Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Matthew B. Neiditch"'
Autor:
Ishtiyaq Ahmed, Jeanette Hahn, Amy Henrickson, Faisal Tarique Khaja, Borries Demeler, David Dubnau, Matthew B. Neiditch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
ComEA is a DNA-binding protein required for DNA uptake during bacterial transformation. Here, Ahmed et al. determine X-ray crystal structures of ComEA from Gram-positive bacteria, identifying a domain that is absent in Gram-negative bacteria and driv
Externí odkaz:
https://doaj.org/article/f26f79080592443b98b7b3b4ad40850c
Autor:
Andrew Guarnaccia, Wai-Leung Ng, Anjali Steenhaut, Sandra Olenic, Lark J. Perez, Matthew B. Neiditch
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Externí odkaz:
https://doaj.org/article/e1019c3dc0104864b19d0de908c34669
Autor:
Reshma S. Rudraraju, Samer S. Daher, Ricardo Gallardo-Macias, Xin Wang, Matthew B. Neiditch, Joel S. Freundlich
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Recent studies have reported the β-ketoacyl-acyl carrier protein KasA as a druggable target for Mycobacterium tuberculosis. This review summarizes the current status of major classes of KasA inhibitors with an emphasis on significant contributions f
Externí odkaz:
https://doaj.org/article/3dc96799c34046d29477f7a07e79ea77
Autor:
Ana C. Puhl, Thomas R. Lane, Patricia A. Vignaux, Kimberley M. Zorn, Glenn C. Capodagli, Matthew B. Neiditch, Joel S. Freundlich, Sean Ekins
Publikováno v:
ACS Omega, Vol 5, Iss 46, Pp 29935-29942 (2020)
Externí odkaz:
https://doaj.org/article/bff690ac52fc49b0a2d1da9820cf196f
Autor:
Catherine A. Klancher, George Minasov, Ram Podicheti, Douglas B. Rusch, Triana N. Dalia, Karla J. F. Satchell, Matthew B. Neiditch, Ankur B. Dalia
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Regulating gene expression is essential in all domains of life. This process is commonly facilitated by the activity of DNA-binding transcription factors.
Externí odkaz:
https://doaj.org/article/aff55443631b4be5a0512527dddcddaf
Autor:
Felix Adusei-Danso, Faisal Tarique Khaja, Micaela DeSantis, Philip D. Jeffrey, Eugenie Dubnau, Borries Demeler, Matthew B. Neiditch, David Dubnau
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT In Bacillus subtilis, the RicA (YmcA), RicF (YlbF), and RicT (YaaT) proteins accelerate the phosphorylation of the transcription factor Spo0A, contributing to genetic competence, sporulation, and biofilm formation, and are also essential for
Externí odkaz:
https://doaj.org/article/89f19326c9aa4620b076c13dda6e7ddb
Autor:
Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target. The X-ray crystal structure of the KasA-DG167 compl
Externí odkaz:
https://doaj.org/article/8d6c465583e4410c8afdd48c4a9a3287
Autor:
Brian Y. Hsueh, Geoffrey B. Severin, Clinton A. Elg, Evan J. Waldron, Abhiruchi Kant, Alex J. Wessel, John A. Dover, Christopher R. Rhoades, Benjamin J. Ridenhour, Kristin N. Parent, Matthew B. Neiditch, Janani Ravi, Eva M. Top, Christopher M. Waters
Publikováno v:
Nat Microbiol
Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous pandemic V. cholerae strains. Using a co-occurrence analysis of VSP genes in >200,00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaeee08c55d27bb767f0db9a65dc564e
https://europepmc.org/articles/PMC9830645/
https://europepmc.org/articles/PMC9830645/
Autor:
Matthew B. Neiditch, Patricia A Vignaux, Kimberley M. Zorn, Thomas J. Lane, Sean Ekins, Ana C. Puhl, Joel S. Freundlich, Glenn C. Capodagli
Publikováno v:
ACS Omega, Vol 5, Iss 46, Pp 29935-29942 (2020)
Tuberculosis is caused by Mycobacterium tuberculosis (Mtb) and is a deadly disease resulting in the deaths of approximately 1.5 million people with 10 million infections reported in 2018. Recently, a key condensation step in the synthesis of mycolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5c9da0e1fc338c1952ba219170536e
https://doaj.org/article/bff690ac52fc49b0a2d1da9820cf196f
https://doaj.org/article/bff690ac52fc49b0a2d1da9820cf196f
Autor:
Catherine A. Klancher, Ram Podicheti, Ankur B. Dalia, Matthew B. Neiditch, Triana N. Dalia, George Minasov, Douglas B. Rusch, Karla J. F. Satchell
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
mBio
mBio
Regulating gene expression is essential in all domains of life. This process is commonly facilitated by the activity of DNA-binding transcription factors.
Sequence-specific DNA-binding domains (DBDs) are conserved in all domains of life. These p
Sequence-specific DNA-binding domains (DBDs) are conserved in all domains of life. These p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe46eab544dd8800c32d74a2de7eecf
https://doi.org/10.1101/2020.11.18.389122
https://doi.org/10.1101/2020.11.18.389122