Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew C. Cane"'
Autor:
Matthew T. Dickerson, Isabelle Leclerc, Francesca Semplici, Matthew C. Cane, Livia Lopez-Noriega, Gabriela da Silva Xavier, Aida Martinez-Sanchez, Guy A. Rutter, Paul M. W. French, Eleni Georgiadou, Rosario Rizzuto, Timothy J. Pullen, James McGinty, David A. Jacobson, Samuel P. X. Davis, Elizabeth Haythorne
Aims/hypothesis Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca2+ uptake into pancreatic beta cell mitochondria potentiates or antagonises this process is still a matter of debate. Although the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b02eff6ff6f24e5c3032d546cbddff
http://hdl.handle.net/10044/1/79453
http://hdl.handle.net/10044/1/79453
Autor:
Eleni, Georgiadou, Elizabeth, Haythorne, Matthew T, Dickerson, Livia, Lopez-Noriega, Timothy J, Pullen, Gabriela, da Silva Xavier, Samuel P X, Davis, Aida, Martinez-Sanchez, Francesca, Semplici, Rosario, Rizzuto, James A, McGinty, Paul M, French, Matthew C, Cane, David A, Jacobson, Isabelle, Leclerc, Guy A, Rutter
Publikováno v:
Diabetologia
Aims/hypothesis Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca2+ uptake into pancreatic beta cell mitochondria potentiates or antagonises this process is still a matter of debate. Although the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc55b07a235c6a08628a7639febaa143
https://pubmed.ncbi.nlm.nih.gov/32350566
https://pubmed.ncbi.nlm.nih.gov/32350566
Autor:
Paul M. W. French, Guy A. Rutter, Isabelle Leclerc, Francesca Semplici, Eleni Georgiadou, Rosario Rizzuto, David A. Jacobson, Matthew T. Dickerson, Aida Martinez-Sanchez, da Silva Xavier G, Samuel P. X. Davis, Timothy J. Pullen, Elizabeth Haythorne, Matthew C. Cane, James McGinty, Livia Lopez-Noriega
Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca2+uptake into pancreatic β-cell mitochondria potentiates or antagonises this process is still a matter of debate. Although the mitochondrial impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fce62fe69e6140c5bcc4151d69476b
https://doi.org/10.1101/781161
https://doi.org/10.1101/781161
Autor:
Andrei I. Tarasov, Marco Bugliani, Matthew C. Cane, Natalie R. Johnston, Guy A. Rutter, Stephen J. Hughes, Shahab Haghollahi, Silvia Gimeno Brias, Domenico Bosco, Piero Marchetti, David J. Hodson, Ryan K. Mitchell, Paul Johnson
Publikováno v:
Molecular Endocrinology, Vol. 28, No 6 (2014) pp. 860-71
Molecular Endocrinology
Molecular Endocrinology
Incretins such as glucagon-like peptide 1 (GLP-1) are released from the gut and potentiate insulin release in a glucose-dependent manner. Although this action is generally believed to hinge on cAMP and protein kinase A signaling, up-regulated beta ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdeaacc081a4d9dae06a921efeb1ba38
https://doi.org/10.1210/me.2014-1038
https://doi.org/10.1210/me.2014-1038
Autor:
Pauline Chabosseau, Guy A. Rutter, Qifeng Zhang, Matthew C. Cane, Elizabeth Haythorne, Marie-Sophie Nguyen-Tu, Timothy J. Pullen, Aida Martinez-Sanchez, Sophie Sayers
Publikováno v:
Martinez-Sanchez, A, Pullen, T J, Chabosseau, P, Zhang, Q, Haythorne, E, Cane, M C, Nguyen-Tu, M-S, Sayers, S R & Rutter, G A 2016, ' Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion ', Diabetes, vol. 65, no. 5, pp. 1268-82 . https://doi.org/10.2337/db15-1240
Encoding acyl-CoA thioesterase-7 (Acot7) is one of ∼60 genes expressed ubiquitously across tissues but relatively silenced, or disallowed, in pancreatic β-cells. The capacity of ACOT7 to hydrolyze long-chain acyl-CoA esters suggests potential role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068b681fc8d623188e02db3bf12752c7
https://kclpure.kcl.ac.uk/en/publications/0740fa8c-8032-4d75-8dad-7e7af64dde80
https://kclpure.kcl.ac.uk/en/publications/0740fa8c-8032-4d75-8dad-7e7af64dde80
Autor:
Li Wen, Matthew C Cane, Diane Latawiec, Alexei V. Tepikin, Wei Huang, Xiaoying Zhang, Michael Chvanov, Andrea C. Haynes, Ole H. Petersen, Robert Sutton, David Booth, Peter Szatmary, Rajarshi Mukherjee, Yulin Ouyang, David N. Criddle, Victoria Elliott
Publikováno v:
Gut
Objective Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729cfcd38d8d8dd4146b0d4af8dc8805
Publikováno v:
Biochemical and Biophysical Research Communications. 366:288-293
Factor VIII (FVIII) is a key protein in blood coagulation, deficiency or malfunction of which causes Haemophilia A. The sole cure for this condition is intravenous administration of FVIII, whose membrane-bound structure we have studied by Cryo-electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e49174f415d53f3584f213a20d0254
https://doi.org/10.1016/j.bbrc.2007.11.072
https://doi.org/10.1016/j.bbrc.2007.11.072
Autor:
Mark Ibberson Patrick MacDonald, Michele Solimena, Matthew C. Cane, Mario Falchi, Piero Marchetti, Afshan Siddiq, Mark I. McCarthy, Marie-Sophie Nguyen-Tu, Timothy J. Pullen, Matthias Thurner, Pauline Chabosseau, Philippe Froguel, Kyle J. Gaulton, Anke M. Schulte, Priyanka Prabhala, Martijn van de Bunt, Gaelle Carrat, Guy A. Rutter, Anna L. Gloyn, Ming Hu, Jocelyn E. Manning Fox
Publikováno v:
Diabetes & Metabolism. 43:A15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92106db0f65019cf3b1b4079143db9fd
https://doi.org/10.1016/s1262-3636(17)30150-7
https://doi.org/10.1016/s1262-3636(17)30150-7
Autor:
Alexei V. Tepikin, Michael Chvanov, Jane A Armstrong, Yan Li, Matthew C Cane, Robert Sutton, Bhupendra S. Kaphalia, Nicole Cash, Muhammad A. Javed, David Booth, Ole H. Petersen, Mohammed Jaffar, William Greenhalf, Hayley Dingsdale, Wei Huang, David N. Criddle, Rajarshi Mukherjee, Victoria Elliott
Publikováno v:
Gut
Objective: Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters (FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial injury and acute pancreatitis (AP). This study investigated the relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e8c6fe867c099d38ebd12fd36597ab
Publikováno v:
Pancreatology. 12:e2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0177efab2b64b6f7f372e6a42100fe9
https://doi.org/10.1016/j.pan.2012.03.003
https://doi.org/10.1016/j.pan.2012.03.003