Novel viral splicing events and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts.

Autor: Alexander M Price, Robert T Steinbock, Richard Lauman, Matthew Charman, Katharina E Hayer, Namrata Kumar, Edwin Halko, Krystal K Lum, Monica Wei, Angus C Wilson, Benjamin A Garcia, Daniel P Depledge, Matthew D Weitzman

Publikováno v: PLoS Pathogens, Vol 18, Iss 9, p e1010797 (2022)

Adenovirus is a common human pathogen that relies on host cell processes for transcription and processing of viral RNA and protein production. Although adenoviral promoters, splice junctions, and polyadenylation sites have been characterized using lo

Externí odkaz: https://doaj.org/article/eaab36792be84a51a07f2ccdca52cc19

Adenovirus Remodeling of the Host Proteome and Host Factors Associated with Viral Genomes

Autor: Joseph M. Dybas, Krystal K. Lum, Katarzyna Kulej, Emigdio D. Reyes, Richard Lauman, Matthew Charman, Caitlin E. Purman, Robert T. Steinbock, Nicholas Grams, Alexander M. Price, Lydia Mendoza, Benjamin A. Garcia, Matthew D. Weitzman

Publikováno v: mSystems, Vol 6, Iss 4 (2021)

ABSTRACT Viral infections are associated with extensive remodeling of the cellular proteome. Viruses encode gene products that manipulate host proteins to redirect cellular processes or subvert antiviral immune responses. Adenovirus (AdV) encodes pro

Externí odkaz: https://doaj.org/article/8263a46ee7ba41df86e9a00e6d03a9fc

A viral biomolecular condensate coordinates assembly of progeny particles

Autor: Matthew Charman, Nicholas Grams, Namrata Kumar, Edwin Halko, Joseph M. Dybas, Amber Abbott, Krystal K. Lum, Daniel Blumenthal, Elene Tsopurashvili, Matthew D. Weitzman

Publikováno v: Nature. 616:332-338

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a680adf06227a1159da6a6a0066cb5e5
https://doi.org/10.1038/s41586-023-05887-y

Constitutive TRIM22 expression in the respiratory airway confers a pre-existing defence against influenza A virus infection

Autor: Matthew Charman, Steven McFarlane, Joanna K. Wojtus, Elizabeth Sloan, Rebecca Dewar, Gail Leeming, Mohammed Al-Saadi, Laura Hunter, Miles W. Carroll, James P. Stewart, Paul Digard, Edward Hutchinson, Chris Boutell

Publikováno v: Charman, M, Mcfarlane, S T, Wojtus, J K, Sloan, E, Digard, P, Leeming, G H, Al-Saadi, M, Hunter, L, Carroll, M W, Stewart, J P, Digard, P, Hutchinson, E & Boutell, C 2021, ' Constitutive TRIM22 expression in the respiratory airway confers a pre-existing defence against influenza A virus infection ', Frontiers in Cellular and Infection Microbiology . https://doi.org/10.3389/fcimb.2021.689707
Frontiers in Cellular and Infection Microbiology
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

The induction of antiviral effector proteins as part of a homeostatically controlled innate immune response to infection plays a critical role in limiting the propagation and transmission of respiratory pathogens. However, the prolonged induction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05edeb993e07d9fd1fe1f587ecc04cde
https://hdl.handle.net/20.500.11820/84088112-0571-45d5-b8e7-a823b3625c24

Viral-mediated ubiquitination impacts interactions of host proteins with viral RNA and promotes viral RNA processing

Autor: Joseph M Dybas, Alexander M. Price, Christin Herrmann, Caitlin E. Purman, Richard Lauman, Matthew Charman, Katharina E. Hayer, Matthew D. Weitzman, Benjamin A. Garcia, Jennifer C. Liddle, Eui Tae Kim

Viruses promote infection by hijacking host ubiquitin machinery to counteract or redirect cellular processes. Adenovirus encodes two early proteins, E1B55K and E4orf6, that together co-opt a cellular ubiquitin ligase complex to overcome host defenses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0046afa96efa6c6057639e4104898db9
https://doi.org/10.1101/2020.06.05.136671