Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Matthew C, Stout"'
Autor:
Jonathan R. Brody, Dan A. Dixon, Jordan M. Winter, Paul M. Campbell, Charles J. Yeo, Avinoam Nevler, Cinthya Y. Lowder, Austin Goetz, Eric Londin, Matthew C. Stout, Carmella Romeo, Nicole C. Mambelli-Lisboa, Saswati N. Chand, Ranjan Preet, Mahsa Zarei, Edwin C. Cheung, Shruti Lal
Figure S1: HuR inhibition was successfully achieved by CRISPR/cas9 system. Figure S2: HuR inhibition sensitizes cells to drugs. Figure S3: PDA xenografts with HuR inhibition failed to form tumors. Table S1: Lists the three guide RNAs used to generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de7643e4ff5af091d58ad9d40030fb3
https://doi.org/10.1158/1541-7786.22512819.v1
https://doi.org/10.1158/1541-7786.22512819.v1
Autor:
Jonathan R. Brody, Dan A. Dixon, Jordan M. Winter, Paul M. Campbell, Charles J. Yeo, Avinoam Nevler, Cinthya Y. Lowder, Austin Goetz, Eric Londin, Matthew C. Stout, Carmella Romeo, Nicole C. Mambelli-Lisboa, Saswati N. Chand, Ranjan Preet, Mahsa Zarei, Edwin C. Cheung, Shruti Lal
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893d87f75b99f780caa6bbbab5107d71
https://doi.org/10.1158/1541-7786.c.6540345
https://doi.org/10.1158/1541-7786.c.6540345
Publikováno v:
Biochemical and Biophysical Research Communications. 495:2264-2269
Increased expression of the chemokine CX3CL1 and its sole receptor, CX3CR1 have been correlated with poor pancreatic cancer patient survival and time to recurrence, as well as with pancreatic perineural invasion. We have previously shown that metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49314918cbce1af45ae45d04bb669b97
https://doi.org/10.1016/j.bbrc.2017.12.116
https://doi.org/10.1016/j.bbrc.2017.12.116
Autor:
Matthew C. Stout, Jordan M. Winter, Avinoam Nevler, Ranjan Preet, Eric Londin, Charles J. Yeo, Cinthya Y. Lowder, Shruti Lal, Edwin C. Cheung, Dan A. Dixon, Saswati N. Chand, Austin Goetz, Paul M. Campbell, Carmella Romeo, Jonathan R. Brody, Nicole C. Mambelli-Lisboa, Mahsa Zarei
Publikováno v:
Molecular Cancer Research. 15:696-707
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa7919454ade0955bd5f5ccabe582ad
https://doi.org/10.1158/1541-7786.mcr-16-0361
https://doi.org/10.1158/1541-7786.mcr-16-0361
Autor:
Matthew C. Stout, Paul M Campbell
Publikováno v:
Biochemical pharmacology. 158
RAS is the most commonly mutated driver of tumorigenesis, seen in about 30% of all cancer cases. There is a subset of tumors termed RAS-driven cancers in which RAS mutation or overactivation is evident, including as much as 95% in pancreatic and 50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423f00b075df75c7af064c2a1c68d71d
https://pubmed.ncbi.nlm.nih.gov/30352234
https://pubmed.ncbi.nlm.nih.gov/30352234
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1170
Ras-dependent signaling is an important regulator of cell cycle progression, proliferation, senescence, and apoptosis. Several of the downstream effectors of Ras play dual roles in each of these processes. Under one set of conditions, they promote ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::084d8d5bd6710013f8c4235a91bdd19d
https://pubmed.ncbi.nlm.nih.gov/24906326
https://pubmed.ncbi.nlm.nih.gov/24906326
Publikováno v:
Methods in Molecular Biology ISBN: 9781493908875
Ras-dependent signaling is an important regulator of cell cycle progression, proliferation, senescence, and apoptosis. Several of the downstream effectors of Ras play dual roles in each of these processes. Under one set of conditions, they promote ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3229227810792173462bd2b450ebcc07
https://doi.org/10.1007/978-1-4939-0888-2_21
https://doi.org/10.1007/978-1-4939-0888-2_21
Publikováno v:
Cancer Research. 75:446-446
Despite considerable clinical and basic research efforts, the 5-year survival rate of pancreatic ductal adenocarcinoma (PDAC) remains a dismal 6 percent in the United States. Much of the mortality of the disease is a result, in part, of the unique mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::277077de3a16a9bfdef311aad49f21fd
https://doi.org/10.1158/1538-7445.am2015-446
https://doi.org/10.1158/1538-7445.am2015-446