Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Matthew C. Lorincz"'
Autor:
Kentaro Mochizuki, Jafar Sharif, Kenjiro Shirane, Kousuke Uranishi, Aaron B. Bogutz, Sanne M. Janssen, Ayumu Suzuki, Akihiko Okuda, Haruhiko Koseki, Matthew C. Lorincz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Germline genes are repressed by DNA methylation and histone marks. Here, the authors show that specific germline genes hypomethylated pre-implantation are enriched for PRC1.6, H2AK119ub1 and H3K9me3, which coordinately repress their expression.
Externí odkaz:
https://doaj.org/article/006b6218cf214219b0b8f0d42574bd86
Autor:
Aaron B. Bogutz, Julie Brind’Amour, Hisato Kobayashi, Kristoffer N. Jensen, Kazuhiko Nakabayashi, Hiroo Imai, Matthew C. Lorincz, Louis Lefebvre
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Although many species-specific imprinted genes have been identified, how the evolutionary switch from biallelic to imprinted expression occurs is still unknown. Here authors find that lineage-specific ERVs active as oocyte promoters can induce de nov
Externí odkaz:
https://doaj.org/article/23eab72a42084803b96998d94acb4a07
Autor:
Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger, Anne C. Ferguson-Smith
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Background KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous retroviruses through sequ
Externí odkaz:
https://doaj.org/article/3be2fb7bcee5404f99a63cecfba56468
Autor:
Julie Brind’Amour, Hisato Kobayashi, Julien Richard Albert, Kenjiro Shirane, Akihiko Sakashita, Asuka Kamio, Aaron Bogutz, Tasuku Koike, Mohammad M. Karimi, Louis Lefebvre, Tomohiro Kono, Matthew C. Lorincz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syn
Externí odkaz:
https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f09
Autor:
Julien Richard Albert, Tasuku Koike, Hamid Younesy, Richard Thompson, Aaron B. Bogutz, Mohammad M. Karimi, Matthew C. Lorincz
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract Background Allele-specific transcriptional regulation, including of imprinted genes, is essential for normal mammalian development. While the regulatory regions controlling imprinted genes are associated with DNA methylation (DNAme) and spec
Externí odkaz:
https://doaj.org/article/f26e4823969c49ed9bdf9abec90c6f27
Autor:
Wan Kin Au Yeung, Julie Brind’Amour, Yu Hatano, Kazuo Yamagata, Robert Feil, Matthew C. Lorincz, Makoto Tachibana, Yoichi Shinkai, Hiroyuki Sasaki
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 282-293.e4 (2019)
Summary: Mammalian histone methyltransferase G9a (also called EHMT2) deposits H3K9me2 on chromatin and is essential for postimplantation development. However, its role in oogenesis and preimplantation development remains poorly understood. We show th
Externí odkaz:
https://doaj.org/article/e80322b9adb744f09afd94c11f84bdf1
Autor:
Rita Rebollo, Mariana Galvão-Ferrarini, Liane Gagnier, Ying Zhang, Ardian Ferraj, Christine R. Beck, Matthew C. Lorincz, Dixie L. Mager
Publikováno v:
Viruses, Vol 12, Iss 7, p 783 (2020)
Insertions of endogenous retroviruses cause a significant fraction of mutations in inbred mice but not all strains are equally susceptible. Notably, most new Intracisternal A particle (IAP) ERV mutagenic insertions have occurred in C3H mice. We show
Externí odkaz:
https://doaj.org/article/83f479e464ab47e6bd4ef3a48ae740b5
Autor:
Akihiko Okuda, Ayumu Suzuki, Kentaro Mochizuki, Kenjiro Shirane, Haruhiko Koseki, Kousuke Uranishi, Aaron B. Bogutz, Jafar Sharif, Matthew C. Lorincz, Sanne M. Janssen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the blastocyst, implicating alternative repressive pathways before implantation. Indeed, in embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfe3e3a5f168ba1ac4cb64125ae8894
https://doaj.org/article/006b6218cf214219b0b8f0d42574bd86
https://doaj.org/article/006b6218cf214219b0b8f0d42574bd86
Autor:
Julie, Brind'Amour, Matthew C, Lorincz
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2529
Chromatin immunoprecipitation (ChIP) enables the study of DNA-protein interactions. When coupled with high-throughput sequencing (ChIP-seq), this method allows the generation of genome-wide profiles of the distribution of specific proteins in a given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83a317e1637570d52e783655c3aabe07
https://pubmed.ncbi.nlm.nih.gov/35733018
https://pubmed.ncbi.nlm.nih.gov/35733018
Autor:
Zhen Cheng Liu, Matthew C. Lorincz, LeAnn J. Howe, Julie Brind’Amour, Anastasia Kuzmin, Kristoffer N. Jensen, Benjamin J. E. Martin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between histone acetylation and transcription is causal or consequential has not been addressed. Using immunoblot and chromatin immunoprecipitation-sequencing in S. c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56654c4ec7183aa1af35a28ab605a52f
https://doaj.org/article/e1ac767224d040cd8a4977701af65c0d
https://doaj.org/article/e1ac767224d040cd8a4977701af65c0d