Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew B. Dufek"'
Autor:
David Carter, Akshanth R. Polepally, Juki Ng, Ahmed Salem, Mohamad Shebley, Matthew B. Dufek, Apurvasena Parikh, Nael M. Mostafa, Kent Kamradt
Publikováno v:
Journal of Clinical Pharmacology
Elagolix is an oral gonadotropin‐releasing hormone receptor antagonist indicated for the management of endometriosis‐associated pain and in combination with estradiol/norethindrone acetate indicated for the management of heavy menstrual bleeding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622863b364cfd49f6d03128b0e958c96
https://doi.org/10.1002/jcph.1689
https://doi.org/10.1002/jcph.1689
Autor:
Charlotte D. Owens, Nelson B. Watts, Ahmed M. Soliman, Matthew B. Dufek, Michael P. Diamond, Ayman Al-Hendy, W. Rachel Duan, David F. Archer, Jingjing Gao, Linda D. Bradley, Bruce R. Carr, Elizabeth A. Stewart, James A. Simon, Kristof Chwalisz
Publikováno v:
Obstet Gynecol
To evaluate elagolix, an oral gonadotropin-releasing hormone receptor antagonist, alone or with add-back therapy, in premenopausal women with heavy menstrual bleeding (greater than 80 mL per month) associated with uterine leiomyomas.This double-blind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4ce471aba925c74f326004566e2e0d
https://doi.org/10.1097/aog.0000000000002933
https://doi.org/10.1097/aog.0000000000002933
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:660-666
Vaccination against nicotine blocks or attenuates nicotine-related behaviors relevant to addiction in rats. Passive immunization with nicotine-specific antibodies is an alternative to vaccination with the potential advantages of allowing control of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d991f7bab6bd3cf13999ff75023f2aad
https://doi.org/10.1124/jpet.105.097873
https://doi.org/10.1124/jpet.105.097873
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(9)
Recent studies showed that P-glycoprotein (P-gp) increases the portal bioavailability (FG) of loperamide by sparing its intestinal first-pass metabolism. Loperamide is a drug whose oral absorption is strongly attenuated by intestinal P-gp-mediated ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2147d01ad04dcd66c0f6414457c62bd0
https://pubmed.ncbi.nlm.nih.gov/23821186
https://pubmed.ncbi.nlm.nih.gov/23821186
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(3)
P-glycoprotein (P-gp) and CYP3A (cytochrome P450 3A, generally; Cyp3a, rodent enzyme) in the intestine can attenuate absorption of orally administered drugs. While some suggest that P-gp enhances intestinal metabolism by CYP3A/Cyp3a during absorption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba8b48cad652111913cb14e7528f7b2
https://pubmed.ncbi.nlm.nih.gov/23288866
https://pubmed.ncbi.nlm.nih.gov/23288866
Autor:
Matthew B. Dufek, Jin Yan Jin, Bei Wang, Mark J. Dresser, Jean A. Ayache, Richard A. Graham, Kenn L. Zerivitz, Jennifer A. Low, Ilsung Chang, Farkad Ezzet
Publikováno v:
Journal of cardiovascular pharmacology. 61(1)
Vismodegib was assessed as being of low risk for QT interval prolongation based on prior nonclinical and clinical experience. A dedicated study was conducted to further assess the potential for vismodegib to prolong the QTc interval.Given the nonline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f65b8535b1440a75ec4d435f4c253c3
https://pubmed.ncbi.nlm.nih.gov/23107871
https://pubmed.ncbi.nlm.nih.gov/23107871
Maternal tobacco use is associated with adverse developmental outcomes in offspring, including hyperactivity. Animal studies attempting to model this phenomenon have primarily used continuous s.c. nicotine infusion as the method of nicotine administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc10800b54825efc0e15e02810bef07
https://europepmc.org/articles/PMC1820587/
https://europepmc.org/articles/PMC1820587/
Autor:
Matthew B. Dufek, Frances M. Leslie, Mark G. LeSage, Paul R. Pentel, Y. Chen, Daniel E. Keyler, Chap T. Le
Publikováno v:
Neurotoxicology and teratology. 28(5)
Gestational exposure of rats to nicotine produces long-lasting alterations in brain development. Vaccination of adult female rats against nicotine reduces the distribution of maternally administered nicotine to fetal brain, suggesting that vaccinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c577e40de03be2018fd1c41dea08f3c6
https://pubmed.ncbi.nlm.nih.gov/16996246
https://pubmed.ncbi.nlm.nih.gov/16996246
Autor:
D E Raphael, Catherine A. Ross, Matthew B. Dufek, Daniel E. Keyler, Chap T. Le, Paul R. Pentel, Thomas J. Bramwell, Andrew D. Calvin, Mark G. LeSage
Publikováno v:
Biochemical pharmacology. 69(9)
Nicotine is a teratogen in rats and possibly in humans. Vaccination against nicotine is being studied as a possible treatment for nicotine dependence. The safety of maternal vaccination against nicotine during or prior to pregnancy is not known. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdb395c4cd67c022a4dc220ff83ad22
https://pubmed.ncbi.nlm.nih.gov/15826609
https://pubmed.ncbi.nlm.nih.gov/15826609
Publikováno v:
Pharmacology, biochemistry, and behavior. 79(3)
The objective of the present study was to determine the relative efficacy of nicotine priming and nicotine-paired stimuli in reinstating extinguished NSA in rats. The relative efficacy of different stimulus conditions in reinstating NSA was also dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75828680644218372a44922ae4354c72
https://pubmed.ncbi.nlm.nih.gov/15582022
https://pubmed.ncbi.nlm.nih.gov/15582022