Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Matthew C. Pahl"'
Autor:
Matthew C. Pahl, Lin Liu, James A. Pippin, Yadav Wagley, Keith Boehm, Kurt D. Hankenson, Andrew D. Wells, Wenli Yang, Struan F.A. Grant
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105038- (2024)
Summary: Background: Carpal tunnel syndrome (CTS) is a common disorder caused by compression of the median nerve in the wrist, resulting in pain and numbness throughout the hand and forearm. While multiple behavioural and physiological factors influe
Externí odkaz:
https://doaj.org/article/936e1d8008fc4156b7c5db74b867d0b6
Autor:
Chaojie Yang, Jenna Veenstra, Traci M. Bartz, Matthew C. Pahl, Brian Hallmark, Yii-Der Ida Chen, Jason Westra, Lyn M. Steffen, Christopher D. Brown, David Siscovick, Michael Y. Tsai, Alexis C. Wood, Stephen S. Rich, Caren E. Smith, Timothy D. O’Connor, Dariush Mozaffarian, Struan F. A. Grant, Floyd H. Chilton, Nathan L. Tintle, Rozenn N. Lemaitre, Ani Manichaikul
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented stron
Externí odkaz:
https://doaj.org/article/ddf869699ad642f1a57ef3ec28d71404
Autor:
Matthew C. Pahl, Carole Le Coz, Chun Su, Prabhat Sharma, Rajan M. Thomas, James A. Pippin, Emylette Cruz Cabrera, Matthew E. Johnson, Michelle E. Leonard, Sumei Lu, Alessandra Chesi, Kathleen E. Sullivan, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background SARS-CoV-2 infection results in a broad spectrum of COVID-19 disease, from mild or no symptoms to hospitalization and death. COVID-19 disease severity has been associated with some pre-existing conditions and the magnitude of the
Externí odkaz:
https://doaj.org/article/8df9b6167b7e4c4c861156596c1735c6
Autor:
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, Sumei Lu, Rick Rausch, James A. Pippin, Maria Caterina De Rosa, Alisha Basak, Jonathan P. Bradfield, Reza K. Hammond, Keith Boehm, Robert I. Berkowitz, Chiara Lasconi, Chun Su, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron
Externí odkaz:
https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
Autor:
Diana L. Cousminer, Yadav Wagley, James A. Pippin, Ahmed Elhakeem, Gregory P. Way, Matthew C. Pahl, Shana E. McCormack, Alessandra Chesi, Jonathan A. Mitchell, Joseph M. Kindler, Denis Baird, April Hartley, Laura Howe, Heidi J. Kalkwarf, Joan M. Lappe, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Hakon Hakonarson, Vicente Gilsanz, John A. Shepherd, Sharon E. Oberfield, Casey S. Greene, Andrea Kelly, Deborah A. Lawlor, Benjamin F. Voight, Andrew D. Wells, Babette S. Zemel, Kurt D. Hankenson, Struan F. A. Grant
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes. Here, we capture this dynamic phenotype by m
Externí odkaz:
https://doaj.org/article/165481b925744dddb170926499acd9cc
Autor:
Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su, Reza K. Hammond, James A. Pippin, Natalie A. Terry, Louis R. Ghanem, Rudolph L. Leibel, Andrew D. Wells, Struan F.A. Grant
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 667-682 (2021)
Background & Aims: Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress
Externí odkaz:
https://doaj.org/article/5ea732da22e64125aa7a08b992a12fda
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci
Autor:
Reza K Hammond, Matthew C Pahl, Chun Su, Diana L Cousminer, Michelle E Leonard, Sumei Lu, Claudia A Doege, Yadav Wagley, Kenyaita M Hodge, Chiara Lasconi, Matthew E Johnson, James A Pippin, Kurt D Hankenson, Rudolph L Leibel, Alessandra Chesi, Andrew D Wells, Struan FA Grant
Publikováno v:
eLife, Vol 10 (2021)
To uncover novel significant association signals (p
Externí odkaz:
https://doaj.org/article/b274c0761bcc4c1a8945975510fddef6
Autor:
Rajan M. Thomas, Matthew C. Pahl, Liqing Wang, Struan F. A. Grant, Wayne W. Hancock, Andrew D. Wells
Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a role for Ikaros has not been established. To det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa238fb2735fc4eb4edfe5d0d15fdbee
https://doi.org/10.1101/2023.05.23.541951
https://doi.org/10.1101/2023.05.23.541951
Autor:
Matthew C. Pahl, Prabhat Sharma, Rajan M. Thomas, Zachary Thompson, Zachary Mount, James Pippin, Peter A. Morawski, Chun Su, Daniel J. Campbell, Struan F.A. Grant, Andrew D. Wells
Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with autoimmune disease, but the causal variants and their contribution to immune dysregulation remain largely unknown. We measured the dynamics of chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbcf18b308b077630551e5b5cfaa80a5
https://doi.org/10.1101/2023.04.05.535731
https://doi.org/10.1101/2023.04.05.535731
Autor:
Chhavi Sood, Md Ausrafuggaman Nahid, Kendall R. Branham, Matthew C. Pahl, Susan E. Doyle, Sarah E. Siegrist
Publikováno v:
bioRxiv
SummaryNeuroblasts inDrosophiladivide asymmetrically, sequentially expressing a series of intrinsic factors to generate a diversity of neuron types. These intrinsic factors known as temporal factors dictate timing of neuroblast transitions in respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe9ea50708ec235e3fef9781a535a9e
https://europepmc.org/articles/PMC10081207/
https://europepmc.org/articles/PMC10081207/