Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Matthew B. Greenblatt"'
Autor:
Zan Li, Baohong Shi, Na Li, Jun Sun, Xiangchen Zeng, Rui Huang, Seoyeon Bok, Xiaohui Chen, Jie Han, Alisha R. Yallowitz, Shawon Debnath, Michelle Cung, Zheng Ling, Chuan-Qi Zhong, Yixang Hong, Gang Li, Mascha Koenen, Paul Cohen, Xinhui Su, Hongbin Lu, Matthew B. Greenblatt, Ren Xu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The skeleton has been suggested to function as an endocrine organ controlling whole organism energy balance, however the mediators of this effect and their molecular links remain unclear. Here, utilizing Schnurri-3−/− (Shn3 −/− ) mic
Externí odkaz:
https://doaj.org/article/8c68d2e78dce4260ac94049ddf92d216
Autor:
Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular
Externí odkaz:
https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f
Autor:
Yu Chen, Long Zhang, Xueqing Shi, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew B. Greenblatt, Rongqin Ke, Jianming Huang, Zhe‐Sheng Chen, Ren Xu
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Loss of refreshment in nucleus pulposus (NP) cellularity leads to intervertebral disc (IVD) degeneration. Nevertheless, the cellular sequence of NP cell differentiation remains unclear, although an increasing body of literature has identifie
Externí odkaz:
https://doaj.org/article/9c873aa8f75840069f9fad1ac300e670
Autor:
Ohnmar Myint, Nithidol Sakunrangsit, Jatuphol Pholtaisong, Parichart Toejing, Pinyada Pho-on, Asada Leelahavanichkul, Somyoth Sridurongrit, Chatchawit Aporntewan, Matthew B. Greenblatt, Sutada Lotinun
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5829 (2024)
Transforming growth factor beta (TGF-β) is ubiquitously found in bone and plays a key role in bone turnover. Mice expressing constitutively active TGF-β receptor type I (Mx1;TβRICA mice) are osteopenic. Here, we identified the candidate genes invo
Externí odkaz:
https://doaj.org/article/a0c19c10c56641ecb43bc77ecadd1b5f
Autor:
Chujiao Lin, Qiyuan Yang, Dongsheng Guo, Jun Xie, Yeon-Suk Yang, Sachin Chaugule, Ngoc DeSouza, Won-Taek Oh, Rui Li, Zhihao Chen, Aijaz A. John, Qiang Qiu, Lihua Julie Zhu, Matthew B. Greenblatt, Sankar Ghosh, Shaoguang Li, Guangping Gao, Cole Haynes, Charles P. Emerson, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Skeletal progenitors provide a reservoir for bone-forming osteoblasts. However, the major energy source for their osteogenesis remains unresolved. Here, the authors demonstrate that ESCIT-mediated regulation of mitochondrial metabolism is required fo
Externí odkaz:
https://doaj.org/article/7ba9a8c0d31344639b3d19b6b3e7140e
Autor:
Yuhan Xia, Kazuki Inoue, Yong Du, Stacey J. Baker, E. Premkumar Reddy, Matthew B. Greenblatt, Baohong Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Mechanisms for inflammatory osteolysis are unclear. Here, Xia et al. find that TGFβ shifts the inflammatory action of TNF on macrophages to a potent osteoclastogenic function and identify a novel TGFβ/TNF-mediated non-canonical osteoclastogenic pro
Externí odkaz:
https://doaj.org/article/3f2eee2457094637bf28436cec7b90d8
Autor:
Sirikanda Jantaboon, Nithidol Sakunrangsit, Parichart Toejing, Asada Leelahavanichkul, Prapaporn Pisitkun, Matthew B. Greenblatt, Sutada Lotinun
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16944 (2023)
Chronic inflammation contributes to the development of skeletal disorders in patients with systemic lupus erythematosus (SLE). Activation of the host immune response stimulates osteoclast activity, which in turn leads to bone loss. Regenerating bone
Externí odkaz:
https://doaj.org/article/1033f12178f64546ae528f2198e108be
Autor:
Sheela R. Damle, Agata K. Krzyzanowska, Maximilian K. Korsun, Kyle W. Morse, Susannah Gilbert, Han Jo Kim, Oheneba Boachie-Adjei, Bernard A. Rawlins, Marjolein C. H. van der Meulen, Matthew B. Greenblatt, Chisa Hidaka, Matthew E. Cunningham
Publikováno v:
Cells, Vol 12, Iss 20, p 2488 (2023)
Bone morphogenetic protein (BMP) gene delivery to Lewis rat lumbar intervertebral discs (IVDs) drives bone formation anterior and external to the IVD, suggesting the IVD is inhospitable to osteogenesis. This study was designed to determine if IVD des
Externí odkaz:
https://doaj.org/article/d070ea3a8d62465ea1611f79d34193e0
Autor:
Kevin Staats, Branden R. Sosa, Emile-Victor Kuyl, Yingzhen Niu, Vincentius Suhardi, Kathleen Turajane, Reinhard Windhager, Matthew B. Greenblatt, Lionel Ivashkiv, Mathias P. G. Bostrom, Xu Yang
Publikováno v:
Bone & Joint Research, Vol 11, Iss 5, Pp 260-269 (2022)
Aims: To develop an early implant instability murine model and explore the use of intermittent parathyroid hormone (iPTH) treatment for initially unstable implants. Methods: 3D-printed titanium implants were inserted into an oversized drill-hole in t
Externí odkaz:
https://doaj.org/article/3da1a0e9f7074e13bbd4ca1cbabc29c5
Autor:
Juan L. Rodriguez-Flores, Radja Messai-Badji, Amal Robay, Ramzi Temanni, Najeeb Syed, Monika Markovic, Eiman Al-khayat, Fatima Qafoud, Zafar Nawaz, Ramin Badii, Yasser Al-Sarraj, Hamdi Mbarek, Wadha Al-Muftah, Muhammad Alvi, Mahboubeh R. Rostami, Juan Carlos Martinez Cruzado, Jason G. Mezey, Alya Al Shakaki, Joel A. Malek, Matthew B. Greenblatt, Khalid A. Fakhro, Khaled Machaca, Ajayeb Al-Nabet, Nahla Afifi, Andrew Brooks, Said I. Ismail, Asmaa Althani, Ronald G. Crystal
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-21 (2022)
Abstract Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop “QChip1,” an inexpensive genotyping microar
Externí odkaz:
https://doaj.org/article/37726560b48d41ea9a863392829c265f