Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Matthew C. Stubbs"'
Autor:
Lucia Mazzacurati, Robert J. Collins, Garima Pandey, Que T. Lambert-Showers, Narmin E. Amin, Ling Zhang, Matthew C. Stubbs, Pearlie K. Epling-Burnette, Holly K. Koblish, Gary W. Reuther
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3503-3514 (2019)
Abstract: Aberrant JAK2 tyrosine kinase signaling drives the development of Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. However, JAK2 kinas
Externí odkaz:
https://doaj.org/article/587c347d89224f06a5f079374062a7ed
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a567f6f5f98a0e2722cba1117219dcd
https://doi.org/10.1158/2159-8290.c.6549361.v1
https://doi.org/10.1158/2159-8290.c.6549361.v1
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Supplementary Figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86778ff5c2d7a876a216678ab35f0a37
https://doi.org/10.1158/2159-8290.22540360
https://doi.org/10.1158/2159-8290.22540360
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Hematological comparison of MF patients versus PDXs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ff66c0f13b2518d81ffaaab1ec8881
https://doi.org/10.1158/2159-8290.22540357
https://doi.org/10.1158/2159-8290.22540357
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Exome sequencing results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fee595b4886906d48090b82109c6e2
https://doi.org/10.1158/2159-8290.22540354
https://doi.org/10.1158/2159-8290.22540354
Autor:
Scott A. Armstrong, Andrew L. Kung, James E. Bradner, Andrei V. Krivtsov, Jun Qi, Matthew Witkin, Janna Minehart, Sridhar Vempati, Tina Davis, Megan Bariteau, Wonil Kim, Matthew C. Stubbs
Supplementary Table S1-S3 Legends and Supplementary Figure S1-S6 Legends. Legends for supplementary tables S1-S3 and supplementary figures S1-S6 which support data in the manuscript, but could not be included due to space constraints.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3278aefd41ce661123c8d89f8a1fbe
https://doi.org/10.1158/1078-0432.22457502
https://doi.org/10.1158/1078-0432.22457502
Autor:
Michael R. Savona, Scott W. Hiebert, Jeffrey C. Rathmell, Kelli Boyd, Phillip C.C. Liu, Matthew C. Stubbs, Melissa A. Fischer, Kristy Stengel, Yue Zhao, Londa Fuller, Agnieszka E. Gorska, Maria P. Arrate, Merrida Childress, Susu Zhang, Dalton Greenwood, Haley E. Ramsey
Purpose:The BCL2 inhibitor, venetoclax, has transformed clinical care in acute myeloid leukemia (AML). However, subsets of patients do not respond or eventually acquire resistance. Venetoclax-based regimens can lead to considerable marrow suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5da4279ef51b8c411d63b6344a073d
https://doi.org/10.1158/1078-0432.c.6529859.v1
https://doi.org/10.1158/1078-0432.c.6529859.v1
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Supplemental Tables 1 & 2 Supplemental Figure Legends Supplemental Figures 1 - 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9cd1caeb5c5e06cfd8b05f86b576b1
https://doi.org/10.1158/1078-0432.22475952
https://doi.org/10.1158/1078-0432.22475952
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Purpose:Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67622e0fbfefceb9ea9cf87738b999fe
https://doi.org/10.1158/1078-0432.c.6529230.v1
https://doi.org/10.1158/1078-0432.c.6529230.v1
Autor:
Scott A. Armstrong, Andrew L. Kung, James E. Bradner, Andrei V. Krivtsov, Jun Qi, Matthew Witkin, Janna Minehart, Sridhar Vempati, Tina Davis, Megan Bariteau, Wonil Kim, Matthew C. Stubbs
Purpose: Histone deacetylase inhibitors (HDACi) have recently emerged as efficacious therapies that target epigenetic mechanisms in hematologic malignancies. One such hematologic malignancy, B-cell acute lymphoblastic leukemia (B-ALL), may be highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23835c0d6e053bece84a8c34a9edfe1b
https://doi.org/10.1158/1078-0432.c.6523596
https://doi.org/10.1158/1078-0432.c.6523596