Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Matthew C. J. Wilce"'
Autor:
Shankar Raj Devkota, Pramod Aryal, Rina Pokhrel, Wanting Jiao, Andrew Perry, Santosh Panjikar, Richard J. Payne, Matthew C. J. Wilce, Ram Prasad Bhusal, Martin J. Stone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Chemokines are key regulators of leukocyte trafficking and attractive targets for anti-inflammatory therapy. Evasins are chemokine-binding proteins from tick saliva, whose application as anti-inflammatory therapeutics will require manipulati
Externí odkaz:
https://doaj.org/article/26d075917c864d76b00e85e35012b9b0
Autor:
Tomalika R. Ullah, Katherine R. Balka, Rebecca L. Ambrose, Geneviève Pépin, Matthew C. J. Wilce, Jacqueline A. Wilce, Belinda J. Thomas, Dominic De Nardo, Bryan R. G. Williams, Michael P. Gantier
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in infected and adjacent cells through i
Externí odkaz:
https://doaj.org/article/a0404e892695413e816c5388d17e47d4
Autor:
Natasha P. Sturre, Rhys N. Colson, Neelam Shah, Gabrielle M. Watson, Xue Yang, Matthew C. J. Wilce, John T. Price, Jacqueline A. Wilce
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1145 (2022)
The development of peptide inhibitors against intracellular targets depends upon the dual challenge of achieving a high affinity and specificity for the target and maintaining cellular permeability for biological activity. Previous efforts to develop
Externí odkaz:
https://doaj.org/article/69126f1703be444598e0709ac52cee14
Autor:
Tali Lang, Jacinta P. W. Lee, Kirstin Elgass, Anita A. Pinar, Michelle D. Tate, Elizabeth H. Aitken, Huapeng Fan, Sarah J. Creed, Nadia S. Deen, Daouda A. K. Traore, Ivo Mueller, Danielle Stanisic, Francesca S. Baiwog, Colin Skene, Matthew C. J. Wilce, Ashley Mansell, Eric F. Morand, James Harris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
MIF is a cytokine best known for its modulatory effect on expression of proinflammatory cytokines. Here the authors show that MIF facilitates the NLRP3–vimentin interaction, resulting in Nlrp3 inflammasome activation.
Externí odkaz:
https://doaj.org/article/e3f4f9c8a1b94be9979682bf263d2d83
Autor:
Ram Prasad Bhusal, Pramod Aryal, Shankar Raj Devkota, Rina Pokhrel, Menachem J. Gunzburg, Simon R. Foster, Herman D. Lim, Richard J. Payne, Matthew C. J. Wilce, Martin J. Stone
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(9)
As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects requires structural un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2454c667f2d1c3b56383b01c9509197a
https://pubmed.ncbi.nlm.nih.gov/35217625
https://pubmed.ncbi.nlm.nih.gov/35217625
Autor:
Craig Don Paul, Daouda A K Traore, Seth Olsen, Rodney J Devenish, Devin W Close, Toby D M Bell, Andrew Bradbury, Matthew C J Wilce, Mark Prescott
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123338 (2015)
Phanta is a reversibly photoswitching chromoprotein (ΦF, 0.003), useful for pcFRET, that was isolated from a mutagenesis screen of the bright green fluorescent eCGP123 (ΦF, 0.8). We have investigated the contribution of substitutions at positions H
Externí odkaz:
https://doaj.org/article/f9860e38d53a43ae9558ab56ffadc089
Autor:
Craig Don Paul, Csaba Kiss, Daouda A K Traore, Lan Gong, Matthew C J Wilce, Rodney J Devenish, Andrew Bradbury, Mark Prescott
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75835 (2013)
We have developed an orange non-fluorescent photochromic protein (quantum yield, 0.003) we call Phanta that is useful as an acceptor in pcFRET applications. Phanta can be repeatedly inter-converted between the two absorbing states by alternate exposu
Externí odkaz:
https://doaj.org/article/6164286db94546849ecbf39c58519ca3
Autor:
Craig Don Paul, Csaba Kiss, Daouda A. K. Traore, Lan Gong, Matthew C. J. Wilce, Rodney J. Devenish, Andrew Bradbury, Mark Prescott
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/2438269fc4d84118840b21542a5fba60
Autor:
Jion M Battad, Daouda A K Traore, Emma Byres, Jamie Rossjohn, Rodney J Devenish, Seth Olsen, Matthew C J Wilce, Mark Prescott
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47331 (2012)
Rtms5 is an deep blue weakly fluorescent GFP-like protein ([Formula: see text], 592 nm; [Formula: see text], 630nm; Φ(F), 0.004) that contains a (66)Gln-Tyr-Gly chromophore tripeptide sequence. We investigated the optical properties and structure of
Externí odkaz:
https://doaj.org/article/d9d5a62b4e20475682b553877f106dd6
Autor:
Stephen J, Headey, Andrew, Sivakumaran, Vicki, Adams, Dena, Lyras, Julian I, Rood, Martin J, Scanlon, Matthew C J, Wilce
Publikováno v:
Journal of molecular recognition : JMR. 28(5)
The transfer of antibiotic resistance between bacteria is mediated by mobile genetic elements such as plasmids and transposons. TnpX is a member of the large serine recombinase subgroup of site-specific recombinases and is responsible for the excisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7de1774809f21009a6fd6c83414532ab
https://pubmed.ncbi.nlm.nih.gov/25720550
https://pubmed.ncbi.nlm.nih.gov/25720550