Výsledky vyhledávání - "Matthew C. Fyfe"

Effect of narrow spectrum versus selective kinase inhibitors on the intestinal proinflammatory immune tesponse in ulcerative colitis

Autor: Thomas T. MacDonald, Claire A. Walshe, Paolo Biancheri, Yemisi Solanke, Eleanor Wood, Matthew C. Fyfe, Martyn R Foster, Adele Rowley, Steve Webber, Sameer Sirohi

Publikováno v: Inflammatory Bowel Diseases

Article first published online 22 April 2016.
Background: Kinases are key mediators of inflammation, highlighting the potential of kinase inhibitors as treatments for inflammatory disorders. Selective kinase inhibitors, however, have proved disa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570ef2437fd45d47ca129b48b4a4cdc0
https://ueaeprints.uea.ac.uk/id/eprint/61985/

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Sa1775 - A Novel Phase 1 Trial Design to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Top1288, a Narrow Spectrum Kinase Inhibitor, Delivered Topically to the Colon via Oral Administration

Autor: Michael D. Taylor, Matthew C. Fyfe, Yemisi Solanke, Martyn Foster, Steve Webber, Adele Rowley, Claire A. Walshe, Ajay Duggal, Simon Travis, Sameer Sirohi

Publikováno v: Gastroenterology. 154:S-390

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7eee3f2e5cfef4b59199539ba19eaf9e
https://doi.org/10.1016/s0016-5085(18)31599-3

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Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders

Autor: Adele Rowley, Katherine M. Oliver, Michael R. Taylor, Martyn R Foster, Suzanne Hagan, Yemisi Solanke, Steve Webber, Michael J. Doughty, Boatemaa Ofori-Frimpong, Matthew C. Fyfe, Sameer Sirohi, Claire A. Walshe

Publikováno v: Investigative Opthalmology & Visual Science. 59:1443

Purpose The purpose of this study is to determine the potential of narrow spectrum kinase inhibitors (NSKIs) to treat inflammatory eye disorders. Methods Human conjunctival epithelial (HCE) cells were retrieved from subjects via impression cytology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19550deee662a31a0736f7e5ee39f8d2
https://doi.org/10.1167/iovs.17-23479

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Tu1880 TOP1210 NSKI Demonstrates Superior Activity and Improved Safety Profile Potential Compared to Corticosteroid and Immunomodulators in Preclinical Models of Colitis

Autor: Adele Rowley, Martyn Foster, Steve Webber, Sameer Sirohi, Claire A. Walshe, Yemisi Solanke, Matthew C. Fyfe

Publikováno v: Gastroenterology. 150:S966-S967

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fd959d2e96f9c9b8c852cd167b6d4f4
https://doi.org/10.1016/s0016-5085(16)33274-7

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Phospho-Flow Cytometry: A Method for Investigating Effects of Narrow Spectrum Kinase Inhibitors on Kinase Phosphorylation as a Clinical Biomarker

Autor: Steve Webber, Claire A. Walshe, Sameer Sirohi, Martyn Foster, Yemisi Solanke, Matthew C. Fyfe

Publikováno v: Gastroenterology. 152:S767

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c90f35adaa27b977add0257f43d0603c
https://doi.org/10.1016/s0016-5085(17)32663-x

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The Pharmacological Profile of TOP1288, a Narrow Spectrum Kinase Inhibitor (NSKI) in Clinical Development as an Anti-Inflammatory Treatment for Ulcerative Colitis

Autor: Adele Rowley, Claire A. Walshe, Steve Webber, Sameer Sirohi, Paolo Biancheri, Thomas T. MacDonald, Yemisi Solanke, Martyn Foster, Matthew C. Fyfe

Publikováno v: Gastroenterology. 152:S766

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b39924ac85d0e327eab2ce1086202cac
https://doi.org/10.1016/s0016-5085(17)32658-6

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The Narrow Spectrum Kinase Inhibitor (NSKI) TOP1288 Demonstrates Potent Anti-Inflammatory Effects in a T Cell Adoptive Transfer Colitis Model Through a Topical Mode of Action

Autor: Adele Rowley, Matthew C. Fyfe, Martyn Foster, Sameer Sirohi, Steve Webber, Claire A. Walshe, Yemisi Solanke

Publikováno v: Gastroenterology. 152:S31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36a4aa843edc23c25ccaa332b8c6723a
https://doi.org/10.1016/s0016-5085(17)30470-5

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Sa1855 Inhibition of Cytokine Release From HT-29 Cells and Ulcerative Colitis Biopsies Is Potentiated by Combination of Selective Kinase Inhibitors and Such Effects Are Mimicked by TOP1210, a Narrow Spectrum Kinase Inhibitor (NSKIi)

Autor: Claire A. Walshe, Adele Rowley, Yemisi Solanke, Eleanor Wood, Steve Webber, Thomas T. MacDonald, Martyn Foster, Matthew C. Fyfe, Paolo Biancheri, Sameer Sirohi

Publikováno v: Gastroenterology. 150:S382

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::986a44c6e87bca6ad303746fe479dbb8
https://doi.org/10.1016/s0016-5085(16)31344-0

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Sa1854 Effects of a Narrow Spectrum Kinase Inhibitor (NSKI) and Selective Kinase Inhibitors on the Intestinal Pro-Inflammatory Immune Response in Ulcerative Colitis

Autor: Adele Rowley, Claire A. Walshe, Yemisi Solanke, Matthew C. Fyfe, Paolo Biancheri, Thomas T. MacDonald, Sameer Sirohi, Martyn Foster, Steve Webber, Eleanor Wood

Publikováno v: Gastroenterology. 150:S382

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::088f36c0785a868a5ae3d5500714e0f7
https://doi.org/10.1016/s0016-5085(16)31343-9

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