Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Matthew B. Cascio"'
Autor:
Akira Sawa, Eiichiro Nagata, Siobhan Sutcliffe, Pratima Dulloor, Matthew B. Cascio, Yuji Ozeki, Sophie Roy, Christopher A. Ross, Solomon H. Snyder
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 267-274 (2005)
Accumulation of mutant Huntingtin (Htt), especially the N-terminal-cleaved Htt, participates in the pathophysiology of Huntington's disease (HD). It is difficult to elucidate temporal properties of the translocation of “endogenous” Htt using auto
Externí odkaz:
https://doaj.org/article/d2ce6638343e470f989bfe567c471d34
Autor:
Nilkantha, Sen, Makoto R, Hara, Abdullah Shafique, Ahmad, Matthew B, Cascio, Atsushi, Kamiya, Jeffrey T, Ehmsen, Nishant, Agrawal, Nishant, Aggrawal, Lynda, Hester, Sylvain, Doré, Solomon H, Snyder, Akira, Sawa
Publikováno v:
Neuron. 63(1):81-91
SummaryWe recently reported a cell death cascade whereby cellular stressors activate nitric oxide formation leading to S-nitrosylation of GAPDH that binds to Siah and translocates to the nucleus. The nuclear GAPDH/Siah complex augments p300/CBP-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca60c25a05a1cf0386c36d44236638f2
Autor:
Hiroyuki Koizumi, Matthew B. Cascio, Jennifer Chang, Yasukazu Takanezawa, Atsushi Kamiya, Manabu Takaki, Masahiko Morita, Toshifumi Tomoda, Caixin Zhan, Faith Dickerson, Akira Sawa, Robert H. Yolken, Sarah Elashvili, Hiroyuki Arai
Publikováno v:
Human Molecular Genetics. 15:3313-3323
Disrupted-In-Schizophrenia-1 (DISC1) is a unique susceptibility gene for major mental conditions, because of the segregation of its genetic variant with hereditary psychosis in a Scottish pedigree. Genetic association studies reproducibly suggest inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6647d915d415473ec52d94aa88bda47
https://doi.org/10.1093/hmg/ddl407
https://doi.org/10.1093/hmg/ddl407
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762:502-509
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classic glycolytic enzyme, and accumulating evidence has suggested that GAPDH is a multi-functional protein. In particular, its role as a mediator for cell death has been highlighted. For the last
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958df6309d1aa2d1b452498f4f69b412
https://doi.org/10.1016/j.bbadis.2006.01.012
https://doi.org/10.1016/j.bbadis.2006.01.012
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Autor:
Nishant Agrawal, Lynda D. Hester, Yuji Ozeki, Sangwon F. Kim, Jaime H. Cheah, Makoto R. Hara, Stephanie Tankou, Akira Sawa, Matthew B. Cascio, Masahiro Fujimuro, Solomon H. Snyder, S. Diane Hayward, Christopher D. Ferris, Masaaki Takahashi
Publikováno v:
Nature Cell Biology. 7:665-674
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity, translocating to the nucleus during apoptosis. Here we report a signalling pathway in which nitric oxide (NO) generation that follows apoptotic stimulation elicits S-nitrosylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfa181b6fc44ec5be8f430cddf5d923
https://doi.org/10.1038/ncb1268
https://doi.org/10.1038/ncb1268
Publikováno v:
Inhalation Toxicology. 15:675-685
Characterization of lung injury is important if timely therapeutic intervention is to be used properly and successfully. In this study, lung injury was defined as the progressive formation of pulmonary edema. Our model gas was phosgene, a pulmonary e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c138c171e3ab78577dacefda3a47721e
https://doi.org/10.1080/08958370390197245
https://doi.org/10.1080/08958370390197245
Autor:
Matthew B. Cascio, Jeffry S. Forster, Jamie L. Martin, Steven M. Duniho, Laura B. Carpin, Ted S. Moran, Alfred M. Sciuto
Publikováno v:
Toxicologic Pathology. 30:339-349
Phosgene (CG) is a highly irritant gas widely used industrially as a chemical intermediate for the production of dyes, pesticides, and plastics, and can cause life-threatening pulmonary edema within 24 hours of exposure. This study was designed to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb498a5da7eefc43deb0c5a2a733dc6
https://doi.org/10.1080/01926230252929918
https://doi.org/10.1080/01926230252929918
Autor:
Makoto R. Hara, Michael D. Kornberg, Neelam Shahani, Bobby Thomas, Matthew B. Cascio, Nilkantha Sen, Valina L. Dawson, Byoung-Il Bae, Ted M. Dawson, Akira Sawa, Solomon H. Snyder
Publikováno v:
Nature cell biology. 10(7)
Besides its role in glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) initiates a cell death cascade. Diverse apoptotic stimuli activate inducible nitric oxide synthase (iNOS) or neuronal NOS (nNOS), with the generated nitric oxide (NO) S-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5021c8e150f1c223683160ace65d03
https://pubmed.ncbi.nlm.nih.gov/18552833
https://pubmed.ncbi.nlm.nih.gov/18552833
Autor:
Lynda D. Hester, Makoto R. Hara, Byoung-Il Bae, Valina L. Dawson, Ted M. Dawson, Solomon H. Snyder, Akira Sawa, Matthew B. Cascio, Bobby Thomas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(10)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) participates in a cell death cascade wherein a variety of stimuli activate nitric oxide (NO) synthases with NO nitrosylating GAPDH, conferring on it the ability to bind to Siah, an E3-ubiquitin-ligase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee27cf525b625082c7685d9f1b25b34e
https://pubmed.ncbi.nlm.nih.gov/16505364
https://pubmed.ncbi.nlm.nih.gov/16505364
Autor:
Xiao-Jiang Li, Akira Sawa, Matthew B. Cascio, Cheryl L. Wellington, Makoto R. Hara, Michael R. Hayden, Solomon H. Snyder, Christopher A. Ross, Byoung-Il Bae, Hyo Chol Ha
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(9)
The pathophysiology of Huntington’s disease reflects actions of mutant Huntingtin (Htt) (mHtt) protein with polyglutamine repeats, whose N-terminal fragment translocates to the nucleus to elicit neurotoxicity. We establish that the nuclear transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a70c5d2995f7e9e4f67200b18f0fe26
https://pubmed.ncbi.nlm.nih.gov/16492755
https://pubmed.ncbi.nlm.nih.gov/16492755