Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Matthew C. J. Wilce"'
Autor:
Shankar Raj Devkota, Pramod Aryal, Rina Pokhrel, Wanting Jiao, Andrew Perry, Santosh Panjikar, Richard J. Payne, Matthew C. J. Wilce, Ram Prasad Bhusal, Martin J. Stone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Chemokines are key regulators of leukocyte trafficking and attractive targets for anti-inflammatory therapy. Evasins are chemokine-binding proteins from tick saliva, whose application as anti-inflammatory therapeutics will require manipulati
Externí odkaz:
https://doaj.org/article/26d075917c864d76b00e85e35012b9b0
Autor:
Tomalika R. Ullah, Katherine R. Balka, Rebecca L. Ambrose, Geneviève Pépin, Matthew C. J. Wilce, Jacqueline A. Wilce, Belinda J. Thomas, Dominic De Nardo, Bryan R. G. Williams, Michael P. Gantier
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in infected and adjacent cells through i
Externí odkaz:
https://doaj.org/article/a0404e892695413e816c5388d17e47d4
Autor:
Natasha P. Sturre, Rhys N. Colson, Neelam Shah, Gabrielle M. Watson, Xue Yang, Matthew C. J. Wilce, John T. Price, Jacqueline A. Wilce
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1145 (2022)
The development of peptide inhibitors against intracellular targets depends upon the dual challenge of achieving a high affinity and specificity for the target and maintaining cellular permeability for biological activity. Previous efforts to develop
Externí odkaz:
https://doaj.org/article/69126f1703be444598e0709ac52cee14
Autor:
Tali Lang, Jacinta P. W. Lee, Kirstin Elgass, Anita A. Pinar, Michelle D. Tate, Elizabeth H. Aitken, Huapeng Fan, Sarah J. Creed, Nadia S. Deen, Daouda A. K. Traore, Ivo Mueller, Danielle Stanisic, Francesca S. Baiwog, Colin Skene, Matthew C. J. Wilce, Ashley Mansell, Eric F. Morand, James Harris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
MIF is a cytokine best known for its modulatory effect on expression of proinflammatory cytokines. Here the authors show that MIF facilitates the NLRP3–vimentin interaction, resulting in Nlrp3 inflammasome activation.
Externí odkaz:
https://doaj.org/article/e3f4f9c8a1b94be9979682bf263d2d83
Autor:
Craig Don Paul, Csaba Kiss, Daouda A. K. Traore, Lan Gong, Matthew C. J. Wilce, Rodney J. Devenish, Andrew Bradbury, Mark Prescott
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/2438269fc4d84118840b21542a5fba60
Autor:
Ram Prasad Bhusal, Pramod Aryal, Shankar Raj Devkota, Rina Pokhrel, Menachem J. Gunzburg, Simon R. Foster, Herman D. Lim, Richard J. Payne, Matthew C. J. Wilce, Martin J. Stone
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(9)
As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects requires structural un
Autor:
Stephen J, Headey, Andrew, Sivakumaran, Vicki, Adams, Dena, Lyras, Julian I, Rood, Martin J, Scanlon, Matthew C J, Wilce
Publikováno v:
Journal of molecular recognition : JMR. 28(5)
The transfer of antibiotic resistance between bacteria is mediated by mobile genetic elements such as plasmids and transposons. TnpX is a member of the large serine recombinase subgroup of site-specific recombinases and is responsible for the excisio
Autor:
Devin W, Close, Craig Don, Paul, Patricia S, Langan, Matthew C J, Wilce, Daouda A K, Traore, Randal, Halfmann, Reginaldo C, Rocha, Geoffery S, Waldo, Riley J, Payne, Joseph B, Rucker, Mark, Prescott, Andrew R M, Bradbury
Publikováno v:
Proteins. 83(7)
In this article, we describe the engineering and X-ray crystal structure of Thermal Green Protein (TGP), an extremely stable, highly soluble, non-aggregating green fluorescent protein. TGP is a soluble variant of the fluorescent protein eCGP123, whic
Autor:
Tatiana P, Soares da Costa, Min Y, Yap, Matthew A, Perugini, John C, Wallace, Andrew D, Abell, Matthew C J, Wilce, Steven W, Polyak, Grant W, Booker
Publikováno v:
Molecular microbiology. 91(1)
Protein biotinylation is catalysed by biotin protein ligase (BPL). The most characterized BPL is from Escherichia coli where it functions as both a biotin ligase and a homodimeric transcriptional repressor. Here we investigated another bifunctional B
Autor:
Menachem J, Gunzburg, Nigus D, Ambaye, Mark P, Del Borgo, Stephanie C, Pero, David N, Krag, Matthew C J, Wilce, Jacqueline A, Wilce
Publikováno v:
Journal of molecular recognition : JMR. 25(1)
Src-homology (SH2) domains are an attractive target for the inhibition of specific signalling pathways but pose the challenge of developing a truly specific inhibitor. The G7-18NATE cyclic peptide is reported to specifically inhibit the growth factor