Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Matthew C, Cook"'
Autor:
Chelisa Cardinez, Yuwei Hao, Kristy Kwong, Ainsley R. Davies, Morgan B. Downes, Nadia A. Roberts, Jason D. Price, Raquel A. Hernandez, Jessica Lovell, Rochna Chand, Zhi-Ping Feng, Anselm Enders, Carola G. Vinuesa, Bahar Miraghazadeh, Matthew C. Cook
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3+ regulatory T cells (Tregs). By contrast, we know very little about the consequences of defects that amplify aspects of Treg function or dif
Externí odkaz:
https://doaj.org/article/db07c536c7a44f49859f6963437bbf1a
Autor:
Jun Yen Ng, Meidelynn Ooi, Samuel K. Bennett, Kirsty Rady, Philip Choi, Wei-I. Lee, Matthew C. Cook, Katrina L. Randall, Nalini K. Pati
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 329-336 (2024)
Introduction: Acquired angioedema due to C1 esterase inhibitor deficiency (C1INH-AAE) is most associated with lymphoproliferative disorders (LPDs), particularly low-grade B-cell subtypes. The condition remains under-recognized with long diagnostic de
Externí odkaz:
https://doaj.org/article/99b838c5418c4e42ae6b95d589eea022
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/5fafc9c828d7413cbdde50269f971ae1
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2023)
More than 400 single gene defects have been identified as inborn errors of immunity, including many arising from genes encoding proteins that affect NF-κB activity. We summarise the skin phenotypes in this subset of disorders and provide an overview
Externí odkaz:
https://doaj.org/article/8e082aedcf8c45a79e87c0c97f14ea0c
Autor:
Yuwei Hao, Matthew C. Cook
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Elucidating links between genotype and phenotype in patients with rare inborn errors of immunity (IEIs) provides insights into mechanisms of immune regulation. In many autosomal dominant IEIs, however, variation in expressivity and penetrance result
Externí odkaz:
https://doaj.org/article/a37858d962fc46eca3248a387e2b1867
Autor:
Matthew A. Field, Gaetan Burgio, Aaron Chuah, Jalila Al Shekaili, Batool Hassan, Nashat Al Sukaiti, Simon J. Foote, Matthew C. Cook, T. Daniel Andrews
Publikováno v:
BMC Genomics, Vol 20, Iss S8, Pp 1-9 (2019)
Abstract Background Short-read resequencing of genomes produces abundant information of the genetic variation of individuals. Due to their numerous nature, these variants are rarely exhaustively validated. Furthermore, low levels of undetected varian
Externí odkaz:
https://doaj.org/article/7149218fe3724c40ba59eaeaf72d6345
Autor:
Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, Carola G. Vinuesa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in th
Externí odkaz:
https://doaj.org/article/78a180011b6f49c096a0159adcd221f4
Autor:
Nashat Al Sukaiti, Khwater Ahmed, Jalila Alshekaili, Mahmood Al Kindi, Matthew C. Cook, Tariq Al Farsi
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
IntroductionSevere combined immunodeficiency (SCID) results from various monogenic defects that impair immune function and brings on early severe and life-threatening infections. The main stay of treatment for SCID is hematopoietic stem cell transpla
Externí odkaz:
https://doaj.org/article/dbdb2c1ea7204af38e313d2958ff53e5
Autor:
Jalila Alshekaili, Rochna Chand, Cindy Eunhee Lee, Susan Corley, Kristy Kwong, Ilenia Papa, David A. Fulcher, Katrina L. Randall, Jennifer W. Leiding, Cindy S. Ma, Marc R. Wilkins, Gulbu Uzel, Chris C. Goodnow, Carola G. Vinuesa, Stuart G. Tangye, Matthew C. Cook
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1hi, but compared to their CD57− PD-1hi counterparts, express little
Externí odkaz:
https://doaj.org/article/e2eb94b50da340409764c3fb20783667
Autor:
Yuwei Hao, Bahar Miraghazadeh, Rochna Chand, Ainsley R. Davies, Chelisa Cardinez, Kristy Kwong, Morgan B. Downes, Rebecca A. Sweet, Pablo F. Cañete, Lloyd J. D’Orsogna, David A. Fulcher, Sharon Choo, Desmond Yip, Geoffrey Peters, Sonia Yip, Matthew J. Witney, Maxim Nekrasov, Zhi-Ping Feng, David C. Tscharke, Carola G. Vinuesa, Matthew C. Cook
As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis of affected patients could yield insights into T-cell differentiation and explain how environmental exposures modify clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03d8ab39340c736b2fb1f6f7c136661
https://www.repository.cam.ac.uk/handle/1810/353613
https://www.repository.cam.ac.uk/handle/1810/353613