31:571-573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a2a3e4f0f8c3f19fc29fc8801f1b87
https://doi.org/10.1016/j.chom.2023.03.012
https://doi.org/10.1016/j.chom.2023.03.012
Autor:
Matthew D Marsden, Brian A Loy, Xiaomeng Wu, Christina M Ramirez, Adam J Schrier, Danielle Murray, Akira Shimizu, Steven M Ryckbosch, Katherine E Near, Tae-Wook Chun, Paul A Wender, Jerome A Zack
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006575 (2017)
The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads to persistence and episodic resupply of the virus in patients treated with antiretroviral therapy (ART), thereby preventing eradication of the disease. Pr
Externí odkaz:
https://doaj.org/article/c998df027e184fcbbd41169f173cc22d