Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Matthew C. Jarvis"'
Autor:
Daniel J. Salamango, Terumasa Ikeda, Seyed Arad Moghadasi, Jiayi Wang, Jennifer L. McCann, Artur A. Serebrenik, Diako Ebrahimi, Matthew C. Jarvis, William L. Brown, Reuben S. Harris
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1057-1065.e4 (2019)
Summary: HIV-1 Vif hijacks a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes and PP2A phosphatase regulators (PPP2R5A–E). APOBEC3 counteraction is essential for viral pathogenesis. However, Vif also functions through an unkno
Externí odkaz:
https://doaj.org/article/c1e98fbb6c6d4901afc605ca1d57b854
Autor:
Gabriel J. Starrett, Artur A. Serebrenik, Pieter A. Roelofs, Jennifer L. McCann, Brandy Verhalen, Matthew C. Jarvis, Teneale A. Stewart, Emily K. Law, Annabel Krupp, Mengxi Jiang, John W. M. Martens, Ellen Cahir-McFarland, Paul N. Span, Reuben S. Harris
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple can
Externí odkaz:
https://doaj.org/article/3a082cd74ff645c9aabca1b686b2927e
Autor:
Michael A Carpenter, Nuri A Temiz, Mahmoud A Ibrahim, Matthew C Jarvis, Margaret R Brown, Prokopios P Argyris, William L Brown, Gabriel J Starrett, Douglas Yee, Reuben S Harris
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011043 (2023)
A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by cellular APOBEC3 enzymes, which results in signature C-to-T and C-to-G mutations in TCA and TCT motifs. Although multiple enzymes have been implicated, reports co
Externí odkaz:
https://doaj.org/article/7dba9a036fc5426d8eef1ae0a701054d
Autor:
Prokopios P Argyris, Jordan Naumann, Matthew C Jarvis, Peter E Wilkinson, Dan P Ho, Mohammed N Islam, Indraneel Bhattacharyya, Rajaram Gopalakrishnan, Faqian Li, Ioannis G Koutlas, Alessio Giubellino, Reuben S Harris
Publikováno v:
Histopathology. 82:608-621
Primary head/neck mucosal melanomas (MMs) are rare and exhibit aggressive biologic behaviour and elevated mutational loads. The molecular mechanisms responsible for high genomic instability observed in head/neck MMs remain elusive. The DNA cytosine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503cde7a8bd8547a1433aa23128cc066
https://doi.org/10.1111/his.14843
https://doi.org/10.1111/his.14843
Autor:
Pieter A Roelofs, Chai Yeen Goh, Boon Haow Chua, Matthew C Jarvis, Teneale A Stewart, Jennifer L McCann, Rebecca M McDougle, Michael A Carpenter, John WM Martens, Paul N Span, Dennis Kappei, Reuben S Harris
Publikováno v:
eLife, Vol 9 (2020)
APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element medi
Externí odkaz:
https://doaj.org/article/562661be3bbb4115a4d955575847fc12
Autor:
Reuben S. Harris, Scott H. Kaufmann, S. John Weroha, Xiaonan Hou, Yajue Huang, Ann L. Oberg, Ethan P. Heinzen, Matthew J. Maurer, Krista M. Goergen, Sun-Hee Lee, Britt K. Erickson, Rachel I. Vogel, Martina Bazzaro, William L. Brown, Matthew C. Jarvis, Prokopios P. Argyris, Artur A. Serebrenik
Supplementary Methods, Tables, and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015eed66f6c0fd57b50c54ea735d4162
https://doi.org/10.1158/1078-0432.22478213
https://doi.org/10.1158/1078-0432.22478213
Autor:
Reuben S. Harris, Scott H. Kaufmann, S. John Weroha, Xiaonan Hou, Yajue Huang, Ann L. Oberg, Ethan P. Heinzen, Matthew J. Maurer, Krista M. Goergen, Sun-Hee Lee, Britt K. Erickson, Rachel I. Vogel, Martina Bazzaro, William L. Brown, Matthew C. Jarvis, Prokopios P. Argyris, Artur A. Serebrenik
Purpose:Clear cell ovarian carcinoma (CCOC) is an aggressive disease that often demonstrates resistance to standard chemotherapies. Approximately 25% of patients with CCOC show a strong APOBEC mutation signature. Here, we determine which APOBEC3 enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b4224eb970331808821d3b982f03c9
https://doi.org/10.1158/1078-0432.c.6529889.v1
https://doi.org/10.1158/1078-0432.c.6529889.v1
Autor:
Reuben S Harris, Matthew C Jarvis, Michael A Carpenter, Margaret R Brown, Prokopios P Argyris, William Brown, Douglas Yee
Publikováno v:
Cancer Research. 82:P5-12
Background: Mutations drive the initiation and progression of cancer. A leading druggable source of mutation in cancer is enzymatic deamination of single-stranded DNA cytosines by cellular APOBEC3 enzymes. Cytosine-to-uracil deamination can result in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73ca93b65b03a260b39bd20c67643882
https://doi.org/10.1158/1538-7445.sabcs21-p5-12-01
https://doi.org/10.1158/1538-7445.sabcs21-p5-12-01
Autor:
Sarah Grasedieck, Afsaneh Panahi, Matthew C. Jarvis, Faezeh Borzooee, Reuben S. Harris, Mani Larijani, Hervé Avet-Loiseau, Mehmet Samur, Nikhil Munshi, Kevin Song, Arefeh Rouhi, Florian Kuchenbauer
Background: Recent insights into the pathogenesis of multiple myeloma (MM) have highlighted inflammation and genome editing, e.g. by APOBEC enzymes, as major drivers of disease onset and progression. We hypothesized that inclusion of molecular featur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f37948463e8a67b7dbb561ff5cd4d1ab
https://doi.org/10.21203/rs.3.rs-2184702/v1
https://doi.org/10.21203/rs.3.rs-2184702/v1
Autor:
Matthew C. Jarvis, Michael A. Carpenter, Nuri A. Temiz, Margaret R. Brown, Kyle A. Richards, Prokopios P. Argyris, William L. Brown, Douglas Yee, Reuben S. Harris
A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by cellular APOBEC3 enzymes, which results in C-to-T and C-to-G mutations in TCA and TCT motifs. Although multiple enzymes have been implicated, reports conflict and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef90cfa42e22dff02a92a880e59543c7
https://doi.org/10.1101/2022.04.26.489523
https://doi.org/10.1101/2022.04.26.489523