Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Matthew B. Maier"'
Autor:
Kevin G. Peters, Conrad Diven, Artem G. Evdokimov, Brian W. Howard, Brooke Cox, Vinit Rastogi, Chuiying Li, Frank Genbauffe, R.L. Walter, Ryan Andrews, Randy T. Bechard, Matthew Pokross, Marlene Mekel, Matthew B. Maier, Jeffrey Lyle Gray
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 62:1435-1445
Protein tyrosine phosphatases (PTPs) play roles in many biological processes and are considered to be important targets for drug discovery. As inhibitor development has proven challenging, crystal structure-based design will be very helpful to advanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f0e3b9f29b2f48701cdd0c80652540
https://doi.org/10.1107/s0907444906037784
https://doi.org/10.1107/s0907444906037784
Autor:
Neil T. Fairweather, Bhavani Kasibhatla, Gina S. Gerwe, George E. Stake, Artem G. Evdokimov, Brian W. Howard, Jeffrey Lyle Gray, Matthew Pokross, Anny-Odile Colson, Sean R. Klopfenstein, Thomas R. Downs, Kevin G. Peters, Matthew B. Maier, Jeffrey J. Neuman, Julie A. Farmer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1574-1578
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinolin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94deb8eb695847ffbb286bb5870663f2
https://doi.org/10.1016/j.bmcl.2005.12.051
https://doi.org/10.1016/j.bmcl.2005.12.051
Publikováno v:
Tetrahedron Letters. 47:3629-3631
A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acid esters and amidoximes in the presence of potassium carbonate was employed to synthesize a variety of mono-, bis- and tris-oxadiazoles in moderate to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc73afdb324dbc2f10c6878e6e4b14df
https://doi.org/10.1016/j.tetlet.2006.03.155
https://doi.org/10.1016/j.tetlet.2006.03.155
Autor:
Kande K D, Amarasinghe, Artem G, Evdokimov, Artem G, Evidokimov, Kevin, Xu, Cynthia M, Clark, Matthew B, Maier, Anil, Srivastava, Anny-Odile, Colson, Gina S, Gerwe, George E, Stake, Brian W, Howard, Matthew E, Pokross, Jeffrey L, Gray, Kevin G, Peters
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(16)
The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3c05f79a1a4e620626ea01c44e4375
https://pubmed.ncbi.nlm.nih.gov/16759857
https://pubmed.ncbi.nlm.nih.gov/16759857
Autor:
Matthew Pokross, Michael G. Davis, Frank Genbauffe, Artem G. Evdokimov, Matthew B. Maier, Kenneth D. Greis, Conrad Diven, Brian W. Howard, Elaine Eby-Wilkens, Vinit Rastogi, Shari Joy Soper, Kevin G. Peters
Publikováno v:
Journal of inorganic biochemistry. 96(2-3)
Organovanadium compounds have been shown to be insulin sensitizers in vitro and in vivo. One potential biochemical mechanism for insulin sensitization by these compounds is that they inhibit protein tyrosine phosphatases (PTPs) that negatively regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3268fce3bc01483fe4561d4b75567414
https://pubmed.ncbi.nlm.nih.gov/12888267
https://pubmed.ncbi.nlm.nih.gov/12888267
Autor:
Anny-Odile Colson, Matthew B. Maier, Kande Amarasinghe, Anil K Srivastava, Kevin Xu, George E. Stake, Brian W. Howard, Cynthia Monesa Clark, Kevin G. Peters, Matthew Pokross, Artem G. Evdokimov, Gina S. Gerwe, Jeffrey Lyle Gray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4745
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90ea7c7aef51589e21c0b3e6a3308b2
https://doi.org/10.1016/j.bmcl.2006.08.077
https://doi.org/10.1016/j.bmcl.2006.08.077