Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Matthew B. Tessier"'
Autor:
Matthew B Tessier, Oliver C Grant, Jamie Heimburg-Molinaro, David Smith, Snehal Jadey, Andrew M Gulick, John Glushka, Susan L Deutscher, Kate Rittenhouse-Olson, Robert J Woods
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54874 (2013)
Recombinant antibodies are of profound clinical significance; yet, anti-carbohydrate antibodies are prone to undesirable cross-reactivity with structurally related-glycans. Here we introduce a new technology called Computational Carbohydrate Grafting
Externí odkaz:
https://doaj.org/article/5463c8da170842a0ae77c464d711b708
Combining 3D structure with glycan array data provides insight into the origin of glycan specificity
Autor:
Matthew B. Tessier, Lara K. Mahal, Lawrence Meche, Robert J. Woods, Bethany Lachele Foley, Oliver C. Grant
Publikováno v:
Glycobiology. 26:772-783
Defining how a glycan-binding protein (GBP) specifically selects its cognate glycan from among the ensemble of glycans within the cellular glycome is an area of intense study. Powerful insight into recognition mechanisms can be gained from 3D structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0082f7aa722805569a73d337b199a963
https://doi.org/10.1093/glycob/cww020
https://doi.org/10.1093/glycob/cww020
Publikováno v:
Microfluidics and Nanofluidics
Experiments have consistently revealed the pivotal role of the endothelial glycocalyx layer in vasoregulation and the layer’s contribution to mechanotransduction pathways. However, the exact mechanism by which the glycocalyx mediates fluid shear st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9f061ddcd7fdb4f7f1cda995db2639
https://doi.org/10.1007/s10404-018-2037-5
https://doi.org/10.1007/s10404-018-2037-5
Autor:
Matthew B. Tessier, Spandana Makeneni, Robert J. Woods, Bethany Lachele Foley, Anita K. Nivedha
Publikováno v:
Journal of Computational Chemistry. 35:526-539
Docking algorithms that aim to be applicable to a broad range of ligands suffer reduced accuracy because they are unable to incorporate ligand-specific conformational energies. Here, we develop a set of Carbohydrate Intrinsic (CHI) energy functions t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3248271b216964a492e8e6a9e5c1df
https://doi.org/10.1002/jcc.23517
https://doi.org/10.1002/jcc.23517
Autor:
Robert J. Woods, Benedict M. Sattelle, Bidisha Bose-Basu, Anthony S. Serianni, Andrew Almond, Matthew B. Tessier
Publikováno v:
The Journal of Physical Chemistry B. 116:6380-6386
In the aldohexopyranose idose, the unique presence of flexibility, rendering it challenging to study experimentally and an three axial ring hydroxyl groups causes considerable conformational excellent model for rationalizing the relationship between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72d5e10812b6c3a0e1011c2c9700507
https://doi.org/10.1021/jp303183y
https://doi.org/10.1021/jp303183y
Publikováno v:
Encyclopedia of Computational Chemistry
Carbohydrates present a special set of challenges to the generation of force fields. First, the tertiary structures of monosaccharides are complex merely by virtue of their exceptionally high number of chiral centers. In addition, their electronic ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d42ca630b647c7e803c63a6fa4a910be
https://doi.org/10.1002/wcms.89
https://doi.org/10.1002/wcms.89
Autor:
Robert J. Woods, Matthew B. Tessier
Publikováno v:
Current Opinion in Structural Biology. 20:575-583
Modern computational methods offer the tools to provide insight into the structural and dynamic properties of carbohydrate–protein complexes, beyond that provided by experimental structural biology. Dynamic properties such as the fluctuation of int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41b70d0a9b7b7e75152d4f54f08de9d
https://doi.org/10.1016/j.sbi.2010.07.005
https://doi.org/10.1016/j.sbi.2010.07.005
Publikováno v:
Methods in Molecular Biology ISBN: 9781493923427
A variety of computational techniques may be applied to compute theoretical binding free energies for protein-carbohydrate complexes. Elucidation of the intermolecular interactions, as well as the thermodynamic effects, that contribute to the relativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b1e956e9e65b6ba6d9f8853dfd40e1
https://doi.org/10.1007/978-1-4939-2343-4_26
https://doi.org/10.1007/978-1-4939-2343-4_26
Publikováno v:
Wiley interdisciplinary reviews. Computational molecular science. 2(4)
Carbohydrates present a special set of challenges to the generation of force fields. First, the tertiary structures of monosaccharides are complex merely by virtue of their exceptionally high number of chiral centers. In addition, their electronic ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce937604ed7b60aa89beaf021ccf3f1a
https://pubmed.ncbi.nlm.nih.gov/25530813
https://pubmed.ncbi.nlm.nih.gov/25530813
Publikováno v:
ChemInform. 44
Carbohydrates present a special set of challenges to the generation of force fields. First, the tertiary structures of monosaccharides are complex merely by virtue of their exceptionally high number of chiral centers. In addition, their electronic ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e0483a5083ef84a62946cd73abe745
https://doi.org/10.1002/chin.201310273
https://doi.org/10.1002/chin.201310273