Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases

Autor: Adam S. Olia, Cheng Cheng, Tongqing Zhou, Andrea Biju, Darcy R. Harris, Anita Changela, Hongying Duan, Vera B. Ivleva, Wing-Pui Kong, Li Ou, Reda Rawi, Yaroslav Tsybovsky, David J. Van Wazer, Angela R. Corrigan, Christopher A. Gonelli, Myungjin Lee, Krisha McKee, Sandeep Narpala, Sijy O’Dell, Danealle K. Parchment, Erik-Stephane D. Stancofski, Tyler Stephens, Ivy Tan, I-Ting Teng, Shuishu Wang, Qing Wei, Yongping Yang, Zhengrong Yang, Baoshan Zhang, Jan Novak, Matthew B. Renfrow, Nicole A. Doria-Rose, Richard A. Koup, Adrian B. McDermott, Jason G. Gall, Q. Paula Lei, John R. Mascola, Peter D. Kwong

Publikováno v: iScience, Vol 26, Iss 8, Pp 107403- (2023)

Summary: Soluble HIV-1-envelope (Env) trimers elicit immune responses that target their solvent-exposed protein bases, the result of removing these trimers from their native membrane-bound context. To assess whether glycosylation could limit these ba

Externí odkaz: https://doaj.org/article/f61151545f45450b8eb0961391496066

Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

Autor: Shannon L. Murphy, John D. Mahan, Jonathan P. Troost, Tarak Srivastava, Amy J. Kogon, Yi Cai, T. Keefe Davis, Hilda Fernandez, Alessia Fornoni, Rasheed A. Gbadegesin, Emily Herreshoff, Pietro A. Canetta, Patrick H. Nachman, Bryce B. Reeve, David T. Selewski, Christine B. Sethna, Chia-shi Wang, Sharon M. Bartosh, Debbie S. Gipson, Katherine R. Tuttle, Ali Gharavi, Wooin Ahn, Gerald B. Appel, Rupali S. Avasare, Revekka Babayev, Ibrahim Batal, Andrew S. Bomback, Eric Brown, Eric S. Campenot, Pietro Canetta, Brenda Chan, Vivette D. D’Agati, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Krzysztof Kiryluk, Fangming Lin, Francesca Lugani, Maddalena Marasa, Glen Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Jai Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, Simone Sanna-Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Larry A. Greenbaum, William E. Smoyer, Amira Al-Uzri, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Michael C. Braun, Aftab Chishti, Donna Claes, Carl Cramer, Keefe Davis, Elif Erkan, Daniel Feig, Michael Freundlich, Melisha Hanna, Guillermo Hidalgo, Amrish Jain, Myda Khalid, Mahmoud Kallash, MD, Jerome C. Lane, John Mahan, Nisha Mathews, Carla Nester, Cynthia Pan, Hiren Patel, Adelaide Revell, Rajasree Sreedharan, Julia Steinke, Scott E. Wenderfer, Craig S. Wong, Ronald Falk, William Cook, Vimal Derebail, Agnes Fogo, Adil Gasim, Todd Gehr, Raymond Harris, Jason Kidd, Louis-Philippe Laurin, Will Pendergraft, Vincent Pichette, Thomas Brian Powell, Matthew B. Renfrow, Virginie Royal, Lawrence B. Holzman, Sharon Adler, Charles Alpers, Raed Bou Matar, Elizabeth Brown, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Crystal Gadegbeku, Patrick Gipson, Leah Hasely, Sangeeta Hingorani, Michelle A. Hladunewich, Jonathan Hogan, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Kevin V. Lemley, Laura Malaga- Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O'Shaughnessy, John F. O’Toole, Rulan Parekh, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, John R. Sedor, Jeffrey Schelling, John C. Sperati, Agnes Swiatecka-Urban, Howard Trachtman, Joseph Weisstuch, Olga Zhdanova, Brenda Gillespie, Matthias Kretzler, Bruce M. Robinson, Laura Mariani, Matthew Wladkowski, Lisa M. Guay-Woodford

Publikováno v: Kidney International Reports, Vol 5, Iss 10, Pp 1679-1689 (2020)

Introduction: Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL with changing disease status. Methods: Cu

Externí odkaz: https://doaj.org/article/22aaf2057cd54d10aa49074d880c6040

Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers

Autor: Venkatram R. Atigadda, Mahendra P. Kashyap, Zhengrong Yang, Debasish Chattopadhyay, Nathalia Melo, Rajesh Sinha, Olga V. Belyaeva, Chu-Fang Chou, Pi-Ling Chang, Natalia Y. Kedishvili, Clinton J. Grubbs, Matthew B. Renfrow, Donald D. Muccio, Craig A. Elmets, Mohammad Athar

Publikováno v: J Med Chem

Compound 1 is a potent rexinoid that is highly effective in cancer chemoprevention but elevates serum triglycerides. In an effort to separate the lipid toxicity from the anticancer activity of 1, we synthesized four new analogs of rexinoid 1, of whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b40461637cc0f417346b98efcc6e89d
https://doi.org/10.1021/acs.jmedchem.2c00735

Protein-based profiling of the human IgA1 clonal repertoire revealed shared clones of serum polymeric IgA1 and milk secretory IgA1

Autor: Jan Novak, Matthew B. Renfrow, R. Glenn King, Colin Reily, Todd J. Green

Publikováno v: Cellular & Molecular Immunology. 20:305-307

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0247d6d0d852dedc9d592450548fda4
https://doi.org/10.1038/s41423-022-00965-z

Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy.

Autor: William J Placzek, Hiroyuki Yanagawa, Yuko Makita, Matthew B Renfrow, Bruce A Julian, Dana V Rizk, Yusuke Suzuki, Jan Novak, Hitoshi Suzuki

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190967 (2018)

IgA nephropathy is an autoimmune disease characterized by IgA1-containing glomerular immune deposits. We previously proposed a multi-hit pathogenesis model in which patients with IgA nephropathy have elevated levels of circulatory IgA1 with some O-gl

Externí odkaz: https://doaj.org/article/329c2cc8b46e47aaba9ff7597079f36d