Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Matthew Creegan"'
Autor:
Andrey Tokarev, Kawthar Machmach, Matthew Creegan, Dohoon Kim, Michael A. Eller, Diane L. Bolton
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT HIV-1 cure strategies aiming to eliminate persistent infected cell reservoirs are hampered by a poor understanding of cells harboring viral DNA in vivo. We describe a novel method to identify, enumerate, and characterize in detail individual
Externí odkaz:
https://doaj.org/article/217c036c224344a9b088c0a32618b858
Autor:
Kerri G. Lal, Dohoon Kim, Margaret C. Costanzo, Matthew Creegan, Edwin Leeansyah, Joana Dias, Dominic Paquin-Proulx, Leigh Anne Eller, Alexandra Schuetz, Yuwadee Phuang-ngern, Shelly J. Krebs, Bonnie M. Slike, Hannah Kibuuka, Lucas Maganga, Sorachai Nitayaphan, Josphat Kosgei, Carlo Sacdalan, Jintanat Ananworanich, Diane L. Bolton, Nelson L. Michael, Barbara L. Shacklett, Merlin L. Robb, Michael A. Eller, Johan K. Sandberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Here, using longitudinal pre- and post-infection samples from the RV217 Early Capture HIV Cohort Study, the authors show that mucosa-associated invariant T (MAIT) cells become activated and expand during the early acute phase of HIV infection, with s
Externí odkaz:
https://doaj.org/article/bd358f6fc61c41148394e312726032c9
Autor:
Vishakha Sharma, Matthew Creegan, Andrey Tokarev, Denise Hsu, Bonnie M Slike, Carlo Sacdalan, Phillip Chan, Serena Spudich, Jintanat Ananworanich, Michael A Eller, Shelly J Krebs, Sandhya Vasan, Diane L Bolton, RV254/SEARCH010 and RV304/SEARCH013 Study Teams
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010105 (2021)
HIV-1 replication within the central nervous system (CNS) impairs neurocognitive function and has the potential to establish persistent, compartmentalized viral reservoirs. The origins of HIV-1 detected in the CNS compartment are unknown, including w
Externí odkaz:
https://doaj.org/article/16b8b6926f974bd59d2620d0c8b1fc0a
Autor:
Dominic Paquin-Proulx, Bronwyn M. Gunn, Aljawharah Alrubayyi, Danielle V. Clark, Matthew Creegan, Dohoon Kim, Hannah Kibuuka, Monica Millard, Salim Wakabi, Leigh Anne Eller, Nelson L. Michael, Randal J. Schoepp, Matthew J. Hepburn, Lisa E. Hensley, Merlin L. Robb, Galit Alter, Michael A. Eller
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antibodies that mediate non-neutralizing functions play an important role in the immune response to Ebola virus (EBOV) and are thought to impact disease outcome. EBOV has also been associated with long term sequelae in survivors, however, the extent
Externí odkaz:
https://doaj.org/article/2e611cf7edd8448aaa42d3676f73a588
Autor:
Margaret C. Costanzo, Dohoon Kim, Matthew Creegan, Kerri G. Lal, Julie A. Ake, Jeffrey R. Currier, Hendrik Streeck, Merlin L. Robb, Nelson L. Michael, Diane L. Bolton, Nicholas J. Steers, Michael A. Eller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in
Externí odkaz:
https://doaj.org/article/e4a9908351094565842dd84f98c3598c
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169247 (2017)
Modified Vaccinia virus has been shown to be a safe and immunogenic vector platform for delivery of HIV vaccines. Use of this vector is of particular importance to the military, with the implementation of a large scale smallpox vaccination campaign i
Externí odkaz:
https://doaj.org/article/2737d4eb0ee74a4782373be60388a555
Autor:
Andrey Tokarev, Kawthar Machmach, Matthew Creegan, Dohoon Kim, Michael A. Eller, Diane L. Bolton
Publikováno v:
Microbiology Spectrum. 10
Effective combination antiretroviral therapy controls HIV-1 infection but fails to eliminate latent viral reservoirs that give rise to viremia upon treatment interruption. Strategies to eradicate latently infected cells require a better understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1756d56ab37d3fc1574533a534dd30af
https://doi.org/10.1128/spectrum.00604-22
https://doi.org/10.1128/spectrum.00604-22
Autor:
Michael A. Eller, Search Study Groups, Vishakha Sharma, Maria Montero, Diane L. Bolton, Thep Chalermchai, Pasiri Sithinamsuwan, Bonnie M. Slike, Victor Valcour, Shelly J. Krebs, Silvia Ratto-Kim, Christopher Bryant, Matthew Creegan
Publikováno v:
AIDS. 34:1289-1301
OBJECTIVE Mechanisms underlying immune activation and HIV-associated neurocognitive disorders (HAND) in untreated chronic infection remain unclear. The objective of this study was to identify phenotypic and transcriptional changes in blood monocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b161cc066a081714bad6f92297ba86d0
https://doi.org/10.1097/qad.0000000000002537
https://doi.org/10.1097/qad.0000000000002537
Autor:
Kerri G. Lal, Rungsun Rerknimitr, Leigh Anne Eller, Aljawharah Alrubayyi, Dominic Paquin-Proulx, Eugene Kroon, Shelly J. Krebs, Andrey Tokarev, Diane L. Bolton, Suchada Suhkumvittaya, Suteeraporn Pinyakorn, Nelson L. Michael, Merlin L. Robb, Bonnie M. Slike, Johan K. Sandberg, Mark de Souza, Matthew Creegan, Alexandra Schuetz, Nicolas Chomont, Nittaya Phanuphak, Nitiya Chomchey, Yuwadee Phuang-Ngern, Michael A. Eller, Jintanat Ananworanich, study groups, Chayada Sajjaweerawan, Amélie Pagliuzza
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 118(46):e2104721118. National Academy of Sciences
Acute HIV-1 infection (AHI) results in the widespread depletion of CD4+ T cells in peripheral blood and gut mucosal tissue. However, the impact on the predominantly CD4+ immunoregulatory invariant natural killer T (iNKT) cells during AHI remains unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e229f3fff588719c48064e2160b7cc97
https://doi.org/10.1073/pnas.2104721118
https://doi.org/10.1073/pnas.2104721118
Autor:
Dominic, Paquin-Proulx, Kerri G, Lal, Yuwadee, Phuang-Ngern, Matthew, Creegan, Andrey, Tokarev, Suchada, Suhkumvittaya, Aljawharah, Alrubayyi, Eugène, Kroon, Suteeraporn, Pinyakorn, Bonnie M, Slike, Diane L, Bolton, Shelly J, Krebs, Leigh Anne, Eller, Chayada, Sajjaweerawan, Amélie, Pagliuzza, Nicolas, Chomont, Rungsun, Rerknimitr, Nitiya, Chomchey, Nittaya, Phanuphak, Mark S, de Souza, Nelson L, Michael, Merlin L, Robb, Jintanat, Ananworanich, Johan K, Sandberg, Michael A, Eller, Alexandra, Schuetz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Evidence suggests that HIV-1 disease progression is determined in the early stages of infection. Here, preinfection invariant natural killer T (iNKT) cell levels were predictive of the peak viral load during acute HIV-1 infection (AHI).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::527aab0e156c96177b08874656a772c1
https://pubmed.ncbi.nlm.nih.gov/34753817
https://pubmed.ncbi.nlm.nih.gov/34753817