Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Matthew B. Wright"'
Autor:
Matthew B. Wright, Javier Varona Santos, Christian Kemmer, Cyrille Maugeais, Jean-Philippe Carralot, Stephan Roever, Judith Molina, G. Michelle Ducasa, Alla Mitrofanova, Alexis Sloan, Anis Ahmad, Christopher Pedigo, Mengyuan Ge, Jeffrey Pressly, Laura Barisoni, Armando Mendez, Jacopo Sgrignani, Andrea Cavalli, Sandra Merscher, Marco Prunotto, Alessia Fornoni
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
This study describes a class of small molecule compounds that promote ABCA1-dependent cholesterol efflux via a non-transcriptional mechanism, the identification of the molecular target by a chemical biology approach, and the potential of these agents
Externí odkaz:
https://doaj.org/article/c5e4a9ac05ca4c609714e39b90c7084e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucia
Externí odkaz:
https://doaj.org/article/b056b20e08564034b50b6ce8b0b6d177
Autor:
Fabiola Paciello, Anna Rita Fetoni, Rolando Rolesi, Matthew B. Wright, Claudio Grassi, Diana Troiani, Gaetano Paludetti
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Recent progress in hearing loss research has provided strong evidence for the imbalance of cellular redox status and inflammation as common predominant mechanisms of damage affecting the organ of Corti including noise induced hearing loss. The discov
Externí odkaz:
https://doaj.org/article/cb1b940559a0459dbe3f65465cb2010e
Autor:
Nathan Huerzeler, Marijana Sekulic-Jablanovic, Matthew B. Wright, Vesna Petkovic, Krystsina Kucharava, Daniel Bodmer
Publikováno v:
Audiology and Neurotology. 24:65-76
Insulin receptors are expressed on nerve cells in the mammalian brain, but little is known about insulin signaling and the expression of the insulin receptor (IR) and glucose transporters in the cochlea. We performed immunohistochemistry and gene/pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4563d978801ba159fa57d0d2f9471bf2
https://doi.org/10.1159/000499561
https://doi.org/10.1159/000499561
Autor:
Vesna Petkovic, Daniel Bodmer, Adrijana Perkovic, Matthew B. Wright, Marijana Sekulic-Jablanovic
Publikováno v:
Journal of Neurochemistry. 139:1113-1123
Hearing impairment is a global health problem with a high socioeconomic impact. Damage to auditory hair cells (HCs) in the inner ear due to aging, disease, trauma, or toxicity, underlies the majority of cases of sensorineural hearing loss. Previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001c080d2a8c96f2ee6fad31a5229974
https://doi.org/10.1111/jnc.13880
https://doi.org/10.1111/jnc.13880
Publikováno v:
Current Drug Metabolism. 7:119-126
Clinical findings indicate that co-administration of the isoxazolyl-penicillin flucloxacillin with cyclosporine may reduce the plasma concentrations of cyclosporine. We have explored in the present study if induction of cytochrome P450 3A4 or P-glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575550f7dfb8864b58e447f6976ee31e
https://doi.org/10.2174/138920006775541534
https://doi.org/10.2174/138920006775541534
Autor:
Christine M. Disteche, Daniel F. Bowen-Pope, Ronald Seifert, Christian Hugo, Matthew B. Wright
Publikováno v:
Journal of Biological Chemistry. 273:23929-23937
The mesangial cell provides structural support to the kidney glomerulus. A polymerase chain reaction-based cDNA display approach identified a novel protein-tyrosine phosphatase, rPTP-GMC1, whose transcript expression is transiently and dramatically u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0299632aff038b4f0b00e5a97456dd76
https://doi.org/10.1074/jbc.273.37.23929
https://doi.org/10.1074/jbc.273.37.23929
Publikováno v:
Journal of Bacteriology. 178:7197-7205
Selection for the ability of Saccharomyces cerevisiae cells to take up histidinol, the biosynthetic precursor to histidine, results in dominant mutations at HOL1. The DNA sequence of HOL1 was determined, and it predicts a 65-kDa protein related to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0173b24f46f70b45fd1b989025b6035e
https://doi.org/10.1128/jb.178.24.7197-7205.1996
https://doi.org/10.1128/jb.178.24.7197-7205.1996
Autor:
Matthew B. Wright
Publikováno v:
Public Choice. 76:103-123
Several empirical studies have suggested that legislators engage in a surprisingly large degree of on-the-job consumption, or ideological behavior. These findings cast doubt on the hypothesis that legislators can be modelled as though they seek to ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d515def2f4c2ae5c7c188f94205e3ead
https://doi.org/10.1007/bf01049345
https://doi.org/10.1007/bf01049345
Autor:
Hassen, Ratni, Matthew B, Wright
Publikováno v:
Current opinion in drug discoverydevelopment. 13(4)
The liver X receptors LXRalpha and LXRbeta regulate the expression of genes promoting cellular cholesterol efflux and the formation of HDL particles, and are atheroprotective. However, LXRalpha and LXRbeta also regulate the expression of genes involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::861311d61d7aefbc69896024357920c4
https://pubmed.ncbi.nlm.nih.gov/20597026
https://pubmed.ncbi.nlm.nih.gov/20597026