Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Matthew C Canver"'
Autor:
Michelle I Lin, Emily N Price, Sonja Boatman, Elliott J Hagedorn, Eirini Trompouki, Sruthi Satishchandran, Charles W Carspecken, Audrey Uong, Anthony DiBiase, Song Yang, Matthew C Canver, Ann Dahlberg, Zhigang Lu, Cheng Cheng Zhang, Stuart H Orkin, Irwin D Bernstein, Jon C Aster, Richard M White, Leonard I Zon
Publikováno v:
eLife, Vol 4 (2015)
Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show that angptl2 overexpression
Externí odkaz:
https://doaj.org/article/d413b0fa911d41d19654119779f21716
Autor:
Vivien A. C. Schoonenberg, Mitchel A. Cole, Qiuming Yao, Claudio Macias-Treviño, Falak Sher, Patrick G. Schupp, Matthew C. Canver, Takahiro Maeda, Luca Pinello, Daniel E. Bauer
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract CRISPR/Cas9 pooled screening permits parallel evaluation of comprehensive guide RNA libraries to systematically perturb protein coding sequences in situ and correlate with functional readouts. For the analysis and visualization of the result
Externí odkaz:
https://doaj.org/article/2479e0160dd1496ebcd0c7520fc62d0b
Autor:
Glenn A. MacLean, Jennifer McEldoon, Jialiang Huang, Jeremy Allred, Matthew C. Canver, Stuart. H. Orkin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Individuals with Trisomy 21 (T21) exhibit numerous hematological abnormalities, including reductions in numbers of circulating B and T lymphocytes. To elucidate molecular mechanisms underlying these phenotypes, we differentiated human isogen
Externí odkaz:
https://doaj.org/article/c790d5a27e354f7cbec740145b8e1ef2
Autor:
Partha Pratim Das, David A. Hendrix, Effie Apostolou, Alice H. Buchner, Matthew C. Canver, Semir Beyaz, Damir Ljuboja, Rachael Kuintzle, Woojin Kim, Rahul Karnik, Zhen Shao, Huafeng Xie, Jian Xu, Alejandro De Los Angeles, Yingying Zhang, Junho Choe, Don Leong Jia Jun, Xiaohua Shen, Richard I. Gregory, George Q. Daley, Alexander Meissner, Manolis Kellis, Konrad Hochedlinger, Jonghwan Kim, Stuart H. Orkin
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1456-1470 (2015)
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from
Externí odkaz:
https://doaj.org/article/1df7a215a1ef40d9b878abbe95055043
Autor:
Yogesh Kumar, Samuel Lessard, Stuart H. Orkin, Stephen J. Turner, Luca Pinello, Matthew C. Canver, Moshe Olshansky, Partha Pratim Das, Michael J. Bullen, Lee H. Wong, Pratibha Tripathi
Publikováno v:
Journal of Biological Chemistry. 295:15797-15809
Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the noncoding genome and control gene expression programs either in cis or in trans. Putative REs have been identified largely based on their regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f564b9d5fd87863b39338c4eccce3b90
https://doi.org/10.1074/jbc.ra120.013772
https://doi.org/10.1074/jbc.ra120.013772
Publikováno v:
Mol Cell
The CRISPR-Cas system offers a programmable platform for eukaryotic genome and epigenome editing. The ability to perform targeted genetic and epigenetic perturbations enables researchers to perform a variety of tasks, ranging from investigating quest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7534404d5151b11eabfb88b724283d0e
https://doi.org/10.1016/j.molcel.2020.06.012
https://doi.org/10.1016/j.molcel.2020.06.012
Autor:
Martin J. Aryee, Sara P. Garcia, Xuran Wang, Keith Joung J, Sowmya Iyer, David R. Liu, Jimin Guo, Hardik Shah, Joy E. Horng, Luca Pinello, Kendell Clement, Kanae E. Sasaki, Karl Petri, Hang Lee, Dewey Kim, Gregory A. Newby, Kiran Musunuru, Matthew C. Canver, Pattanayak
Defining off-target profiles of gene-editing nucleases and CRISPR base editors remains an important challenge for use of these technologies, therapeutic or otherwise. Existing methods can identify off-target sites induced by these gene editors on an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e37db78b6cacf5ed82d029cb9034fd
https://doi.org/10.1101/2021.04.05.438458
https://doi.org/10.1101/2021.04.05.438458
Autor:
Matthew C, Canver, Pratibha, Tripathi, Michael J, Bullen, Moshe, Olshansky, Yogesh, Kumar, Lee H, Wong, Stephen J, Turner, Samuel, Lessard, Luca, Pinello, Stuart H, Orkin, Partha Pratim, Das
Publikováno v:
J Biol Chem
Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the noncoding genome and control gene expression programs either in cis or in trans. Putative REs have been identified largely based on their regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c29e5ca0d0a257fe4c166e5f3c975e28
https://pubmed.ncbi.nlm.nih.gov/32994224
https://pubmed.ncbi.nlm.nih.gov/32994224
Publikováno v:
American Journal of Hematology. 95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb905ea78c069f16a354923af3d8124
https://doi.org/10.1002/ajh.25741
https://doi.org/10.1002/ajh.25741
Publikováno v:
The CRISPR Journal. 1:159-170
The CRISPR-CRISPR-associated (Cas) nuclease system offers the ability to perform unprecedented functional genetic experiments and the promise of therapy for a variety of genetic disorders. The understanding of factors contributing to CRISPR targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc76f511a1883deec40b8398a2996c3
https://doi.org/10.1089/crispr.2017.0016
https://doi.org/10.1089/crispr.2017.0016