Výsledky vyhledávání - "Matthew C Hearing"

Adolescent morphine exposure impairs cognitive flexibility in female but not male mice

Autor: Aditii Wakhlu, Annabel Engelhardt, Eden M. Anderson, Elaine Grafelman, Abbigail Ouimet, Matthew C. Hearing

Use of prescription opioids continues to rise, especially in adolescent individuals. As adolescence is a critical development window for higher order cognitive functions, thus opioid exposure during this period may have significant long-lasting effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2fef50d7dd7f4cf6672791b7a0c6e87
https://doi.org/10.1101/2023.04.09.536177

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Protracted morphine withdrawal corresponds with sex-specific alterations to motivated behavior and mesoaccumbal subcircuit dopamine cell plasticity

Autor: Devan M. Gomez, Taytum Kahl, Emily Berrington, Matthew C. Hearing

BackgroundOpioid use disorder is associated with enduring psychological withdrawal symptoms believed to contribute to drug abuse. Amongst these are shifts in motivational states, wherein pursuit of drug consumption exceeds that of non-drug rewards, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdcef59edd49ba56490551601b22e7ea
https://doi.org/10.1101/2023.01.29.526129

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Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D1Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin

Autor: Gemma Navarro, William Rea, César Quiroz, Estefanía Moreno, Devan Gomez, Cody J. Wenthur, Vicent Casadó, Lorenzo Leggio, Matthew C. Hearing, Sergi Ferré

Publikováno v: The Journal of Neuroscience. 42:940-953

Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a complex modulatory role that depends o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48f4cc081071177062e841cbf0e11fca
https://doi.org/10.1523/jneurosci.1151-21.2021

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Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D

Autor: Gemma, Navarro, William, Rea, César, Quiroz, Estefanía, Moreno, Devan, Gomez, Cody J, Wenthur, Vicent, Casadó, Lorenzo, Leggio, Matthew C, Hearing, Sergi, Ferré

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2e4da54a2ef158d6666c15ba8895674
https://pubmed.ncbi.nlm.nih.gov/34876469

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Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility

Autor: Eden M Anderson, Steven Loke, Benjamin Wrucke, Annabel Engelhardt, Evan Hess, Kevin Wickman, Matthew C Hearing

BackgroundImbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related disorders and neuropsychiatric disease, including dysregulation of emotion and cognitive functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e32f855b73b4a8f481e0acc40f525027
https://doi.org/10.1101/2020.06.08.139725

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Reversal of morphine-induced cell-type–specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement

Autor: Stephanie R. Ebner, Matthew C. Hearing, Anna E. Ingebretson, Anders J. Asp, Mark J. Thomas, Rachel A. Fischer, Clare E. Schmidt, Jakub Jedynak, Erin B. Larson

Publikováno v: Proceedings of the National Academy of Sciences. 113:757-762

Drug-evoked plasticity at excitatory synapses on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) drives behavioral adaptations in addiction. MSNs expressing dopamine D1 (D1R-MSN) vs. D2 receptors (D2R-MSN) can exert antagonistic effects in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc821f69cbb2de0f3fbbb72728935f2
https://doi.org/10.1073/pnas.1519248113

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Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell

Autor: Anna E. Ingebretson, Matthew C. Hearing, Erin B. Larson, Stephanie R. Ebner, Mark J. Thomas

Publikováno v: Neuroscience. 384

Experience-dependent synaptic plasticity is an important component of both learning and motivational disturbances found in addicted individuals. Here, we investigated the role of cocaine experience-dependent plasticity at excitatory synapses in the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffa5fbd0d7402293e11b54713cd9959
https://pubmed.ncbi.nlm.nih.gov/29885524

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Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons

Autor: Matthew C. Hearing, Anna E. Ingebretson, Rachel A. Fischer, Matthew Kelly, Saïd Kourrich, Jakub Jedynak, Stephanie R. Ebner, Mark J. Thomas

Publikováno v: Neuropsychopharmacology. 41:464-476

Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote drug-seeking and -taking behavior. In rodent addiction models, persistent changes in excitatory glutamatergic neurotransmission in the nucleus accumbens (NAc) appea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab6b97a7d895fbc8c45e547c8c3f980
https://doi.org/10.1038/npp.2015.168

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