Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Matthew C Wright"'
Autor:
Gregory R Young, Tarek M Abdelghany, Alistair C Leitch, Michael P Dunn, Peter G Blain, Clare Lanyon, Matthew C Wright
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229745 (2020)
Ionic liquids are salts used in a variety of industrial processes, and being relatively non-volatile, are proposed as environmentally-friendly replacements for existing volatile liquids. Methylimidazolium ionic liquids resist complete degradation in
Externí odkaz:
https://doaj.org/article/1232e75cc8d44dae952ff1e366b680c6
Autor:
Fouzeyyah Alsaeedi, Rachel Wilson, Charlotte Candlish, Ibrahim Ibrahim, Alistair C Leitch, Tarek M Abdelghany, Colin Wilson, Lyle Armstrong, Matthew C Wright
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218135 (2019)
The rat pancreatic AR42J-B13 (B-13) cell line differentiates into non-replicative hepatocyte-like (B-13/H) cells in response to glucocorticoid. Since this response is dependent on an induction of serine/threonine protein kinase 1 (SGK1), this may sug
Externí odkaz:
https://doaj.org/article/863b72b0d2cf4c7eb6bc3bcb499189ab
Publikováno v:
Journal of Xenobiotics, Vol 14, Iss 3, Pp 907-922 (2024)
Environmental sampling around a landfill site in the UK previously identified the methylimidazolium ionic liquid, 1-octyl-3-methylimidazolium (M8OI), in the soil. More recently, M8OI was shown to be detectable in sera from 5/20 PBC patients and 1/10
Externí odkaz:
https://doaj.org/article/a28192d9c88a4e29b2b3bb1408958473
Autor:
Emma A Fairhall, Michelle A Charles, Philip M E Probert, Karen Wallace, Jennifer Gibb, Chandni Ravindan, Martin Soloman, Matthew C Wright
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150959 (2016)
The proliferative B-13 pancreatic cell line is unique in its ability to generate functional hepatocyte-like (B-13/H) cells in response to exposure to glucocorticoid. In these studies, quantitatively comparable hepatic levels of liver-specific and liv
Externí odkaz:
https://doaj.org/article/ed6f29f4fcd2429e873bb0e917e6cdbe
Autor:
Aimen O Amer, Philip M Probert, Michael Dunn, Margaret Knight, Abigail E Vallance, Paul A Flecknell, Fiona Oakley, Iain Cameron, Steven A White, Peter G Blain, Matthew C Wright
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136173 (2015)
Liver grafts donated after cardiac death are increasingly used to expand the donor pool but are prone to ischaemic-type biliary lesions. The anti-inflammatory effects of the activated pregnane X receptor have previously been shown to be beneficial in
Externí odkaz:
https://doaj.org/article/fd66d4993ea24264ab93994606a508ee
Autor:
Caroline L Wilson, Jelena Mann, Meagan Walsh, Maria J Perrugoria, Fiona Oakley, Matthew C Wright, Chiara Brignole, Daniela Di Paolo, Patrizia Perri, Mirco Ponzoni, Michael Karin, Derek A Mann
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83391 (2014)
Toll-like Receptor 3 (TLR3) is a pathogen pattern recognition receptor that plays a key role in innate immunity. TLR3 signalling has numerous functions in liver, both in health and disease. Here we report that TLR3 is expressed by quiescent hepatic s
Externí odkaz:
https://doaj.org/article/71f7d585cd604254ace52ba7bc53da0f
Autor:
Toni A. Pringle, Erik Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight, Saimir Luli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain human antibody (scAb) that binds specifically to synaptophysin on hepatic myofibroblasts, providing a targeting vector for novel in vivo imaging agents
Externí odkaz:
https://doaj.org/article/249add3f24f543028fdab2584eb87cf2
Autor:
Shireen, Hedya, Alex, Charlton, Alistair C, Leitch, Fahad A, Aljehani, Benjamin, Pinker, Matthew C, Wright, Tarek M, Abdelghany
Publikováno v:
Toxicology in Vitro. 88:105550
The methylimidazolium ionic liquid M8OI was recently found to be present in both the environment and man. In this study, M8OI disposition and toxicity were examined in an established rat progenitor-hepatocyte model. The progenitor B-13 cell was appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce8cdc37f9e992000933f528f24bdf9
https://doi.org/10.1016/j.tiv.2022.105550
https://doi.org/10.1016/j.tiv.2022.105550
Autor:
Tarek M. Abdelghany, Shireen A. Hedya, Carol De Santis, Sahar S. Abd El-Rahman, Jason H. Gill, Noha F. Abdelkader, Matthew C. Wright
Publikováno v:
Ecotoxicology and Environmental Safety. 249:114439
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e97a3bfba98889a4643bcf895e393619
https://doi.org/10.1016/j.ecoenv.2022.114439
https://doi.org/10.1016/j.ecoenv.2022.114439
Autor:
Sabrina Metzger, D Scott Jobe, Shannon H. Romer, Matthew C Wright, Andrew A. Voss, Kristiana Peraza, Mark M. Rich, Brent D. Foy, Robert J. Talmadge, Long-Sheng Song
Publikováno v:
The Journal of General Physiology
This study reveals defects in the transverse tubules of skeletal muscle in the R6/2 model of Huntington’s disease. These results serve as a foundation to simulate electrical activity in skeletal muscle and may help explain the motor deficits in Hun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad59573ebacb4e8fb8f6d97a4f5e3258
https://doi.org/10.1085/jgp.202012637
https://doi.org/10.1085/jgp.202012637